{"orpha":438279,"name":"Human infection by orthopoxvirus","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare viral disease characterized by fever, malaise, lymphadenopathy, and a maculopapular exanthema spreading from the site of infection to other regions of the body. The skin lesions eventually dry out and may leave behind scars. The most relevant orthopox species for human disease after the eradication of the variola virus, which was responsible for smallpox, are the monkeypox virus and the cowpox virus. Infections with these viruses typically take a benign course.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-438279/","orphanet_url":"https://www.orpha.net/en/disease/detail/438279","names":{"fr":{"name":"Infection humaine à l'orthopoxvirus","definition":"Maladie virale rare caractérisée par de la fièvre, des malaises, une lymphadénopathie et un exanthème maculo-papuleux se propageant du site de l'infection à d'autres régions du corps. Les lésions cutanées finissent par se dessécher et peuvent laisser des cicatrices. Après l'éradication du virus de la variole, responsable de la variole chez l'homme, les espèces d'orthopoxvirus les plus virulentes pour l'homme sont le virus de la variole du singe et le virus de la variole de la vache. L'évolution de ce type d'infections est généralement bénigne."},"de":{"name":"Humane Orthopockenviren-Infektion","definition":"Eine seltene Viruserkrankung, die durch Fieber, Unwohlsein, Lymphadenopathie und ein makulopapulöses Exanthem gekennzeichnet ist, das sich vom Infektionsherd auf andere Körperregionen ausbreitet. Die Hautläsionen trocknen schließlich aus und können Narben hinterlassen. Nach der Ausrottung des für die Pocken verantwortlichen Variola-Virus sind das Affenpocken-Virus und das Kuhpocken-Virus die wichtigsten Orthopox-Viren für den Menschen. Infektionen mit diesen Viren nehmen in der Regel einen gutartigen Verlauf."},"es":{"name":"Infección humana por orthopoxvirus","definition":"Es una enfermedad viral poco frecuente caracterizada por fiebre, malestar, linfadenopatía y por un exantema maculopapular que se expande desde el sitio de la infección hasta otras regiones del cuerpo. Posteriormente, las lesiones cutáneas se secan, pudiendo provocar cicatrices. Las especies ortopoxvirus más relevantes para la enfermedad humana, después de la erradicación del virus responsable de la viruela, son el virus de la viruela del mono y el virus de la viruela bovina. Por lo general, las infecciones por estos virus siguen un curso benigno."},"it":{"name":"Infezione umana da orthopoxvirus","definition":"Si tratta di una malattia virale rara, caratterizzata da febbre, malessere, linfoadenopatia e da un esantema maculo-papulare che dal sito dell'infezione si estende verso altre zone del corpo. Una volta seccate, le lesioni cutanee possono lasciare cicatrici. Le specie di orthopox più rilevanti per la malattia umana dopo l'eradicazione del variola virus, responsabile del vaiolo umano, sono il virus del vaiolo delle scimmie e il virus del vaiolo bovino. Le infezioni causate da questi virus in genere hanno un decorso benigno."},"nl":{"name":"Humane infectie door orthopoxvirus","definition":"Een zeldzame virale ziekte, gekarakteriseerd door koorts, malaise, lymfadenopathie, en maculopapulair exantheem dat zich verspreidt vanaf de plaats van infectie naar andere delen van het lichaam. De huidlaesies drogen na verloop van tijd uit en kunnen littekens nalaten. De meest relevante Orthopoxvirussen voor humane ziekte sinds uitroeiing van variolavirus, dat verantwoordelijk was voor pokken, zijn apenpokkenvirus en koepokkenvirus. Infectie met deze virussen vertonen doorgaans een goedaardig verloop."},"pt":{"name":"Infecção humana por ortopoxvírus"},"pl":{"name":"Zakażenie ludzkim ortopokswirusem"},"cs":{"name":"Humánní infekce orthopoxviry"},"uk":{"name":"Інфікування людини ортопоксвірусом","definition":"A rare viral disease characterized by fever, malaise, lymphadenopathy, and a maculopapular exanthema spreading from the site of infection to other regions of the body. The skin lesions eventually dry out and may leave behind scars. The most relevant orthopox species for human disease after the eradication of the variola virus, which was responsible for smallpox, are the monkeypox virus and the cowpox virus. Infections with these viruses typically take a benign course."},"zh":{"name":"正痘病毒感染","definition":"一种罕见的病毒性疾病，其特征是发烧，全身发力，淋巴结肿大和斑丘疹样皮疹，从感染部位扩散到身体其他部位。皮肤病变最终变干，可能留下疤痕。根除天花的天花病毒之后，与人类疾病最相关的正痘物种是猴痘病毒和牛痘病毒。这些病毒导致的感染通常是良性的。"},"tr":{"name":"Ortopoksvirus kaynaklı insan enfeksiyonu"}},"xrefs":[{"source":"ICD-10","code":"B03","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"B04","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"B08.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1E70","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"2054716425"},{"source":"ICD-11","code":"1E71","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"160886685"},{"source":"ICD-11","code":"1E72","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1205745537"},{"source":"ICD-11","code":"1E73","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1275065853"},{"source":"ICD-11","code":"1E74","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"444002285"},{"source":"MONDO","code":"0018583","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1532229","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":391658,"name":"OBSOLETE: Cowpox infection","status":"inactive"},{"type":"Referred to","orpha":415675,"name":"OBSOLETE: Small pox","status":"inactive"}],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2010[OTHER]"}],"phenotypes":null}