{"orpha":43117,"name":"Acute tricyclic antidepressant poisoning","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, potentially lethal intoxication characterized by life-threatening arrhythmias (sinus tachycardias, premature ventricular contractions, ventricular arrhythmias), anticholinergic toxidrome (mydriasis, dry mucous membrane, tachycardia, hypertension), central nervous system toxicity (lethargy, coma, myoclonic jerks), refractory hypotension and sudden death.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-43117/","orphanet_url":"https://www.orpha.net/en/disease/detail/43117","names":{"fr":{"name":"Intoxication aiguë par les antidépresseurs tricycliques","definition":"Intoxication rare, potentiellement létale, caractérisée par des arythmies engageant le pronostic vital (tachycardies sinusales, contractions ventriculaires prématurées, arythmies ventriculaires), un syndrome anticholinergique (mydriase, sécheresse des muqueuses, tachycardie, hypertension), une neurotoxicité (léthargie, coma, secousses myocloniques), une hypotension réfractaire et une mort subite."},"de":{"name":"Trizyklische Antidepressiva, akute Vergiftung","definition":"Die Vergiftung mit akuten trizyklischen Antidepressiva (TCA) ist eine potenziell letale Intoxikation, die durch lebensbedrohliche Arrhythmien (Sinustachykardien, vorzeitige ventrikuläre Kontraktionen, ventrikuläre Arrhythmien), anticholinerge Vergiftungszeichen (Mydriasis, trockene Schleimhäute, Tachykardie, Hypertonie), Toxizität des zentralen Nervensystems (Lethargie, Koma, myoklonische Zuckungen) sowie refraktäre Hypotonie und plötzlichen Tod gekennzeichnet ist."},"es":{"name":"Intoxicación aguda por antidepresivos tricíclicos","definition":"Es una intoxicación potencialmente letal caracterizada por arritmias potencialmente letales (taquicardias sinusales, contracciones ventriculares prematuras, arritmias ventriculares), síndrome tóxico anticolinérgico (midriasis, sequedad de las membranas mucosas, taquicardia, hipertensión), toxicidad del sistema nervioso central (letargia, coma, espasmo mioclónico), hipotensión refractaria y muerte súbita."},"it":{"name":"Intossicazione acuta da antidepressivi triciclici","definition":"L'avvelenamento acuto da antidepressivi triciclici (TCA) è un'intossicazione, caratterizzata da aritmie potenzialmente letali (tachicardie sinusali, contrazioni ventricolari premature, aritmie ventricolari), sindrome tossica da anticolinergici (midriasi, secchezza delle mucose, tachicardia, ipertensione), tossicità a carico del sistema nervoso centrale (letargia, coma, sussulti mioclonici), ipotensione refrattaria e morte improvvisa."},"nl":{"name":"Acute tricyclisch antidepressivumvergiftiging","definition":"Een zeldzame, potentieel letale intoxicatie, gekarakteriseerd door levensbedreigende aritmieën (sinustachycardieën, premature ventriculaire contracties, ventriculaire aritmieën), anticholinergisch toxidroom (mydriase, droog slijmvlies, tachycardie, hypertensie), vergiftiging van centraal zenuwstelsel (lethargie, coma, myoclonische schokken), refractaire hypotensie, en plots overlijden."},"pt":{"name":"Intoxicação aguda por antidepressivos tricíclicos"},"pl":{"name":"Ostre zatrucie trójcyklicznymi lekami przeciwdepresyjnymi"},"cs":{"name":"Akutní otrava tricyklickými antidepresivy"},"uk":{"name":"Гостре отруєння трициклічними антидепресантами","definition":"A rare, potentially lethal intoxication characterized by life-threatening arrhythmias (sinus tachycardias, premature ventricular contractions, ventricular arrhythmias), anticholinergic toxidrome (mydriasis, dry mucous membrane, tachycardia, hypertension), central nervous system toxicity (lethargy, coma, myoclonic jerks), refractory hypotension and sudden death."},"zh":{"name":"急性三环类抗忧郁药中毒"},"tr":{"name":"Akut trisiklik antidepresan zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T43.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"NE60","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018547","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5681319","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":306640,"name":"Rare intoxication due to medical products","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}