{"orpha":35807,"name":"Malignant germ cell tumor of ovary","type":"Category","group":"Group of disorders","status":"active","flags":[],"synonyms":["MOGCT","Malignant ovarian germ cell tumor","Ovarian germ cell cancer"],"definition":"Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-35807/","orphanet_url":"https://www.orpha.net/en/disease/detail/35807","names":{"fr":{"name":"Tumeur maligne ovarienne germinale","synonyms":["Cancer germinal de l'ovaire","MOGCT"],"definition":"Tumeur germinale ovarienne rare issue des cellules germinales de l'ovaire, souvent unilatérale au moment du diagnostic, se manifestant typiquement à l'adolescence par une masse pelvienne, de la fièvre, des saignements vaginaux et une symptomatologie abdominale aiguë."},"de":{"name":"Maligne Keimzelltumoren des Ovars","synonyms":["Keimzelltumor, maligner ovarieller","MOGCT"],"definition":"Der maligne Keimzelltumor des Eierstocks ist eine seltene Form von Eierstockkrebs, der von den Keimzellen im Eierstock ausDer maligne Keimzelltumor des Eierstocks ist eine seltene Form von Eierstockkrebs, der von den Keimzellen im Eierstock ausgeht. Bei der Diagnose ist er häufig einseitig und äußert sich typischerweise in der Pubertät durch eine Gewebeverdichtung im Becken, Fieber, vaginale Blutungen und akutes Abdomen.geht. Bei der Diagnose ist er häufig einseitig und äußert sich typischerweise in der Pubertät durch eine Gewebeverdichtung im Becken, Fieber, vaginale Blutungen und akutes Abdomen."},"es":{"name":"Tumor maligno de ovario de células germinales","synonyms":["Cáncer de ovario de células germinales","MOGCT","Tumor maligno ovárico de células germinales"],"definition":"Es un cáncer de ovario poco frecuente que se origina en las células germinales del ovario, con frecuencia unilateral en el momento del diagnóstico y que se suele presentar durante la adolescencia con una masa pélvica, fiebre, sangrado vaginal y abdomen agudo."},"it":{"name":"Tumore maligno dell'ovaio a cellule germinali","synonyms":["Cancro ovarico a cellule germinali","MOGCT","Tumore ovarico maligno a cellule germinali"]},"nl":{"name":"Maligne kiemceltumor van ovarium","synonyms":["MOGCT","Maligne kiemceltumor van eierstok","Maligne ovariële kiemceltumor","Ovariële kiemceltumor"],"definition":"Maligne kiemceltumor van het ovarium is een zeldzame ovariumkanker (zie deze term) die ontstaat uit kiemcellen in het ovarium en meestal unilateraal voorkomt bij de diagnose. De ziekte uit zich typisch tijdens de adolescentie met zwelling in het bekken, vaginale bloedingen en acute buik."},"pt":{"name":"Tumor maligno das células da linha germinativa do ovário"},"pl":{"name":"Złośliwy nowotwór komórek germinalnych jajnika","synonyms":["MOGCT","Rak komórek germinalnych jajnika"]},"cs":{"name":"Maligní germinální nádory ovaria","synonyms":["MOGCT","Maligní ovariální germinální nádor","Ovariální germinální rakovina"]},"uk":{"name":"Злоякісна герміногенна пухлина яєчника","synonyms":["Злоякісна герміногенна пухлина яєчників","MOGCT","Рак зародкових клітин яєчників"],"definition":"Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen."},"zh":{"name":"恶性卵巢生殖细胞肿瘤","synonyms":["卵巢恶性生殖细胞肿瘤"]},"tr":{"name":"Yumurtalıkların habis germ hücreli tümörü","synonyms":["MOGCT","Yumurtalık germ hücre kanseri","Habis yumurtalık germ hücre tümörü"]}},"xrefs":[{"source":"OMIM","code":"603737","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-11","code":"2C73.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"944929842"},{"source":"MONDO","code":"0018171","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18171","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C562841","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0346180","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9330","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10061893","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":363582,"name":"Gonadal germ cell tumor","classifications":[202,233]},{"orpha":398940,"name":"Malignant non-epithelial tumor of ovary","classifications":[202,205]}],"children":[{"orpha":206538,"name":"Malignant non-dysgerminomatous germ cell tumor of ovary","type":"Disease"},{"orpha":99912,"name":"Ovarian dysgerminoma","type":"Disease"},{"orpha":289356,"name":"Primary non-gestational choriocarcinoma of ovary","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["Adolescent","Adult","Childhood","Elderly","Infancy"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Lifetime Prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":2.3,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"United States","status":"Validated","source":"15863154[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.072,"area":"Austria","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.07,"area":"Belgium","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.089,"area":"Bulgaria","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.093,"area":"Croatia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.087,"area":"Czech Republic","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.062,"area":"Finland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.065,"area":"Germany","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.085,"area":"Iceland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.065,"area":"Ireland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.065,"area":"Italy","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.081,"area":"Latvia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.095,"area":"Lithuania","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.09,"area":"Norway","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.098,"area":"Poland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.064,"area":"Portugal","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.075,"area":"Slovenia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.072,"area":"Spain","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.051,"area":"Switzerland","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.061,"area":"Netherlands","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.064,"area":"United Kingdom","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.157,"area":"Estonia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.126,"area":"Malta","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.141,"area":"Slovakia","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}