{"orpha":37202,"name":"Interstitial cystitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Bladder pain syndrome","IC/BPS","IC/PBS","Interstitial cystitis/bladder pain syndrome","Interstitial cystitis/painful bladder syndrome","Painful bladder syndrome"],"definition":"A rare non-infectious, chronic and most often progressive disease of the urinary bladder. It is characterized by varying combinations and extent of pain, urinary frequency (pollakisuria), nocturia and urgency. Interstitial cystitis (IC) has a broad intersection with Bladder Pain Syndrome (BPS) and Overactive Bladder (OAB).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-37202/","orphanet_url":"https://www.orpha.net/en/disease/detail/37202","names":{"fr":{"name":"Syndrome douloureux vésical","synonyms":["Cystite interstitielle","IC/BPS","IC/PBS","Syndrome de la douleur vésicale","Syndrome de la vessie douloureuse"],"definition":"Maladie rare, non infectieuse, chronique, le plus souvent progressive de la vessie. Elle se caractérise par une combinaison et une intensité variables de douleur, de fréquence urinaire (pollakiurie), de nycturie et de besoin impérieux d'uriner. La cystite interstitielle (CI) recoupe largement le syndrome de la douleur vésicale (SPV) et l'hyperactivité vésicale (HAV)."},"de":{"name":"Interstitielle Cystitis","synonyms":["Blasenschmerz-Syndrom","IC/BPS","Interstitielle Cystitis/Blasenschmerzsyndrom","Interstitielle Zystitis"],"definition":"Eine seltene, nicht-infektiöse, chronische und meist progrediente Erkrankung der Harnblase. Sie ist durch unterschiedliche Kombinationen und Ausmaße von Schmerzen, Häufigkeit des Wasserlassens (Pollakisurie), Nykturie und Harndrang gekennzeichnet. Die interstitielle Zystitis (IC) hat eine große Schnittmenge mit dem Blasenschmerzsyndrom (BPS) und der überaktiven Blase (OAB)."},"es":{"name":"Cistitis intersticial","synonyms":["SDV/CI","SVD/CI","Síndrome de dolor vesical","Síndrome de dolor vesical/cistitis intersticial","Síndrome de vejiga dolorosa","Síndrome de vejiga dolorosa/cistitis intersticial"],"definition":"Es una enfermedad crónica no infecciosa poco frecuente de la vejiga, y a menudo progresiva. Se caracteriza por combinaciones variables de dolor, frecuencia urinaria (polaquiuria), urgencia urinaria y nicturia. La cistitis intersticial (CI) se solapa en gran medida con el síndrome de dolor vesical (SDV) y la vejiga hiperactiva (VH)."},"it":{"name":"Cistite interstiziale","synonyms":["Sindrome della vescica dolorosa"],"definition":"La cistite interstiziale (IC) è una malattia rara cronica e spesso progressiva, non infettiva della vescica. È caratterizzata da dolore, aumento della frequenza della minzione (pollachiuria), nicturia e urgenza minzionale di grado variabile. La IC si sovrappone ampiamente alla sindrome della vescica dolorosa (BPS) e alla vescica iperattiva (OAB)."},"nl":{"name":"Interstitiële cystitis","synonyms":["Blaaspijnsyndroom","IC/BPS","IC/PBS","Interstitiële cystitis/blaaspijnsyndroom","Interstitiële cystitis/pijnlijke blaassyndroom","Pijnlijke blaassyndroom"],"definition":"Een zeldzame niet-infectieuze, chronische en meestal progressieve aandoening van urineblaas. De ziekte wordt gekenmerkt door variabele combinaties en gradaties van pijn, verhoogde frequentie van mictie (pollakisurie), nycturie en urgente mictiedrang. Interstitiële cystitis (IC) vertoont grote overlap met blaaspijnsyndroom (BPS) en overactieve blaas (OAB)."},"pt":{"name":"Cistite intersticial"},"pl":{"name":"Śródmiąższowe zapalenie pęcherza moczowego","synonyms":["IC/BPS","IC/PBS","Zespół bólu pęcherza","Zespół bolesnego pęcherza"]},"cs":{"name":"Intersticiální cystitida","synonyms":["Syndrom bolesti močového měchýře","Syndrom bolestivého měchýře"]},"uk":{"name":"Інтерстиціальний цистит","synonyms":["Больовий синдром у сечовому міхурі","IC/BPS","IC/PBS","Інтерстиціальний цистит/больовий синдром сечового міхура","Інтерстиціальний цистит/синдром хворобливого сечового міхура","Синдром хворобливого сечового міхура"],"definition":"A rare non-infectious, chronic and most often progressive disease of the urinary bladder. It is characterized by varying combinations and extent of pain, urinary frequency (pollakisuria), nocturia and urgency. Interstitial cystitis (IC) has a broad intersection with Bladder Pain Syndrome (BPS) and Overactive Bladder (OAB)."},"zh":{"name":"间质性膀胱炎","synonyms":["间质性膀胱炎/膀胱疼痛综合征"]},"tr":{"name":"İnterstisyel sistit","synonyms":["IC/BPS","IC/PBS","Mesane ağrısı sendromu","Ağrılı mesane sendromu","İnterstisyel sistit/mesane ağrısı sendromu","İnterstisyel sistit/ağrılı mesane sendromu"]}},"xrefs":[{"source":"ICD-10","code":"N30.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"GC00.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1650709285"},{"source":"MONDO","code":"0018301","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D018856","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0282488","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10011796","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":101433,"name":"Rare urogenital disease"},"parents":[{"orpha":101433,"name":"Rare urogenital disease","classifications":[185]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET_1137336[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.6,"area":"Finland","status":"Validated","source":"1137336[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":30.0,"area":"United States","status":"Validated","source":"ISBN:978-4471-3295-0[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.66,"area":"Finland","status":"Validated","source":"1137336[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-09-22","source":"34033350[PMID]_22057291[PMID]","terms":[{"hpo":"HP:0000014","label":"Abnormality of the bladder","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000078","label":"Abnormality of the genital system","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000058","label":"Abnormality of the labia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000140","label":"Abnormality of the menstrual cycle","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000795","label":"Abnormality of the urethra","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0030016","label":"Dyspareunia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100518","label":"Dysuria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000009","label":"Functional abnormality of the bladder","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000017","label":"Nocturia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0034267","label":"Pelvic pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100515","label":"Pollakisuria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100577","label":"Urinary bladder inflammation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000012","label":"Urinary urgency","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011118","label":"Abnormality of tumor necrosis factor secretion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000142","label":"Abnormality of the vagina","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0500005","label":"Anal pain","frequency":"Occasional (29-5%)","criteria":null}]}}