{"orpha":399293,"name":"Osteonecrosis of the jaw","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare osteonecrosis characterized by an exposed necrotic lesion in the mandible or maxilla present for more than eight weeks, arising as a complication of antiresorptive medication, dental interventions, or trauma and infections. Patients may present with pain, altered neurosensory functions, secondary infections, and (in advanced stages) pathological fractures, or fistulae.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-399293/","orphanet_url":"https://www.orpha.net/en/disease/detail/399293","names":{"fr":{"name":"Ostéonécrose de la mâchoire","synonyms":["ONM","Ostéochimionécrose de la mâchoire","Ostéochimionécrose maxillaire","Ostéochimionécrose maxillo-mandibulaire","Ostéonécrose des maxillaires","Ostéonécrose maxillaire associée aux biphosphonates"],"definition":"Ostéonécrose rare caractérisée par une lésion nécrotique exposée, au niveau de la mandibule ou du maxillaire, persistant depuis plus de huit semaines, survenant comme une complication de traitements antirésorptifs, d'interventions dentaires, ou de traumatismes et d'infections. Les patients peuvent présenter des douleurs, une altération des fonctions neurosensorielles, des infections secondaires et (à un stade avancé) des fractures pathologiques ou des fistules."},"de":{"name":"Osteonekrose des Kiefers","definition":"Eine seltene Osteonekrose, die durch eine freiliegende nekrotische Läsion im Unter- oder Oberkiefer gekennzeichnet ist, die länger als acht Wochen besteht und als Komplikation von antiresorptiven Medikamenten, zahnärztlichen Eingriffen oder Traumata und Infektionen auftritt. Die Patienten können mit Schmerzen, veränderten neurosensorischen Funktionen, Sekundärinfektionen und (in fortgeschrittenen Stadien) pathologischen Frakturen oder Fisteln auftreten."},"es":{"name":"Osteonecrosis de la mandíbula","definition":"Es una osteonecrosis poco frecuente caracterizada por una lesión necrótica expuesta en la mandíbula o el maxilar superior presente durante más de ocho semanas, que surge como una complicación del tratamiento con agentes antirresortivos, intervenciones dentales o traumatismos e infecciones. Los pacientes pueden presentarse con dolor, alteración de las funciones neurosensoriales, infecciones secundarias y (en estadíos avanzados) fracturas patológicas o fístulas."},"it":{"name":"Osteonecrosi della mascella","definition":"Si tratta di un'osteonecrosi rara caratterizzata da una lesione necrotica esposta nella mandibola o nella mascella, presente per più di otto settimane, che insorge come effetto collaterale dell'assunzione di farmaci antiriassorbimento o come complicanza di interventi odontoiatrici, traumi e infezioni. I pazienti presentano dolore, alterazione delle funzioni neurosensoriali, infezioni secondarie e, nelle fasi più avanzate, fratture patologiche o fistole."},"nl":{"name":"Osteonecrose van kaak","definition":"Een zeldzame osteonecrose, gekarakteriseerd door een blootgestelde necrotische laesie in onderkaak of bovenkaak die langer dan acht weken aanwezig is, ontstaan als complicatie van antiresorptieve medicatie, dentale ingrepen, of trauma en infectie. Patiënten presenteren zich mogelijk met pijn, veranderde neurosensorische functies, secundaire infecties, en (in gevorderde stadia) pathologische fracturen, of fistels."},"pt":{"name":"Osteonecrose da mandíbula"},"pl":{"name":"Osteonekroza szczęki"},"cs":{"name":"Osteonekróza čelisti"},"uk":{"name":"Остеонекроз щелепи","definition":"A rare osteonecrosis characterized by an exposed necrotic lesion in the mandible or maxilla present for more than eight weeks, arising as a complication of antiresorptive medication, dental interventions, or trauma and infections. Patients may present with pain, altered neurosensory functions, secondary infections, and (in advanced stages) pathological fractures, or fistulae."},"zh":{"name":"颌骨坏死","definition":"本病是一种罕见的骨坏死，其特征是下颌骨或上颌骨出现暴露的坏死病变超过8周，是由抗再吸收药物、牙科干预或创伤和感染引起的并发症。患者可能会出现疼痛、神经感觉功能改变、继发性感染和(晚期)病理性骨折或瘘管。"},"tr":{"name":"Çene osteonekrozu"}},"xrefs":[{"source":"ICD-10","code":"K10.2","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"DA06.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"144565066"},{"source":"MONDO","code":"0018378","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2711248","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10064658","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93419,"name":"Rare bone disease"},"parents":[{"orpha":399169,"name":"Secondary avascular necrosis","classifications":[196,199]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}