{"orpha":391490,"name":"Adult-onset myasthenia gravis","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Adult-onset acquired myasthenia","Adult-onset autoimmune myasthenia gravis"],"definition":"A rare autoimmune disorder of the neuromuscular junction characterized by fatigable muscle weakness with frequent ocular signs and/or generalized muscle weakness, and occasionally associated with thymoma.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-391490/","orphanet_url":"https://www.orpha.net/en/disease/detail/391490","names":{"fr":{"name":"Myasthénie auto-immune de l'adulte","synonyms":["Myasthenia gravis de l'adulte","Myasthénie acquise de l'adulte"],"definition":"Maladie auto-immune rare de la jonction neuromusculaire caractérisée par une faiblesse et une fatigabilité musculaires accompagnées de manifestations oculaires fréquents et/ou d'une faiblesse musculaire généralisée, parfois associée à un thymome."},"de":{"name":"Myasthenia gravis mit Beginn im Erwachsenenalter","synonyms":["Autoimmune Myasthenia gravis mit Beginn im Erwachsenenalter","Erworbene Myasthenie mit Beginn im Erwachsenenalter"]},"es":{"name":"Miastenia grave de inicio en el adulto","synonyms":["Miastenia adquirida de inicio en el adulto","Miastenia grave autoinmune de inicio en el adulto"],"definition":"Es un trastorno autoinmune de la unión neuromuscular poco frecuente caracterizado por debilidad muscular fatigable con signos oculares frecuentes y/o debilidad muscular generalizada, junto con asociación ocasional a timoma."},"it":{"name":"Miastenia gravis a esordio nell'età adulta","synonyms":["Miastenia acquisita a esordio nell'età adulta","Miastenia grave autoimmune a esordio nell'età adulta","Miastenia gravis autoimmune a esordio nell'età adulta"]},"nl":{"name":"Myasthenia gravis met aanvang op volwassen leeftijd","synonyms":["Auto-immune myasthenia gravis met volwassen aanvang","Verworven myasthenie met volwassen aanvang"],"definition":"Een zeldzame auto-immuunziekte van neuromusculaire overgang, gekarakteriseerd door spierzwakte die onderhevig is aan vermoeidheid, met regelmatig oculaire indicaties en/of gegeneraliseerde spierzwakte, en soms geassocieerd met thymoom."},"pt":{"name":"Miastenia gravis com início no adulto"},"pl":{"name":"Miastenia o początku w wieku dorosłym","synonyms":["Miastenia autoimmunologiczna o początku w wieku dorosłym","Miastenia nabyta o początku w wieku dorosłym"]},"cs":{"name":"Adultní forma myasthenia gravis","synonyms":["Adultní získaná myastenie","Autoimunitní myasthenia gravis s nástupem v dospělosti"]},"uk":{"name":"Miastenia gravis з дебютом у дорослому віці","synonyms":["Набута у дорослому віці міастенія","Автоімунна міастенія, що починається у дорослих"],"definition":"A rare autoimmune disorder of the neuromuscular junction characterized by fatigable muscle weakness with frequent ocular signs and/or generalized muscle weakness, and occasionally associated with thymoma."},"zh":{"name":"成人起病重症肌无力","synonyms":["成人起病自身免疫性重症肌无力"],"definition":"本病是一种罕见的神经肌肉交界处的自身免疫性疾病，以疲劳性肌无力为特征，伴有频繁的眼部症状和/或全身性肌肉无力，偶尔还伴有胸腺瘤。"},"tr":{"name":"Erişkin başlangıçlı myastenia gravis","synonyms":["Erişkin-başlangıçlı edinsel miyasteni","Erişkin-başlangıçlı otoimmün miyastenia gravis"]}},"xrefs":[{"source":"ICD-10","code":"G70.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8C60","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018324","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5680024","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":589,"name":"Myasthenia gravis","classifications":[181,189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial","Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":31.8,"area":"Serbia","status":"Validated","source":"23363926[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.33,"area":"Serbia","status":"Validated","source":"23363926[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":17.0,"area":"United States","status":"Validated","source":"[EXPERT]_ORPHANET"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":28.0,"area":"United Kingdom","status":"Validated","source":"[EXPERT]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET"}],"phenotypes":null}