{"orpha":423786,"name":"Undifferentiated carcinoma of stomach","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Undifferentiated gastric carcinoma"],"definition":"Undifferentiated carcinoma of stomach is a rare epithelial tumour of the stomach that lacks any features of differentiation beyond an epithelial phenotype. The presenting symptoms are usually vague and nonspecific, such as weight loss, anorexia, fatigue, epigastric pain and discomfort, heartburn and nausea, vomiting or hematemesis. Patients may also be asymptomatic. Ascites, jaundice, intestinal obstruction and peripheral lymphadenopathy indicate advanced stages and metastatic spread.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-423786/","orphanet_url":"https://www.orpha.net/en/disease/detail/423786","names":{"fr":{"name":"Carcinome indifférencié de l'estomac","synonyms":["Carcinome gastrique indifférencié"],"definition":"Une tumeur épithéliale rare de l'estomac ne montrant pas de signes de différenciation à part le phénotype épithélial. Les signes de présentation sont habituellement vagues et non spécifiques, comme une perte de poids, une anorexie, une fatigue, une douleur et un inconfort épigastriques, des brûlures d'estomac et des nausées, des vomissements ou une hématémèse. Les patients peuvent aussi être asymptomatiques. Une ascite, un ictère, une occlusion intestinale et une lymphadénopathie périphérique indiquent des stades avancés de la tumeur et une dissémination métastatique."},"de":{"name":"Magenkarzinom, undifferenziertes","definition":"Ein seltener epithelialer Tumor des Magens, dem über einen epithelialen Phänotyp hinaus jegliche Differenzierungsmerkmale fehlen. Die präsentierenden Symptome sind in der Regel vage und unspezifisch, wie z. B. Gewichtsverlust, Anorexie, Müdigkeit, epigastrische Schmerzen und Unwohlsein, Sodbrennen und Übelkeit, Erbrechen oder Hämatemesis. Die Patienten können auch asymptomatisch sein. Aszites, Gelbsucht, Darmverschluss und periphere Lymphadenopathie weisen auf fortgeschrittene Stadien und Metastasenausbreitung hin."},"es":{"name":"Carcinoma indiferenciado de estómago","synonyms":["Carcinoma gástrico indiferenciado"],"definition":"Es un tumor epitelial del estómago poco frecuente que carece de cualquiera de las características de diferenciación más allá del fenotipo epitelial. Los síntomas de presentación suelen ser vagos e inespecíficos, tales como pérdida de peso, anorexia, fatiga, dolor y malestar epigástrico, acidez y náuseas, vómitos o hematemesis. Los pacientes pueden también estar asintomáticos. La ascitis, ictericia, obstrucción intestinal y linfadenopatía periférica indican estadios avanzados y diseminación metastásica."},"it":{"name":"Carcinoma non differenziato dello stomaco","synonyms":["Carcinoma gastrico non differenziato"],"definition":"Il carcinoma non differenziato dello stomaco è una neoplasia epiteliale rara che non presenta nessun segno di differenziazione in aggiunta al fenotipo epiteliale. In genere i sintomi sono sfumati ed aspecifici all'esordio (perdita di peso, anoressia, affaticamento, dolore e fastidio epigastrico, bruciore allo stomaco e nausea, vomito o ematemesi). I pazienti possono anche essere asintomatici. La presenza di ascite, ittero, ostruzione intestinale e linfoadenopatia periferica caratterizza gli stadi più avanzati ed è indicativa della presenza di metastasi."},"nl":{"name":"Ongedifferentieerd carcinoom van maag","synonyms":["Ongedifferentieerd gastrisch carcinoom"],"definition":"Ongedifferentieerd carcinoom van de maag is een zeldzame epitheliale maagtumor waarbij enig kenmerk van differentiatie voorbij een epitheliaal fenotype ontbreken. De aanwezige symptomen zijn meestal vaag en niet-specifiek, zoals gewichtsverlies, anorexie, vermoeidheid, epigastrische pijn en ongemakken, maagzuur en misselijkheid, braken of hematemese (bloedbraken). Patiënten kunnen ook asymptomatisch zijn. Ascites, geelzucht, intestinale obstructie en perifere lymfadenopathie wijzen op gevorderde stadia en metastase."},"pt":{"name":"Carcinoma indiferenciado do estômago"},"pl":{"name":"Niezróżnicowany rak żołądka","synonyms":["Undifferentiated gastric carcinoma"]},"cs":{"name":"Nediferencovaný karcinom žaludku","synonyms":["Nediferencovaný žaludeční karcinom"]},"uk":{"name":"Недиференційована карцинома шлунка","synonyms":["Недиференційована карцинома шлунка"],"definition":"Undifferentiated carcinoma of stomach is a rare epithelial tumour of the stomach that lacks any features of differentiation beyond an epithelial phenotype. The presenting symptoms are usually vague and nonspecific, such as weight loss, anorexia, fatigue, epigastric pain and discomfort, heartburn and nausea, vomiting or hematemesis. Patients may also be asymptomatic. Ascites, jaundice, intestinal obstruction and peripheral lymphadenopathy indicate advanced stages and metastatic spread."},"zh":{"name":"胃未分化癌","synonyms":["胃未分化癌"],"definition":"胃未分化癌是一种罕见的胃上皮肿瘤，除了上皮表型外，没有任何分化细胞的特征。呈现的症状通常是模糊的和非特异性的，例如体重减轻，厌食，疲劳，上腹部疼痛和不适，胃灼热和恶心，呕吐或呕血。患者也可能没有症状。腹水，黄疸，肠梗阻和周围淋巴结肿大提示晚期和转移性扩散。"},"tr":{"name":"Farklılaşmamış mide karsinomu","synonyms":["Farklılaşmamış mide karsinomu"]}},"xrefs":[{"source":"ICD-10","code":"C16.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.1","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.2","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.3","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.4","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.5","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.6","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C16.8","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2B72.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018504","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1336858","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":423771,"name":"Rare carcinoma of stomach","classifications":[152,202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.211,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.086,"area":"Austria","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.077,"area":"Belgium","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.764,"area":"Bulgaria","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.068,"area":"Croatia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.328,"area":"Czech Republic","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.743,"area":"Estonia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.002,"area":"Finland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"France","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.221,"area":"Germany","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.085,"area":"Iceland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.009,"area":"Ireland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.399,"area":"Italy","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.571,"area":"Latvia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.877,"area":"Lithuania","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.251,"area":"Malta","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.087,"area":"Norway","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.386,"area":"Poland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.072,"area":"Portugal","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.456,"area":"Slovakia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.013,"area":"Slovenia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.098,"area":"Spain","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.045,"area":"Switzerland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Netherlands","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.032,"area":"United Kingdom","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}