{"orpha":330021,"name":"Mercury poisoning","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Hydrargyria","Mercurialism","Mercury intoxication"],"definition":"Mercury poisoning is caused mainly through ingestion or inhalation of any of the 3 forms of mercury, elemental, organic, and inorganic. Exposure to elemental mercury affects the pulmonary (inhalation of mercury vapors causes coughing, chills, fever, shortness of breath), dermatological (mild swelling, vesiculation, scaling, irritation, urticaria, erythema and allergic contact dermatitis accompanied by pain), and peripheral and central nervous (CNS) systems (depression, paranoia, extreme irritability, hallucinations, inability to concentrate, memory loss, hands, head, lips, tongue, jaw and eyelids tremors, weight loss, perpetually low body temperature, drowsiness, headaches, insomnia, fatigue). Exposure to inorganic mercury generally causes development of a metallic taste, local oropharyngeal pain, nausea, vomiting, bloody diarrhea, colic abdominal pain, renal dysfunction and, neurologic abnormalities; while that to organic mercury can lead to delayed neurotoxicity.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-330021/","orphanet_url":"https://www.orpha.net/en/disease/detail/330021","names":{"fr":{"name":"Intoxication au mercure","synonyms":["Hydrargyrie","Mercurialisme"],"definition":"Survient principalement à la suite de l'ingestion ou de l'inhalation de l'une des trois formes de mercure, élémentaire, organique et inorganique. L'exposition au mercure élémentaire affecte les poumons (l'inhalation de vapeurs de mercure provoque toux, frissons, fièvre, essoufflement), la peau (léger gonflement, vésiculation, desquamation, irritation, urticaire, érythème et dermatite de contact allergique accompagnée de douleur), et le système nerveux périphérique et central (SNC) (dépression, paranoïa, irritabilité extrême, hallucinations, incapacité à se concentrer, perte de mémoire, tremblements des mains, de la tête, des lèvres, de la langue, de la mâchoire et des paupières, perte de poids, persistance d'une température corporelle basse, somnolence, maux de tête, insomnie, fatigue). L'exposition au mercure inorganique provoque généralement l'apparition d'un goût métallique, de douleurs oropharyngées localisées, de nausées, de vomissements, de diarrhées sanglantes, de douleurs abdominales coliques, d'un dysfonctionnement rénal et de troubles neurologiques, tandis que l'exposition au mercure organique peut entraîner une toxicité neurologique tardive."},"de":{"name":"Quecksilbervergiftung","synonyms":["Merkurialismus","Quecksilber-Intoxikation"]},"es":{"name":"Intoxicación por mercurio","synonyms":["Envenenamiento por mercurio","Hidrargiria","Mercurialismo"],"definition":"Se produce principalmente por ingestión o inhalación de cualquiera de las 3 formas de mercurio: elemental, orgánico e inorgánico. La exposición al mercurio elemental afecta a los pulmones (la inhalación de vapores de mercurio provoca tos, escalofríos, fiebre, dificultad respiratoria) y a la piel (leve inflamación, vesiculación, descamación, irritación, urticaria, eritema y dermatitis alérgica de contacto acompañada de dolor), así como al sistema nervioso periférico y central (depresión, paranoia, irritabilidad extrema, alucinaciones, incapacidad para concentrarse, pérdida de memoria, temblor de manos, cabeza, labios, lengua, mandíbula y párpados, pérdida de peso, baja temperatura corporal, somnolencia, cefaleas, insomnio, fatiga). La exposición al mercurio inorgánico provoca, por lo general, el desarrollo de un sabor metálico, dolor orofaríngeo localizado, náuseas, vómitos, diarrea sanguinolenta, dolor cólico abdominal, disfunción renal y anomalías neurológicas; mientras que el mercurio orgánico puede derivar en neurotoxicidad retardada."},"it":{"name":"Avvelenamento da mercurio","synonyms":["Mercurialismo","Idrargiria","Intossicazione da mercurio"],"definition":"L'avvelenamento da mercurio di solito è causato dall'ingestione o dall'inalazione di mercurio in una delle sue tre forme (allo stato elementare, organico e inorganico). L'esposizione al mercurio allo stato elementare colpisce il sistema respiratorio (l'inalazione dei suoi vapori causa tosse, brividi, febbre e affanno), la cute (lieve gonfiore, comparsa di vesciche, desquamazione, irritazione, orticaria, eritema e dermatite allergica da contatto associata a dolore), il sistema nervoso centrale (SNC) e periferico (depressione, paranoia, irritabilità marcata, allucinazioni, incapacità di concentrazione, perdita di memoria, tremori delle mani, della testa, delle labbra, della lingua, della mascella e delle palpebre, perdita di peso, temperatura corporea costantemente bassa, sonnolenza, cefalea, insonnia, affaticamento). L'esposizione al mercurio inorganico di solito causa lo sviluppo di un gusto metallico, dolore orofaringeo localizzato, nausea, vomito, diarrea emorragica, dolore addominale di tipo colico, disfunzione renale e anomalie neurologiche. L'esposizione al mercurio organico esita in una neurotossicità ritardata."