{"orpha":435743,"name":"Congenital urachal anomaly","type":"Category","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":"Congenital urachal anomaly (CUA) describes a group of urachal remnants, found more frequently in males than females, that result from incomplete closure of the urachus (an embryological remnant of the allantois) during prenatal development, and that are usually asymptomatic (and found as an incidental finding on a radiological study) but can also present with umbilical discharge (in patent urachus or urachal sinus), infraumblical mass and pain, or with complications such as obstruction and infection. CUAs include patent urachus, urachal sinus, urachal cyst and urachal diverticulum.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-435743/","orphanet_url":"https://www.orpha.net/en/disease/detail/435743","names":{"fr":{"name":"Anomalie congénitale de l'ouraque","definition":"Groupe de vestiges de l'ouraque, plus fréquents chez l'homme que chez la femme, qui résultent d'une fermeture incomplète de l'ouraque (un vestige embryologique du canal allantoïdien) au cours du développement prénatal. Généralement asymptomatiques (et découverts fortuitement lors d'un examen radiologique), un écoulement ombilical (en cas de fistule de l'ouraque ou de sinus de l'ouraque), une masse et une douleur sous-ombilicales, ou des complications telles qu'obstruction et infection peuvent tout de même être observés. Fistule de l'ouraque, sinus de l'ouraque, kyste de l'ouraque et diverticule de l'ouraque sont autant d'anomalies congénitales de l'ouraque."},"de":{"name":"Urachus-Anomalie, kongenitale"},"es":{"name":"Anomalía congénita uracal","definition":"Describe un grupo de restos uracales remanentes , que se encuentran con mayor frecuencia en varones que en mujeres, causados por el cierre incompleto del uraco (un remanente embrionario del alantoides) durante el desarrollo prenatal y que, por lo general, son asintomáticos (descubriéndose como un hallazgo incidental en estudios radiológicos). T también se pueden presentar como drenaje umbilical (en el uraco persistente o el seno uracal), masa infraumbilical y dolor, o complicaciones tales como obstrucción e infección. Estas anomalías incluyen el uraco persistente, el seno uracal, el quiste uracal y el divertículo uracal."},"it":{"name":"Anomalia congenita dell'uraco","definition":"L'anomalia congenita dell'uraco (CUA) comprende un gruppo di residui dell'uraco, che vengono riscontrati più spesso nei maschi e sono secondari alla chiusura incompleta dell'uraco (residuo embrionale dell'allantoide) durante lo sviluppo prenatale. Di solito è asintomatica (viene diagnosticata casualmente in occasione di esami radiologici), ma può anche manifestarsi con perdite dall'ombelico (in presenza di uraco pervio o seno uracale), o con una massa infraombelicale e dolore, oppure con complicanze come l'occlusione e le infezioni. Le CUA comprendono l'uraco pervio, il seno uracale, la cisti dell'uraco e il diverticolo dell'uraco (si vedano questi termini)."},"nl":{"name":"Congenitale urachale anomalie","synonyms":["Congenitale anomalie van urachus"],"definition":"Congenitale urachale anomalie (CUA) beschrijft een groep van urachale resten die frequenter aangetroffen worden bij mannen dan bij vrouwen en die het gevolg zijn van onvolledige sluiting van de urachus (een embryologisch overblijfsel van de allantoïs) tijdens de prenatale ontwikkeling. Ze zijn meestal asymptomatisch (en een toevallige bevinding bij radiologisch onderzoek) maar kunnen ook voorkomen met afscheiding uit de navel (bij persisterende urachus of urachale sinus), infra-umbilicale massa en pijn, of met complicaties zoals obstructie en infectie. CUA's omvatten persisterende urachus, urachale sinus, urachale cyste en urachaal divertikel (zie deze termen)."},"pt":{"name":"Anomalia congénita uracal"},"pl":{"name":"Wrodzona wada moczownika"},"cs":{"name":"Vrozené anomálie urachu"},"uk":{"name":"Вроджена аномалія сечоводу","definition":"Congenital urachal anomaly (CUA) describes a group of urachal remnants, found more frequently in males than females, that result from incomplete closure of the urachus (an embryological remnant of the allantois) during prenatal development, and that are usually asymptomatic (and found as an incidental finding on a radiological study) but can also present with umbilical discharge (in patent urachus or urachal sinus), infraumblical mass and pain, or with complications such as obstruction and infection. CUAs include patent urachus, urachal sinus, urachal cyst and urachal diverticulum (see these terms)."},"zh":{"name":"先天性脐尿管异常","definition":"先天性尿道异常（CUA）是脐尿管残留导致的一组疾病，其在男性中的发生频率高于女性，该病是由于产前发育过程中的脐尿管（胚胎发育过程中尿囊的残余结构）未完全闭合而导致的，通常无症状（可能在放射学检查中偶然发现），但也可能出现脐带分泌物（在未闭的脐尿管或脐尿管窦道），脐下肿块和疼痛，或伴有阻塞和感染等并发症。 CUA包括脐尿管未闭，脐尿管窦，脐尿管囊肿和脐尿管憩室（参见这些术语）。"},"tr":{"name":"Doğumsal urakal anomali"}},"xrefs":[{"source":"MONDO","code":"0018565","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18565","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1739100","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":93546,"name":"Non-syndromic renal or urinary tract malformation","classifications":[147,188,233]},{"orpha":182124,"name":"Non-syndromic urogenital tract malformation of male and female","classifications":[147,185,233]}],"children":[{"orpha":431341,"name":"Patent urachus","type":"Morphological anomaly"},{"orpha":488,"name":"Urachal cyst","type":"Morphological anomaly"},{"orpha":431347,"name":"Urachal diverticulum","type":"Morphological anomaly"},{"orpha":431344,"name":"Urachal sinus","type":"Morphological anomaly"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Antenatal","Neonatal"],"prevalence":[],"phenotypes":null}