{"orpha":443084,"name":"Baroreflex failure","type":"Clinical syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare autonomic nervous system disorder characterized by diminished or absent buffering capability to prevent blood pressure from rising or falling excessively, due to abnormalities in the vascular baroreceptors, the glossopharyngeal or vagal nerves, or the brain stem. Typical clinical presentations are acute severe sustained hypertension, tachycardia, and headache, or volatile hypertension and tachycardia with headache, diaphoresis, flushing, and emotional instability. Rare cases rather present with hypotension, bradycardia, and dizziness or syncope.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-443084/","orphanet_url":"https://www.orpha.net/en/disease/detail/443084","names":{"fr":{"name":"Insuffisance du baroréflexe","definition":"Maladie rare du système nerveux autonome caractérisée par la diminution ou l'absence de la capacité de régulation permettant d'empêcher la pression artérielle d'augmenter ou de diminuer de manière excessive, causée par des anomalies au niveau des barorécepteurs vasculaires, des nerfs glossopharyngiens ou vagaux, ou du tronc cérébral. Les signes cliniques typiques sont une hypertension aiguë sévère et persistante, une tachycardie et des maux de tête, ou une hypertension très variable et une tachycardie avec des maux de tête, une diaphorèse, des bouffées vasomotrices et une instabilité émotionnelle. Dans des cas plus rares, les patients présentent plutôt une hypotension, une bradycardie et des vertiges ou une syncope."},"de":{"name":"Baroreflexversagen","definition":"Eine seltene Störung des autonomen Nervensystems, die durch ein vermindertes oder fehlendes Reaktionsvermögen zur Verhinderung eines übermäßigen Blutdruckanstiegs oder -abfalls gekennzeichnet ist und auf Anomalien der vaskulären Barorezeptoren, der Glossopharyngeus- oder Vagusnerven oder des Hirnstamms beruht. Typische klinische Symptome sind akuter schwerer anhaltender Bluthochdruck, Tachykardie und Kopfschmerzen oder flüchtiger Bluthochdruck und Tachykardie mit Kopfschmerzen, Diaphorese, Flush und emotionaler Instabilität. In seltenen Fällen treten Hypotonie, Bradykardie und Schwindel oder Synkopen auf."},"es":{"name":"Insuficiencia del reflejo barorreceptor","definition":"Es un trastorno poco frecuente del sistema nervioso autónomo caracterizado por una disminución o ausencia de la capacidad amortiguadora que evita que la presión arterial aumente o disminuya excesivamente, debido a anomalías en los barorreceptores vasculares, en el nervio glosofaríngeo o el vago o en el tronco encefálico. Las presentaciones clínicas típicas son hipertensión sostenida grave aguda, taquicardia y cefalea, o bien hipertensión volátil y taquicardia con cefalea, diaforesis, rubor y labilidad emocional. Los casos más raros o infrecuentes se presentan con hipotensión, bradicardia y mareos o síncope."},"it":{"name":"Insufficienza del baroriflesso","definition":"Si tratta di una malattia rara del sistema nervoso autonomo, caratterizzata dalla riduzione o dall'incapacità di regolare l'eccessivo aumento o caduta della pressione arteriosa. È causata da alcune anomalie dei barorecettori vascolari, dei nervi glossofaringei o vagali o del tronco encefalico. Il quadro clinico comprende l'ipertensione grave acuta e persistente, la tachicardia e la cefalea, oppure l'ipertensione variabile e la tachicardia con cefalea, diaforesi, vampate e instabilità emotiva. In rari casi si associa a ipotensione, bradicardia, vertigini o sincope."},"nl":{"name":"Baroreflexfalen","definition":"Een zeldzame aandoening van autonoom zenuwstelsel, gekarakteriseerd door verminderde of afwezige buffercapaciteit om excessief stijgende of dalende bloeddruk te vermijden, als gevolg van afwijkingen van vasculaire baroreceptoren, nervus glossopharyngeus of nervus vagus, of hersenstam. Typische klinische presentaties zijn acute ernstige aanhoudende hypertensie, tachycardie, en hoofdpijn, of labiele hypertensie en tachycardie met hoofdpijn, diaforese, blozen, en emotionele instabiliteit. Zeldzame gevallen vertonen hypotensie, bradycardie, en duizeligheid of syncope."},"pt":{"name":"Falência do barorreflexo"},"pl":{"name":"Niewydolność baroreceptorów"},"cs":{"name":"Selhání baroreflexu"},"uk":{"name":"Порушення барорефлексу","definition":"A rare autonomic nervous system disorder characterized by diminished or absent buffering capability to prevent blood pressure from rising or falling excessively, due to abnormalities in the vascular baroreceptors, the glossopharyngeal or vagal nerves, or the brain stem. Typical clinical presentations are acute severe sustained hypertension, tachycardia, and headache, or volatile hypertension and tachycardia with headache, diaphoresis, flushing, and emotional instability. Rare cases rather present with hypotension, bradycardia, and dizziness or syncope."},"zh":{"name":"压力反射障碍","definition":"罕见的自主神经系统疾病，其特征是由于血管压力感受器、舌咽或迷走神经或脑干异常导致的血压调节功能减弱或异常。典型的临床表现为急性严重持续高血压，心动过速和头痛，或反复无常的高血压和心动过速并伴有头痛，发汗，潮红和情绪不稳定。罕见病例表现为低血压，心动过缓，头晕或晕厥。"},"tr":{"name":"Barorefleks hatası"}},"xrefs":[{"source":"ICD-10","code":"G90.4","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8D89.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"880662615"},{"source":"MONDO","code":"0018617","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1959798","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"10664","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":423662,"name":"Rare autonomic nervous system disorder","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}