{"orpha":404580,"name":"Polyarticular juvenile idiopathic arthritis","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["Juvenile polyarthritis","Juvenile polyarticular arthritis","Polyarticular JIA"],"definition":"A rare type of juvenile idiopathic arthritis characterized by arthritis with an onset prior to the age of 16 years persisting for longer than six weeks and affecting at least five joints during the first six months of the disease. Other possible causes of joint inflammation must be excluded. Two subgroups of the disease can be distinguished, based on the presence of absence of rheumatoid factor. Both subgroups are more common in girls and may be associated with mild fever, weight loss, anemia, moderate hepatosplenomegaly, and mild growth retardation.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-404580/","orphanet_url":"https://www.orpha.net/en/disease/detail/404580","names":{"fr":{"name":"Arthrite juvénile idiopathique polyarticulaire","synonyms":["AJI polyarticulaire","Polyarthrite juvénile"],"definition":"Type rare d'arthrite juvénile idiopathique caractérisé par une arthrite se manifestant avant l'âge de 16 ans, persistant plus de six semaines et affectant au moins cinq articulations les six premiers mois de la maladie. Il convient d'écarter les autres causes éventuelles d'inflammation articulaire. On distingue deux sous-groupes, en fonction de la présence ou de l'absence du facteur rhumatoïde. Les deux sous-groupes de la maladie sont plus fréquemment rapportés chez les filles et peuvent être associés à une légère fièvre, une perte de poids, une anémie, une hépatosplénomégalie modérée et un léger retard de croissance."},"de":{"name":"Arthritis, idiopathische juvenile, polyartikuläre","synonyms":["Juvenile Polyarthritis","Polyartikuläre JIA","Polyartikuläre juvenile Arthritis"],"definition":"Eine seltene Form der juvenilen idiopathischen Arthritis, die durch eine Arthritis gekennzeichnet ist, die vor dem 16. Lebensjahr beginnt, länger als sechs Wochen andauert und in den ersten sechs Monaten der Erkrankung mindestens fünf Gelenke befällt. Andere mögliche Ursachen der Gelenkentzündung müssen ausgeschlossen sein. Je nachdem, ob ein Rheumafaktor vorhanden ist oder nicht, lassen sich zwei Untergruppen der Erkrankung unterscheiden. Beide Untergruppen treten häufiger bei Mädchen auf und können mit leichtem Fieber, Gewichtsverlust, Anämie, mäßiger Hepatosplenomegalie und leichter Wachstumsverzögerung einhergehen."},"es":{"name":"Artritis idiopática juvenil poliarticular","synonyms":["AIJ poliarticular","Artritis juvenil poliarticular","Poliartritis juvenil"],"definition":"Es un tipo poco frecuente de artritis idiopática juvenil caracterizado por artritis de inicio anterior a los 16 años de edad que persiste durante más de seis semanas y que afecta al menos a cinco articulaciones durante los primeros seis meses de la enfermedad. Deben excluirse otras posibles causas de inflamación articular. Se distingue entre dos subgrupos de la enfermedad en base a la presencia o ausencia del factor reumatoide. Ambos subgrupos son más frecuentes en las niñas y pueden asociarse a fiebre baja, pérdida de peso, anemia, hepatoesplenomegalia moderada y retraso leve del crecimiento."},"it":{"name":"Poliartrite giovanile idiopatica","synonyms":["Artrite poliarticolare giovanile"],"definition":"Si tratta di una forma rara di artrite idiopatica giovanile, caratterizzata da un'artrite che esordisce prima dei 16 anni, persiste per più di sei settimane e interessa almeno cinque articolazioni durante i primi sei mesi dall'insorgenza della malattia. È necessario escludere le altre possibili cause di infiammazione articolare. Si distinguono due sottogruppi della malattia, a seconda della presenza o dell'assenza del fattore reumatoide. Entrambi i sottogruppi sono più comuni nelle femmine e possono associarsi a febbricola, perdita di peso, anemia, epatosplenomegalia moderata e lieve ritardo della crescita."},"nl":{"name":"Polyarticulaire juveniele idiopathische artritis","synonyms":["Juveniele polyarticulaire artritis","Juveniele polyartritis","Polyarticulaire JIA"],"definition":"Een zeldzaam type van juveniele idiopathische artritis, gekarakteriseerd door artritis die aanvangt voor de leeftijd van 16, langer dan zes weken aanhoudt, en minstens vijf gewrichten aantast tijdens de eerste zes maanden van de ziekte. Andere mogelijke oorzaken van gewrichtsontsteking dienen uitgesloten te worden. Er kunnen twee subgroepen van de ziekte onderscheiden worden, op basis van de aan- of afwezigheid van reumafactor. Beide subgroepen komen vaker voor bij meisjes, en kunnen geassocieerd zijn met milde koorts, gewichtsverlies, anemie, matige hepatosplenomegalie, en milde groeiretardatie."},"pt":{"name":"Poliartrite juvenil"},"pl":{"name":"Młodzieńcze idiopatyczne zapalenie wielostawowe","synonyms":["Wielostawowe JIA","Młodzieńcze zapalenie wielostawowe","Młodzieńcze zapalenie wielostawowe"]},"cs":{"name":"Juvenilní polyartritida","synonyms":["Juvenilní polyartikulární artritida"]},"uk":{"name":"Полісуглобовий ювенільний ідіопатичний артрит","synonyms":["Ювенільний поліартрит","Ювенільний поліартикулярний артрит","Поліартикулярний ЮІА"],"definition":"A rare type of juvenile idiopathic arthritis characterized by arthritis with an onset prior to the age of 16 years persisting for longer than six weeks and affecting at least five joints during the first six months of the disease. Other possible causes of joint inflammation must be excluded. Two subgroups of the disease can be distinguished, based on the presence of absence of rheumatoid factor. Both subgroups are more common in girls and may be associated with mild fever, weight loss, anemia, moderate hepatosplenomegaly, and mild growth retardation."},"zh":{"name":"多关节青少年特发性关节炎","synonyms":["幼年多发性关节炎"]},"tr":{"name":"Poliartiküler juvenil idiyopatik artrit","synonyms":["Poliartiküler JIA","jüvenil poliartrit","jüvenil poliartiküler artrit"]}},"xrefs":[{"source":"MONDO","code":"0018456","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18456","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4521004","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":92,"name":"Juvenile idiopathic arthritis","classifications":[184,196,231,233]}],"children":[{"orpha":85408,"name":"Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis","type":"Disease"},{"orpha":85435,"name":"Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}