},"nl":{"name":"Kwikvergiftiging","synonyms":["Hydrargyria","Kwikintoxicatie","Mercurialisme"],"definition":"Kwikvergiftiging wordt voornamelijk veroorzaakt door ingestie of inademing van een van de 3 vormen van kwik, zijnde elementair, organisch en anorganisch. Blootstelling aan elementair kwik treft de pulmonale (inademing van kwikdampen veroorzaakt hoesten, rillingen, koorts, kortademigheid), dermatologische (milde zwelling, vesiculatie (blaarvorming), afschilfering, irritatie, urticaria (netelroos), erytheem en allergische contactdermatitis vergezeld door pijn), en perifere en centrale zenuwstelsel (CZS) systemen (depressie, paranoia, extreme prikkelbaarheid, hallucinaties, concentratieproblemen, geheugenverlies, tremor aan handen, hoofd, lippen, tong, kaak en oogleden, gewichtsverlies, constant lage lichaamstemperatuur, slaperigheid, hoofdpijn, slapeloosheid, vermoeidheid). Blootstelling aan anorganisch kwik veroorzaakt doorgaans ontwikkeling van een metaalachtige smaak, lokale orofaryngeale pijn, misselijkheid, braken, bloederige diarree, koliekachtige buikpijn, nierdysfunctie, en neurologische afwijkingen, terwijl blootstelling aan organisch kwik kan leiden tot een vertraagde vorm van neurotoxiciteit."},"pt":{"name":"Envenenamento por mercúrio","synonyms":["Hidrargiria","Intoxicação por mercúrio","Mercurialismo"]},"pl":{"name":"Zatrucie rtęcią","synonyms":["Intoksykacja rtęcią","Merkurializm","Rtęcica"]},"cs":{"name":"Otrava rtutí","synonyms":["Hydrargyria","Mercurialism","Mercury intoxication"]},"uk":{"name":"Отруєння ртуттю","synonyms":["Гідраргірія","Меркуріалізм","Ртутна інтоксикація"],"definition":"Mercury poisoning is caused mainly through ingestion or inhalation of any of the 3 forms of mercury, elemental, organic, and inorganic. Exposure to elemental mercury affects the pulmonary (inhalation of mercury vapors causes coughing, chills, fever, shortness of breath), dermatological (mild swelling, vesiculation, scaling, irritation, urticaria, erythema and allergic contact dermatitis accompanied by pain), and peripheral and central nervous (CNS) systems (depression, paranoia, extreme irritability, hallucinations, inability to concentrate, memory loss, hands, head, lips, tongue, jaw and eyelids tremors, weight loss, perpetually low body temperature, drowsiness, headaches, insomnia, fatigue). Exposure to inorganic mercury generally causes development of a metallic taste, local oropharyngeal pain, nausea, vomiting, bloody diarrhea, colic abdominal pain, renal dysfunction and, neurologic abnormalities; while that to organic mercury can lead to delayed neurotoxicity."},"zh":{"name":"汞中毒","synonyms":["Hydrargyria","Mercurialism","Mercury intoxication"],"definition":"汞中毒主要是通过摄入或吸入三种形式的汞（元素、有机和无机）引起的。接触元素汞会影响肺部（吸入汞蒸气会导致咳嗽、畏寒、发热、气短）、皮肤病（轻度肿胀、水疱、结垢、刺激、荨麻疹、红斑和过敏性接触性皮炎伴疼痛）以及外周和中枢神经系统（抑郁、偏执，极度易怒、幻觉、注意力不集中、记忆力减退、手、头、唇、舌、下巴和眼睑颤抖、体重减轻、体温持续偏低、嗜睡、头痛、失眠、疲劳）。接触无机汞通常会引起金属味、局部口咽疼痛、恶心、呕吐、血性腹泻、绞痛性腹痛、肾功能不全和神经系统异常；而接触有机汞可导致迟发性神经毒性。"},"tr":{"name":"Cıva zehirlenmesi","synonyms":["Civa zehirlenmesi","Merkürlülük","Cıva zehirlenmesi"]}},"xrefs":[{"source":"ICD-10","code":"T56.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1880611519"},{"source":"MONDO","code":"0018020","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008630","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0025427","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7021","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2012[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-12-22","source":"26807265[PMID]_26678598[PMID]","terms":[{"hpo":"HP:0002500","label":"Abnormal cerebral white matter morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001332","label":"Dystonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002574","label":"Episodic abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002572","label":"Episodic vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003324","label":"Generalized muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002900","label":"Hypokalemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006515","label":"Interstitial pneumonitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007185","label":"Loss of consciousness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Frequent (79-30%)","criteria":null}]}}