{"orpha":45452,"name":"Idiopathic neonatal atrial flutter","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Idiopathic neonatal atrial flutter (AFL) is a rare rhythm disorder, characterized by sustained tachycardia in newborns and infants with an atrial rate often at around 440 beats/minute (range 340-580). AFL may manifest as asymptomatic tachycardia, congestive heart failure or hydrops.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-45452/","orphanet_url":"https://www.orpha.net/en/disease/detail/45452","names":{"fr":{"name":"Flutter auriculaire idiopathique du nouveau-né","definition":"Le flutter auriculaire idiopathique (AFL) du nouveau-né est un trouble rare du rythme cardiaque, caractérisé par une tachycardie soutenue chez les nouveau-nés et les nourrissons, avec un rythme auriculaire souvent autour de 440 battements/min (entre 340-580). Il peut se manifester par une tachycardie asymptomatique, une insuffisance cardiaque congestive ou un hydrops."},"de":{"name":"Vorhofflattern, idiopathisches neonatales","definition":"Das Idiopathische Neugeborenen-Vorhofflimmern (AFL) ist eine seltene Rhythmusstörung und gekennzeichnet durch anhaltende Tachykardie bei Neugeborenen und Säuglingen. Die Vorhoffrequenz liegt oft bei 440 Schlägen/Minute (Bereich 340-580). Manifestationen des AFL sind asymptomatische Tachykardie, kongestive Herzinsuffizienz und Hydrops."},"es":{"name":"Flutter auricular neonatal idiopático","synonyms":["Aleteo atrial idiopático neonatal"],"definition":"El flutter auricular neonatal idiopático (AFL) es una alteración rara del ritmo cardiaco caracterizada por taquicardia constante en recién nacidos y lactantes, con una frecuencia auricular que suele ser de alrededor de 440 latidos/minuto (rango de 340-580). El AFL se puede manifestar como taquicardia asintomática, insuficiencia cardiaca congestiva o hidrops fetal."},"it":{"name":"Flutter atriale idiopatico neonatale","definition":"Il flutter atriale neonatale idiopatico (AFL) è un'aritmia rara caratterizzata da tachicardia costante nei neonati e lattanti, con una frequenza atriale spesso intorno ai 440 battiti/minuto (frequenza 340-580). Il AFL può manifestarsi sotto forma di tachicardia asintomatica, insufficienza cardiaca congestizia o idrope."},"nl":{"name":"Idiopathische neonatale atriumflutter","synonyms":["Idiopathisch neonataal boezemfladderen"],"definition":"Idiopathische neonatale boezemflutter (AFL) is een zeldzame hartritmestoornis, gekenmerkt door aanhoudende tachycardie bij pasgeborenen en zuigelingen met vaak een atriale frequentie rond de 440 slagen/minuut (range 340-580). AFL kan zich als asymptomatische tachycardie, congestief hartfalen of hydrops manifesteren."},"pt":{"name":"Flutter auricular neonatal idiopático"},"pl":{"name":"Idiopatyczne niemowlęce trzepotanie przedsionków"},"cs":{"name":"Idiopatický novorozenecký síňový flutter"},"uk":{"name":"Ідіопатичне тріпотіння передсердь у новонароджених","definition":"Idiopathic neonatal atrial flutter (AFL) is a rare rhythm disorder, characterized by sustained tachycardia in newborns and infants with an atrial rate often at around 440 beats/minute (range 340-580). AFL may manifest as asymptomatic tachycardia, congestive heart failure or hydrops."},"zh":{"name":"特发性新生儿房扑"},"tr":{"name":"Yenidoğanın idiyopatik atriyal flutter"}},"xrefs":[{"source":"ICD-10","code":"P29.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"BC81.20","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"208964573"},{"source":"MONDO","code":"0018684","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4275090","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97929,"name":"Rare cardiac disease"},"parents":[{"orpha":218439,"name":"Non-genetic cardiac rhythm disease","classifications":[146]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Infancy","Neonatal"],"prevalence":[{"type":"Prevalence at birth","qualification":"Value and class","class":"1-9 / 100 000","value":1.5,"area":"Europe","status":"Validated","source":"[EXPERT]_23551862[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-9 / 100 000","value":2.1,"area":"United Kingdom","status":"Validated","source":"23551862[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-01-14","source":"29706767 [PMID]_263874[PMID]_9616850[PMID]_30511544[PMID]_32366806[PMID]","terms":[{"hpo":"HP:0003115","label":"Abnormal EKG","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0005150","label":"Abnormal atrioventricular conduction","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004755","label":"Supraventricular tachycardia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025074","label":"Abnormal QRS complex","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005162","label":"Abnormal left ventricular function","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004763","label":"Paroxysmal supraventricular tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012664","label":"Reduced left ventricular ejection fraction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008872","label":"Feeding difficulties in infancy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025116","label":"Fetal distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001789","label":"Hydrops fetalis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001520","label":"Large for gestational age","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009800","label":"Maternal diabetes","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null}]}}