{"orpha":398109,"name":"Neonatal autoimmune hemolytic anemia","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Neonatal AHA","Neonatal AIHA"],"definition":"A rare, secondary, neonatal autoimmune disease characterized by onset of hemolytic anemia in the neonatal period associated with a positive direct antiglobulin test. Hepatosplenomegaly may be associated.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-398109/","orphanet_url":"https://www.orpha.net/en/disease/detail/398109","names":{"fr":{"name":"Anémie hémolytique auto-immune néonatale","synonyms":["AHA néonatale","AHAI néonatale","AIHA néonatale"],"definition":"Maladie auto-immune néonatale secondaire rare caractérisée par l'apparition d'une anémie hémolytique pendant la période néonatale associée à un test direct à l'antiglobuline positif. Une hépatosplénomégalie peut être associée."},"de":{"name":"Neonatale autoimmune hämolytische Anämie","synonyms":["Neonatales AHA","Neonatales AIHA"]},"es":{"name":"Anemia hemolítica autoinmune neonatal","synonyms":["AHA neonatal","AIHA neonatal"],"definition":"Es una enfermedad autoinmune neonatal secundaria, muy poco frecuente, caracterizada por la aparición de anemia hemolítica en el período neonatal asociada a positividad de la prueba de antiglobulina directa. También puede estar asociada hepatoesplenomegalia."},"it":{"name":"Anemia emolitica autoimmune neonatale","synonyms":["AHA neonatale","AIHA neonatale"],"definition":"L'anemia emolitica autoimmune neonatale è una malattia autoimmune neonatale secondaria molto rara, caratterizzata da anemia emolitica ad esordio neonatale, associata a positività al test diretto dell'antiglobulina. Può associarsi ad epatosplenomegalia."},"nl":{"name":"Neonatale auto-immune hemolytische anemie","synonyms":["Neonatale AHA","Neonatale AIHA"],"definition":"Neonatale auto-immune hemolytische anemie is een zeer zeldzame, secundaire, neonatale auto-immuunziekte die gekarakteriseerd wordt door aanvang van hemolytische anemie in de neonatale periode, geassocieerd met een positieve directe antiglobulinetest. Hepatosplenomegalie kan geassocieerd zijn."},"pt":{"name":"Anemia hemolítica autoimune neonatal"},"pl":{"name":"Autoimmunologiczna niedokrwistość hemolityczna noworodków","synonyms":["AHA noworodków","AIHA noworodków"],"definition":"*Autoimmunologiczna niedokrwistość hemolityczna noworodków jest bardzo rzadką, wtórną, noworodkową chorobą autoimmunologiczną, która charakteryzuje się niedokrwistością hemolityczną o początku w okresie noworodkowym, z dodatnim wynikiem bezpośredniego testu antyglobulinowego. Może towarzyszyć powiększenie wątroby i śledziony."},"cs":{"name":"Neonatální AIHA","synonyms":["Neonatální AHA","Neonatální autoimunitní hemolytická anémie"]},"uk":{"name":"Неонатальна аутоімунна гемолітична анемія","synonyms":["Неонатальний AHA","Неонатальний AIHA"],"definition":"A rare, secondary, neonatal autoimmune disease characterized by onset of hemolytic anemia in the neonatal period associated with a positive direct antiglobulin test. Hepatosplenomegaly may be associated."},"zh":{"name":"新生儿自身免疫性溶血性贫血","synonyms":["新生儿AIHA"],"definition":"新生儿自身免疫性溶血性贫血是一种非常罕见的继发性新生儿自身免疫性疾病，其特征是在新生儿期出现溶血性贫血，并伴有直接抗球蛋白试验阳性。肝脾肿大可与本病相关。"},"tr":{"name":"Yenidoğan otoimmün hemolitik anemisi","synonyms":["Yenidoğan AHA","Yenidoğan AIHA"]}},"xrefs":[{"source":"ICD-10","code":"D59.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"3A20.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018358","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4751517","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":398091,"name":"Secondary neonatal autoimmune disease","classifications":[196,231]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Neonatal"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":2.0,"area":"Worldwide","status":"Validated","source":"12819171[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_12819171[PMID]"}],"phenotypes":null}