{"orpha":35889,"name":"Acute opioid intoxication","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-35889/","orphanet_url":"https://www.orpha.net/en/disease/detail/35889","names":{"fr":{"name":"Intoxication aiguë par les opioïdes","definition":"Intoxication rare aux opioïdes, un important groupe d'alcaloïdes à effet analgésique, principalement caractérisée par le myosis (pupille punctiforme), la dépression respiratoire (bradypnée/apnée) et la dépression du système nerveux central (sédation ou coma). Les autres manifestations sont l'hypotension, une diminution de la motilité intestinale, l'hypothermie et l'hypoglycémie. La naloxone, un inhibiteur compétitif des récepteurs opiacés mu (µ), est un puissant antagoniste utilisé comme antidote en cas d'intoxication par les opioïdes."},"de":{"name":"Opiat-Vergiftung, akute","definition":"Die akute Opioidvergiftung ist eine seltene Intoxikation mit Opioiden, einer großen Gruppe von Alkaloidanalgetika, die hauptsächlich durch Miosis (punktförmige Pupille), Atemdepression (Bradypnoe / Apnoe) und Depression des Zentralnervensystems (Sedation oder Koma) gekennzeichnet sind. Andere Manifestationen umfassen Hypotonie, reduzierte Darmmotilität, Hypothermie und Hypoglykämie. Naloxon, ein kompetitiver Inhibitor des mu-Opioid-Rezeptors, ist ein potenter Antagonist und wird als Gegenmittel für Opioid-Intoxikationen eingesetzt."},"es":{"name":"Intoxicación aguda por opioides","definition":"Es una intoxicación poco frecuente por un grupo de analgésicos alcaloides que se caracteriza principalmente por miosis (pupilas puntiformes), depresión respiratoria (bradipnea / apnea) y depresión del sistema nervioso central (sedación o coma). Otras manifestaciones posibles incluyen hipotensión, motilidad intestinal reducida, hipotermia e hipoglucemia. La naloxona, un inhibidor competitivo del receptor opioide mu, es un potente antagonista de este receptor, por lo que se utiliza como antídoto para la intoxicación por opioides."},"it":{"name":"Intossicazione acuta da oppioidi","definition":"L'avvelenamento acuto da oppioidi è un'intossicazione rara da oppioidi, un'ampia classe di analgesici alcaloidi. L'intossicazione esordisce prevalentemente con miosi (pupilla a punta di spillo), depressione respiratoria (bradipnea/apnea) e depressione del sistema nervoso centrale (sedazione o coma). Altri segni clinici comprendono l'ipotensione, la ridotta motilità intestinale, l'ipotermia e l'ipoglicemia. Il naloxone, un inibitore competitivo del recettore mu-oppioide, è un antagonista efficace che viene utilizzato come antidoto nell'intossicazione da oppioidi."},"nl":{"name":"Acute intoxicatie door opioïd","definition":"Een zeldzame intoxicatie met opioïden, een grote groep van alkaloïde analgetica, voornamelijk gekarakteriseerd door miose (zeer vernauwde pupillen), respiratoire depressie (bradypneu/apneu) en depressie van centraal zenuwstelsel (sedatie of coma). Andere manifestaties zijn onder meer hypotensie, verminderde darmmotiliteit, hypothermie en hypoglycemie. Nalaxon, een competitieve inhibitor van de mu-opioïd-receptor, is een potente antagonist en wordt gebruikt als tegengif voor opioïdevergiftiging."},"pt":{"name":"Intoxicação aguda por opióides"},"pl":{"name":"Ostre zatrucie opioidami"},"cs":{"name":"Akutní intoxikace opiáty"},"uk":{"name":"Гостра опіоїдна інтоксикація","definition":"A rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication."},"zh":{"name":"急性阿片中毒"},"tr":{"name":"Akut opioid zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T40.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"T40.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"T40.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"6C43.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1395283456"},{"source":"MONDO","code":"0018173","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18173","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5848046","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}