{"orpha":3388,"name":"Neural tube defect","type":"Category","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":null,"note":"This term does not characterize a disease but a group of diseases. To learn about the diseases included under this term, you can consult the classifications.","url":"https://raremap.alftech.space/d/ORPHA-3388/","orphanet_url":"https://www.orpha.net/en/disease/detail/3388","names":{"fr":{"name":"Anomalie du tube neural"},"de":{"name":"Neuralrohrdefekt"},"es":{"name":"Anomalías del tubo neural"},"it":{"name":"Anomalie di chiusura del tubo neurale"},"nl":{"name":"Neuralebuisdefect"},"pt":{"name":"Defeito do tubo neural"},"pl":{"name":"Wada cewy nerwowej"},"cs":{"name":"Defekt neurální trubice"},"uk":{"name":"Дефект нервової трубки"},"zh":{"name":"神经管缺损"},"tr":{"name":"Nöral tüp defekti"}},"xrefs":[{"source":"MONDO","code":"0018075","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18075","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009436","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0027794","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10052046","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":98044,"name":"Central nervous system malformation","classifications":[147,181]},{"orpha":183506,"name":"Genetic central nervous system malformation","classifications":[156]}],"children":[{"orpha":268843,"name":"Malformation of the neurenteric canal, spinal cord and column","type":"Category"},{"orpha":268357,"name":"Neural tube closure defect","type":"Category"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":55.0,"area":"United States","status":"Validated","source":"Center for Diseases Control and Prevention 2004[OTHER]_26108864[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":91.05,"area":"Europe","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":88.75,"area":"Belgium","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":76.8,"area":"Austria","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2009[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":74.7,"area":"Czech Republic","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 2000-2009[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":47.9,"area":"Croatia","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":109.6,"area":"Denmark","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":86.7,"area":"Finland","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1993-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":120.2,"area":"France","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":138.25,"area":"Germany","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":67.2,"area":"Hungary","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1998-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":87.4,"area":"Ireland","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":54.65,"area":"Italy","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":109.5,"area":"Malta","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":84.2,"area":"Netherlands","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":92.7,"area":"Norway","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1999-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":92.5,"area":"Poland","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1999-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":47.3,"area":"Portugal","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":98.5,"area":"Spain","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":101.7,"area":"Switzerland","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":115.5,"area":"United Kingdom","status":"Validated","source":"26601850[PMID]_EUROCAT European surveillance of congenital anomalies 1991-2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":1387.0,"area":"China","status":"Validated","source":"16575897[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":31.0,"area":"Brazil","status":"Validated","source":"23990401[PMID]"}],"phenotypes":null}