{"orpha":454,"name":"Acquired ichthyosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare epidermal disease characterized by rough, dry skin with prominent, plate-like scaling. It is non-hereditary and usually arises during adulthood in the context of a variety of diseases or conditions, like various types of cancer, autoimmune diseases, endocrine disorders, nutritional deficiencies, but also as a side effect of certain medications. Severity depends on the underlying disease or condition.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-454/","orphanet_url":"https://www.orpha.net/en/disease/detail/454","names":{"fr":{"name":"Ichtyose acquise","definition":"Maladie rare de l'épiderme caractérisée par une peau rêche et sèche, accompagnée d'une importante desquamation sous la forme de plaques. La maladie n'est pas héréditaire et se manifeste généralement à l'âge adulte chez des patients présentant divers autres troubles ou maladies, tels que certains types de cancers, maladies auto-immunes, troubles endocriniens ou carences nutritionnelles, mais elle peut également être un effet secondaire de certains médicaments. La sévérité dépend de la maladie ou du trouble sous-jacent."},"de":{"name":"Ichthyose, erworbene","definition":"Eine seltene Epidermiserkrankung, die durch raue, trockene Haut mit auffälliger, plattenförmiger Schuppung gekennzeichnet ist. Sie ist nicht erblich und tritt in der Regel im Erwachsenenalter im Zusammenhang mit einer Vielzahl von Krankheiten oder Zuständen auf, z. B. verschiedenen Krebsarten, Autoimmunerkrankungen, endokrinen Störungen, Ernährungsmängeln, aber auch als Nebenwirkung bestimmter Medikamente. Der Schweregrad hängt von der zugrunde liegenden Krankheit oder dem Zustand ab."},"es":{"name":"Ictiosis adquirida","definition":"Es una enfermedad epidérmica poco frecuente caracterizada por una piel áspera y seca con una notable descamación en forma de placas. Se trata de un trastorno adquirido y que por lo general debuta en la edad adulta en el contexto de diferentes enfermedades o afecciones, tales como distintos tipos de cáncer, enfermedades autoinmunes, trastornos endocrinos o déficits nutricionales, aunque también puede ocurrir como un efecto secundario de ciertos medicamentos. La gravedad depende de la enfermedad o del trastorno subyacente."},"it":{"name":"Ittiosi acquisita","definition":"Si tratta di una malattia rara dell'epidermide, caratterizzata da cute ruvida e secca con marcata desquamazione sotto forma di placche. La malattia non è ereditaria e di solito esordisce nell'età adulta nel quadro di altre malattie, come vari tipi di tumore, malattie autoimmuni ed endocrine e deficit nutrizionali, ma anche come effetto collaterale di alcuni farmaci. La gravità dipende dalla malattia sottostante."},"nl":{"name":"Verworven ichthyosis","definition":"Een zeldzame epidermale ziekte, gekarakteriseerd door ruwe, droge huid met aanzienlijke, plaatachtige afschilfering. Het is niet erfelijk en ontstaat meestal in de volwassenheid in de context van verschillende ziekten of gesteldheid, zoals verschillende types van kanker, auto-immuunziekten, endocriene aandoeningen, nutritionele deficiënties, maar ook als neveneffect van bepaalde geneesmiddelen. De ernst hangt af van d onderliggende ziekte of conditie."},"pt":{"name":"Ictiose adquirida"},"pl":{"name":"Rybia łuska nabyta"},"cs":{"name":"Získaná ichtyóza"},"uk":{"name":"Набутий іхтіоз","definition":"A rare epidermal disease characterized by rough, dry skin with prominent, plate-like scaling. It is non-hereditary and usually arises during adulthood in the context of a variety of diseases or conditions, like various types of cancer, autoimmune diseases, endocrine disorders, nutritional deficiencies, but also as a side effect of certain medications. Severity depends on the underlying disease or condition."},"zh":{"name":"获得性鱼鳞病"},"tr":{"name":"Edinsel iktiyoz"}},"xrefs":[{"source":"ICD-10","code":"L85.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"ED50.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1504032289"},{"source":"MONDO","code":"0018683","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C538175","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0263386","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10021199","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":79354,"name":"Ichthyosis","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0000958","label":"Dry skin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0008064","label":"Ichthyosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000962","label":"Hyperkeratosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100326","label":"Immunologic hypersensitivity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000982","label":"Palmoplantar keratoderma","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200034","label":"Papule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001581","label":"Recurrent skin infections","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002665","label":"Lymphoma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006775","label":"Multiple myeloma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100242","label":"Sarcoma","frequency":"Occasional (29-5%)","criteria":null}]}}