{"orpha":396,"name":"Chronic hiccup","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Chronic hiccup is a rare movement disorder characterized by involuntary spasmodic contractions of the inspiratory muscles synchronized with larynx closure lasting for more than 48 hours.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-396/","orphanet_url":"https://www.orpha.net/en/disease/detail/396","names":{"fr":{"name":"Hoquet chronique","definition":"Secousses répétitives caractérisées par des contractions spasmodiques involontaires des muscles inspiratoires synchronisées avec la fermeture du larynx, persistant au-delà de 48 heures."},"de":{"name":"Singultus, chronischer","synonyms":["Schluckauf, chronischer"]},"es":{"name":"Hipo crónico","definition":"Es un trastorno poco frecuente del movimiento caracterizado por contracciones espasmódicas involuntarias de los músculos inspiratorios sincronizadas con el cierre de la laringe que duran más de 48 horas."},"it":{"name":"Singhiozzo cronico","synonyms":["Singulto cronico"]},"nl":{"name":"Chronische hik","synonyms":["Chronisch hikken"],"definition":"Chronische hik is een zeldzame bewegingsstoornis die gekenmerkt wordt door onvrijwillige spasmodische contracties van de inademingsspieren gesynchroniseerd met sluiting van de larynx die meer dan 48 uur aanhoudt."},"pt":{"name":"Soluços crónicos","definition":"O soluço crónico é uma perturbação do movimento rara, caracterizada por contrações espasmódicas involuntárias dos músculos inspiratórios, sincronizadas com o fecho da laringe, com duração superior a 48 horas."},"pl":{"name":"Czkawka przewlekła"},"cs":{"name":"Chronická škytavka"},"uk":{"name":"Хронічна гикавка","definition":"Chronic hiccup is a rare movement disorder characterized by involuntary spasmodic contractions of the inspiratory muscles synchronized with larynx closure lasting for more than 48 hours."},"zh":{"name":"慢性嗝逆"},"tr":{"name":"Kronik hıçkırık"}},"xrefs":[{"source":"ICD-10","code":"G25.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8A06.21","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1300687612"},{"source":"MONDO","code":"0018334","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0744898","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6657","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":423662,"name":"Rare autonomic nervous system disorder","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.0,"area":"Europe","status":"Validated","source":"[EXPERT]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2018-09-05","source":"28759492[PMID]_1477559[PMID]","terms":[{"hpo":"HP:0100247","label":"Recurrent singultus","frequency":"Very frequent (99-80%)","criteria":"Pathognomonic sign"},{"hpo":"HP:0100738","label":"Abnormal eating behavior","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000775","label":"Abnormality of the diaphragm","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001944","label":"Dehydration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004395","label":"Malnutrition","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002360","label":"Sleep abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null}]}}