{"orpha":431341,"name":"Patent urachus","type":"Morphological anomaly","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Patent urachus is a type of congenital urachal anomaly characterized by a persistent communication between the bladder and the umbilicus, secondary to non occlusion of the urachal lumen, manifesting as clear drainage from the umbilicus.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-431341/","orphanet_url":"https://www.orpha.net/en/disease/detail/431341","names":{"fr":{"name":"Fistule de l'ouraque","definition":"La fistule de l'ouraque est un type d'anomalie congénitale de l'ouraque , caractérisée par une communication persistante entre la vessie et l'ombilic, secondaire à la non-occlusion de la lumière de l'ouraque, se manifestant par le drainage par l'ombilic d'un fluide clair."},"de":{"name":"Offener Urachus","synonyms":["Offener Ductus Urachus"]},"es":{"name":"Uraco persistente","definition":"Es un tipo de anomalía uracal congénita caracterizada por la presencia de una comunicación persistente entre la vejiga y el ombligo debida a la ausencia de oclusión de la luz del uraco, que se manifiesta con un drenaje claro desde el ombligo."},"it":{"name":"Pervietà dell'uraco","definition":"La pervietà dell'uraco è un'anomalia congenita dell'uraco (si veda questo termine), caratterizzata dalla persistenza della comunicazione tra la vescica e l'ombelico, secondaria alla mancata chiusura del lume uracale, che si manifesta con la fuoriuscita di liquido chiaro dall'ombelico."},"nl":{"name":"Persisterende urachus","definition":"Persisterende urachus is een type van congenitale urachale anomalie (zie deze term) dat gekarakteriseerd wordt door een blijvende communicatie tussen de blaas en de navel, secundair aan de afwezigheid van occlusie van het urachale lumen, en dat zich manifesteert als afvoer van een heldere vloeistof uit de navel."},"pt":{"name":"Úraco permeável"},"pl":{"name":"Przetrwały moczownik"},"cs":{"name":"Urachus patens"},"uk":{"name":"Відкритий урахус","definition":"Patent urachus is a type of congenital urachal anomaly (see this term) characterized by a persistent communication between the bladder and the umbilicus, secondary to non occlusion of the urachal lumen, manifesting as clear drainage from the umbilicus."},"zh":{"name":"开放性脐尿管","definition":"开放性脐尿管是一种先天性尿道异常（见此术语），其特征是膀胱和脐带之间持续连通，继发于尿道腔未闭，表现为从脐带里流出清亮液体。"},"tr":{"name":"Patent urakus"}},"xrefs":[{"source":"ICD-10","code":"Q64.4","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"LB03.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1391202028"},{"source":"MONDO","code":"0018551","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0266357","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":435743,"name":"Congenital urachal anomaly","classifications":[147,185,188,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Neonatal"],"prevalence":[{"type":"Prevalence at birth","qualification":"Value and class","class":"1-9 / 100 000","value":1.75,"area":"United States","status":"Validated","source":"3404578[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-09-26","source":"32491655[PMID]_36363578[PMID]_33421441[PMID]","terms":[{"hpo":"HP:0010881","label":"Abnormality of the umbilical cord","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010479","label":"Patent urachus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100645","label":"Cystocele","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0034267","label":"Pelvic pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000010","label":"Recurrent urinary tract infections","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012618","label":"Urachal cyst","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010957","label":"Congenital posterior urethral valve","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032435","label":"Neonatal omphalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005420","label":"Recurrent gram-negative bacterial infections","frequency":"Occasional (29-5%)","criteria":null}]}}