{"orpha":440368,"name":"Necrotizing soft tissue infection","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["NSTI"],"definition":"A rare infectious disease characterized by painful, rapidly progressive infection of deep soft tissue structures. Infections can be mono- or polymicrobial and involve gram-positive cocci, enteric gram-negative bacilli, anaerobes, among others. Fungal infections have also been described in rare cases. Physical examination findings are often subtle and may include erythema, bullae, induration of subcutaneous tissues, and tenderness to palpation.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-440368/","orphanet_url":"https://www.orpha.net/en/disease/detail/440368","names":{"fr":{"name":"Infection nécrosante des tissus mous","synonyms":["NSTI"],"definition":"Maladie infectieuse rare caractérisée par une infection douloureuse et rapidement progressive des structures profondes des tissus mous. Les infections peuvent être mono- ou polymicrobiennes et impliquer, entre autres, des cocci à Gram positif, des bacilles entériques à Gram négatif et des bacilles anaérobies. Dans de rares cas, des infections fongiques ont également été rapportées. Les signes cliniques observés à l'examen physique sont souvent subtils et peuvent inclure un érythème, des bulles, une induration des tissus sous-cutanés et une sensibilité à la palpation."},"de":{"name":"Nekrotisierende Weichteilinfektion","synonyms":["NSTI"],"definition":"Eine seltene Infektionskrankheit, die durch eine schmerzhafte, rasch fortschreitende Infektion der tiefen Weichteilstrukturen gekennzeichnet ist. Die Infektionen können mono- oder polymikrobiell sein und u. a. grampositive Kokken, enterische gramnegative Bazillen und Anaerobier umfassen. In seltenen Fällen sind auch Pilzinfektionen beschrieben worden. Die Befunde der körperlichen Untersuchung sind oft unauffällig und können Rötungen, Bläschen, Verhärtungen des subkutanen Gewebes und Schmerzempfindlichkeit beim Abtasten umfassen."},"es":{"name":"Infección necrosante de partes blandas","synonyms":["NSTI"],"definition":"Es una enfermedad infecciosa poco frecuente caracterizada por una infección dolorosa y rápidamente progresiva de las estructuras de los tejidos blandos profundos. La infección puede ser mono- o polimicrobiana, incluyendo los cocos Gram positivos, los bacilos Gram negativos entéricos, y los anaerobios, entre otros. En casos poco frecuentes, también se han descrito infecciones fúngicas. Los hallazgos de la exploración física suelen ser sutiles, pudiendo incluir eritema, bullas, induración del tejido subcutáneo y dolorimiento a la palpación."},"it":{"name":"Infezione necrotizzante dei tessuti molli","definition":"Si tratta di una malattia infettiva rara, caratterizzata da un'infezione dolorosa a progressione rapida dei tessuti molli profondi. Le infezioni possono essere mono- o polimicrobiche e sono causate da cocchi gram-positivi, bacilli enterici gram-negativi, anaerobi e da altri patogeni. Sono stati descritti rari casi di infezioni fungine. I sintomi osservati all'esame obiettivo possono essere sfumati, e comprendono l'eritema, le bolle, l'indurimento dei tessuti sottocutanei e la sensibilità alla palpazione."},"nl":{"name":"Necrotiserende infectie van weke delen","synonyms":["NSTI"],"definition":"Een zeldzame infectieziekte, gekarakteriseerd door pijnlijke, snel progressieve infectie van diepe weke delen. Infectie kan mono- of polymicrobieel zijn, en met betrokkenheid van onder meer grampositieve kokken, enterische gramnegatieve bacillen, en/of anaeroben. In zeldzame gevallen werden ook schimmelinfecties beschreven. Bevindingen van lichamelijk onderzoek zijn vaak subtiel en omvatten onder meer erytheem, blaren, induratie van onderhuids weefsel, en gevoeligheid voor palpatie."},"pt":{"name":"Infecção necrotizante dos tecidos moles","synonyms":["NSTI"]},"pl":{"name":"Martwicze zakażenie tkanek miękkich","synonyms":["NSTI"]},"cs":{"name":"Nekrotizující infekce měkkých tkání","synonyms":["NSTI"]},"uk":{"name":"Некротична інфекція мяких тканин","synonyms":["NSTI"],"definition":"A rare infectious disease characterized by painful, rapidly progressive infection of deep soft tissue structures. Infections can be mono- or polymicrobial and involve gram-positive cocci, enteric gram-negative bacilli, anaerobes, among others. Fungal infections have also been described in rare cases. Physical examination findings are often subtle and may include erythema, bullae, induration of subcutaneous tissues, and tenderness to palpation."},"zh":{"name":"坏死性软组织感染","synonyms":["NSTI"],"definition":"一种罕见的传染病，其特征在于疼痛的迅速进展的深部软组织感染，迅速进行性感染。感染可以是单种微生物或多种微生物，包括革兰氏阳性球菌，肠道革兰氏阴性杆菌，厌氧菌等。在极少数情况下还可包括真菌感染。体格检查结果表型较轻，可能包括红斑，大疱，皮下组织硬结和触诊压痛。"},"tr":{"name":"Nekrotizan yumuşak doku enfeksiyonu","synonyms":["NSTI"]}},"xrefs":[{"source":"ICD-10","code":"M72.6","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1B71","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"MONDO","code":"0018602","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2732890","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10076637","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[{"orpha":699678,"name":"Necrotizing cellulitis","type":"Clinical subtype"},{"orpha":699697,"name":"Necrotizing fasciitis","type":"Clinical subtype"},{"orpha":699702,"name":"Necrotizing myositis","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[],"phenotypes":null}