{"orpha":402035,"name":"Eosinophilic colitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare gastroenterologic disease characterized by extensive eosinophilic infiltration of the colon in the absence of any known cause of secondary intestinal eosinophilia. Patients present with abdominal pain, nausea, vomiting, diarrhea, gastrointestinal bleeding, malabsorption, and/or weight loss. Symptoms do not correlate with the extent of the disease, which can be segmental or pancolonic. Blood testing may show peripheral eosinophilia. The condition has a bimodal age distribution, with a first peak in neonates and a second peak in young adulthood.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-402035/","orphanet_url":"https://www.orpha.net/en/disease/detail/402035","names":{"fr":{"name":"Colite à éosinophiles","synonyms":["Colite éosinophilique"],"definition":"Maladie gastroentérologique rare caractérisée par une infiltration éosinophilique étendue du côlon en l'absence de toute cause connue d'éosinophilie intestinale secondaire. Les patients manifestent des douleurs abdominales, des nausées, des vomissements, des diarrhées, des saignements gastro-intestinaux, une malabsorption et/ou une perte de poids. Les symptômes ne sont pas en corrélation avec l'étendue de la maladie, dont l'atteinte peut être segmentaire ou pancolique. Les analyses sanguines peuvent révéler une éosinophilie périphérique. La répartition par âge est bimodale, avec un premier pic chez les nouveau-nés et un second chez les jeunes adultes."},"de":{"name":"Eosinophile Kolitis","definition":"Eine seltene gastroenterologische Erkrankung, die durch eine ausgedehnte eosinophile Infiltration des Dickdarms gekennzeichnet ist, ohne dass eine Ursache für eine sekundäre intestinale Eosinophilie bekannt ist. Die Patienten präsentieren sich mit Bauchschmerzen, Übelkeit, Erbrechen, Durchfall, gastrointestinalen Blutungen, Malabsorption und/oder Gewichtsverlust. Die Symptome korrelieren nicht mit dem Ausmaß der Erkrankung, die segmental oder pankolonisch sein kann. Bei Bluttests kann eine periphere Eosinophilie festgestellt werden. Die Erkrankung weist eine bimodale Altersverteilung auf, mit einem ersten Höhepunkt bei Neugeborenen und einem zweiten Höhepunkt im jungen Erwachsenenalter."},"es":{"name":"Colitis eosinofílica","definition":"Es una enfermedad gastroenterológica poco frecuente caracterizada por una infiltración eosinofílica extensa en el colon en ausencia de cualquier otra causa conocida de eosinofilia intestinal secundaria. Los pacientes se presentan con dolor abdominal, náuseas, vómitos, diarrea, hemorragia gastrointestinal, malabsorción y/o pérdida de peso. Los síntomas no se correlacionan con la extensión de la enfermedad, que puede ser segmentaria o pancolónica. Los análisis de sangre pueden mostrar eosinofilia periférica. El trastorno presenta una distribución por edades de tipo bimodal, con un primer pico máximo en el periodo neonatal y un segundo en la edad adulta joven."},"it":{"name":"Colite eosinofila","definition":"Si tratta di una malattia gastroenterologica rara, caratterizzata da un'estesa infiltrazione eosinofila del colon, in assenza di cause evidenti di eosinofilia intestinale secondaria. I pazienti presentano dolore addominale, nausea, vomito, diarrea, emorragie gastrointestinali, malassorbimento e/o perdita di peso. I sintomi non correlano con l'estensione della malattia, che può essere segmentale o pancolonica. Gli esami di laboratorio evidenziano una eosinofilia periferica. La distribuzione per età è bimodale, con un primo picco nei neonati e un secondo picco nella prima età adulta."},"nl":{"name":"Eosinofiele colitis","definition":"Een zeldzame gastro-enterologische aandoening, gekarakteriseerd door extensieve eosinofiele infiltratie van colon in afwezigheid van enige gekende oorzaak van secundaire intestinale eosinofilie. Patiënten presenteren zich met abdominale pijn, misselijkheid, braken, diarree, gastro-intestinale bloeding, malabsorptie, en/of gewichtsverlies. Symptomen correleren niet met de omvang van de ziekte, die segmentaal kan zijn of heel colon kan aantasten. Bloedonderzoek toont mogelijk perifere eosinofilie. De aandoening vertoont een bimodale leeftijdsverdeling, met een eerste piek bij neonaten en een tweede piek bij jonge volwassenen."},"pt":{"name":"Colite eosinofílica"},"pl":{"name":"Eozynofilowe zapalenie jelit"},"cs":{"name":"Eosinofilní kolitida"},"uk":{"name":"Еозинофільний коліт","definition":"A rare gastroenterologic disease characterized by extensive eosinophilic infiltration of the colon in the absence of any known cause of secondary intestinal eosinophilia. Patients present with abdominal pain, nausea, vomiting, diarrhea, gastrointestinal bleeding, malabsorption, and/or weight loss. Symptoms do not correlate with the extent of the disease, which can be segmental or pancolonic. Blood testing may show peripheral eosinophilia. The condition has a bimodal age distribution, with a first peak in neonates and a second peak in young adulthood."},"zh":{"name":"嗜酸细胞性结肠炎"},"tr":{"name":"Eozinofilik kolit"}},"xrefs":[{"source":"ICD-10","code":"K52.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DB33.2Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1169803773"},{"source":"MONDO","code":"0018439","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0267448","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10057271","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":402029,"name":"Primary eosinophilic gastrointestinal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult","Infancy"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":196.0,"area":"Worldwide","status":"Validated","source":"22012125[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_22012125[PMID]"}],"phenotypes":null}