{"orpha":449280,"name":"Scedosporiosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare mycosis caused by <i>Scedosporium</i> species, characterized by disparate disease pictures including pneumonia, skin and soft tissue infection, mycetoma, and disseminated infection. Central nervous system infection has also been reported. Infections with this ubiquitous mold can occur in a range of contexts like solid organ transplantation, chemotherapy, chronic lung disease, but also in immunocompetent hosts and near drowning.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-449280/","orphanet_url":"https://www.orpha.net/en/disease/detail/449280","names":{"fr":{"name":"Scédosporiose","definition":"Mycose rare causée par des espèces de <i>Scedosporium</i> et caractérisée par des tableaux cliniques disparates incluant une pneumonie, une infection de la peau et des tissus mous, un mycétome et une infection disséminée. Une infection du système nerveux central a également été rapportée. Les infections par cette moisissure ubiquitaire peuvent survenir dans divers contextes tels que la transplantation d'organes solides, la chimiothérapie, les maladies pulmonaires chroniques, mais également chez des hôtes immunocompétents ayant vécu un épisode de presque noyade."},"de":{"name":"Scedosporiose","definition":"Eine seltene Mykose, die durch <i>Scedosporium</i>-Spezies verursacht wird und durch unterschiedliche Krankheitsbilder gekennzeichnet ist, darunter Lungenentzündung, Haut- und Weichteilinfektion, Myzetom und disseminierte Infektion. Auch über Infektionen des Zentralnervensystems wurde berichtet. Infektionen mit diesem ubiquitären Schimmelpilz können in verschiedenen Zusammenhängen auftreten, z. B. bei Transplantation fester Organe, Chemotherapie, chronischen Lungenerkrankungen, aber auch bei immunkompetenten Wirten und seltener nach Aspiration von kontaminiertem Wasser nach einem beinahe-Ertrinkungsunfall."},"es":{"name":"Escedosporiosis","definition":"Es una micosis poco frecuente causada por especies de <i>Scedosporium</i>, caracterizada por cuadros clínicos variables, incluyendo neumonía, infección cutánea y de los tejidos blandos, micetoma e infección diseminada. También se ha descrito infección del sistema nervioso central. Las infecciones con este moho ubicuo pueden ocurrir en contextos diversos tales como un trasplante de órganos sólidos, la quimioterapia, la enfermedad pulmonar crónica, aunque también en hospedadores inmunocompetentes y en individuos cercanos al ahogamiento."},"it":{"name":"Infezione da Scedosporium","definition":"Si tratta di una micosi rara causata dalla specie <i>Scedosporium</i>, caratterizzata da diversi quadri clinici, che comprendono la polmonite, l'infezione della cute e dei tessuti molli, il micetoma e le infezioni diffuse. Sono stati descritti casi di infezione del sistema nervoso centrale. Le infezioni causate da questa muffa ubiquitaria possono avvenire in diversi contesti, come il trapianto di organo solido, la chemioterapia e la pneumopatia cronica, ma anche negli ospiti immunocompetenti e nelle persone che hanno rischiato l'annegamento."},"nl":{"name":"Scedosporiose","definition":"Een zeldzame mycose, veroorzaakt door soorten van het geslacht <i>Scedosporium</i>, en gekarakteriseerd door verschillende ziektebeelden, waaronder pneumonie, infectie van huid en weke delen, mycetoom, en gedissemineerde infectie. Infectie van centraal zenuwstelsel werd ook reeds gerapporteerd. Infectie met deze alomtegenwoordige schimmel kan voorkomen in verschillende contexten, zoals transplantatie van solide orgaan, chemotherapie, chronische longziekte, maar ook bij immuuncompetente gastheren en bijna-verdrinking."},"pt":{"name":"Scedosporiose"},"pl":{"name":"Scedosporioza"},"cs":{"name":"Scedosporióza"},"uk":{"name":"Сцедоспоріоз","definition":"A rare mycosis caused by <i>Scedosporium</i> species, characterized by disparate disease pictures including pneumonia, skin and soft tissue infection, mycetoma, and disseminated infection. Central nervous system infection has also been reported. Infections with this ubiquitous mold can occur in a range of contexts like solid organ transplantation, chemotherapy, chronic lung disease, but also in immunocompetent hosts and near drowning."},"zh":{"name":"赛多银屑病","definition":"一种由小孢子虫引起的罕见真菌病，其特征在于不同的疾病表现，包括肺炎，皮肤和软组织感染，真菌瘤和弥散性感染在内的各种疾病。也有中枢神经系统感染的报道。这种无处不在的霉菌的感染可发生在多种情况下，例如实体器官移植，化学疗法，慢性肺部疾病，但也可发生在有正常免疫能力的宿主中，和溺水者中。"},"tr":{"name":"Skedosporioz"}},"xrefs":[{"source":"ICD-10","code":"B48.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1F2H","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"807637046"},{"source":"MONDO","code":"0018668","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C000656924","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1142170","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10059045","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163591,"name":"Rare mycosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Australia","status":"Validated","source":"19549223[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2014[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-31","source":"29567285[PMID]_26353885[PMID]_29044831[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032255","label":"Opportunistic fungal infection","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032169","label":"Severe infection","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010766","label":"Ectopic calcification","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032262","label":"Pulmonary tuberculosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001482","label":"Subcutaneous nodule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032162","label":"Unusual skin infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012210","label":"Abnormal renal morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002795","label":"Abnormal respiratory system physiology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001977","label":"Abnormal thrombosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005265","label":"Abnormality of the jejunum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032176","label":"Apical pulmonary opacity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005059","label":"Arthralgia/arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0410263","label":"Brain imaging abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031994","label":"Bronchial breath sound","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012387","label":"Bronchitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000819","label":"Diabetes mellitus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032159","label":"Fungal meningitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0020101","label":"Invasive fungal infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011919","label":"Pleural empyema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002102","label":"Pleuritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002206","label":"Pulmonary fibrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003095","label":"Septic arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000246","label":"Sinusitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Occasional (29-5%)","criteria":null}]}}