{"orpha":329967,"name":"Intermittent hydrarthrosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare rheumatologic disease characterized by recurrent self-remitting episodes of acute monoarticular arthritis, often with a fixed periodicity, typically affecting the knee or another large joint, which develops an effusion over 12 to 24 hours with only mild to moderate pain and minimal signs of inflammation. Attacks last three to five days and may parallel menses in females. Systemic symptoms are absent, and no joint damage occurs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-329967/","orphanet_url":"https://www.orpha.net/en/disease/detail/329967","names":{"fr":{"name":"Hydarthrose intermittente","definition":"Maladie rhumatologique rare caractérisée par des épisodes récurrents et à rémission spontanée d'arthrite monoarticulaire aiguë, survenant souvent à des intervalles réguliers, touchant typiquement le genou ou une autre grande articulation, à l'origine d'un épanchement en 12 à 24 heures, accompagnée uniquement d'une douleur légère à modérée et de légers signes d'inflammation. Les crises durent de trois à cinq jours et peuvent être concomitantes avec les menstruations chez les femmes. On n'observe pas de symptômes systémiques ni de lésions articulaires."},"de":{"name":"Hydarthrose, intermittierende","definition":"Eine seltene rheumatologische Erkrankung, die durch wiederkehrende, schubweise auftretende akute monoartikuläre Arthritis gekennzeichnet ist. Sie tritt häufig mit einer gewissen Periodizität auf und betrifft typischerweise das Knie oder ein anderes großes Gelenk, wobei sich innerhalb von 12 bis 24 Stunden ein Erguss mit leichten bis mäßigen Schmerzen und minimalen Entzündungszeichen entwickelt. Die Schübe dauern drei bis fünf Tage und können bei Frauen zeitgleich mit der Menstruation auftreten. Es gibt keine systemischen Symptome und keine Gelenkschäden."},"es":{"name":"Hidrartrosis intermitente","definition":"Es una enfermedad reumatológica poco frecuente caracterizada por episodios recurrentes y autolimitados de artritis monoarticular aguda, a menudo con una periodicidad fija, que suele afectar a la rodilla u otras grandes articulaciones. Se manifiesta con un derrame de 12 a 24 horas de duración acompañado de dolor de leve a moderado y signos mínimos de inflamación. Los ataques duran de tres a cinco días y pueden ser coincidentes con la menstruación en las mujeres. Los síntomas sistémicos están ausentes y no se produce daño articular."},"it":{"name":"Idrartrosi intermittente","definition":"Si tratta di una malattia reumatica rara, caratterizzata da episodi ricorrenti autolimitanti di artrite monoarticolare acuta, che si manifesta ad intervalli regolari, e che di solito interessa il ginocchio o un'altra grande articolazione. In genere nell'arco di 12-24 ore si sviluppa un versamento associato a dolore lieve-moderato e a minima infiammazione. Gli episodi durano tre-cinque giorni e possono coincidere con le mestruazioni nelle femmine. I pazienti non presentano sintomi sistemici o danni articolari."},"nl":{"name":"Intermitterende hydrartrose","definition":"Een zeldzame reumatologische aandoening, gekarakteriseerd door recidiverende, remitterende episodes van acute monoarticulaire artritis, vaak met vaste periodiciteit, die doorgaans knie of een ander groot gewricht aantast en gedurende 12 tot 24 uur effusie ontwikkelt met enkel milde tot matige pijn en minimale verschijnselen van inflammatie. Aanvallen duren drie tot vijf dagen en lopen mogelijk parallel met menstruatie bij vrouwen. Systemische symptomen zijn afwezig, en er treedt geen beschadiging van gewricht op."},"pt":{"name":"Hidrartrose intermitente"},"pl":{"name":"Nawracające wysiękowe zapalenie stawu"},"cs":{"name":"Intermitentní hydrartróza"},"uk":{"name":"Інтермітуючий гідроартроз","definition":"A rare rheumatologic disease characterized by recurrent self-remitting episodes of acute monoarticular arthritis, often with a fixed periodicity, typically affecting the knee or another large joint, which develops an effusion over 12 to 24 hours with only mild to moderate pain and minimal signs of inflammation. Attacks last three to five days and may parallel menses in females. Systemic symptoms are absent, and no joint damage occurs."},"zh":{"name":"间歇性关节炎","definition":"一种罕见的风湿病，以急性单关节关节炎反复发作为特征，往往有固定的周期性，通常影响膝关节或另一大关节，在12至24小时内形成渗出液，只有轻度到中度疼痛和轻微的炎症症状。发作持续3到5天，可能与女性月经周期伴行。无全身症状，无关节损伤。"},"tr":{"name":"İntermittent hidrartroz"}},"xrefs":[{"source":"ICD-10","code":"M12.4","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"FA27.4","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1855039383"},{"source":"MONDO","code":"0018015","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0149910","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":271870,"name":"Rare genetic systemic or rheumatologic disease","classifications":[156]},{"orpha":486955,"name":"Rare pediatric rheumatologic disease","classifications":[231]},{"orpha":182231,"name":"Rare rheumatologic disease","classifications":[196]}],"children":[],"genes":[{"symbol":"MEFV","name":"MEFV innate immunity regulator, pyrin","gene_type":"gene with protein product","association":"Candidate gene tested in","status":"Not yet assessed","source":"16802374[PMID]","hgnc":"6998","ensembl":"ENSG00000103313","omim":"608107","loci":["16p13.3"]},{"symbol":"TNFRSF1A","name":"TNF receptor superfamily member 1A","gene_type":"gene with protein product","association":"Candidate gene tested in","status":"Not yet assessed","source":"22887853[PMID]","hgnc":"11916","ensembl":"ENSG00000067182","omim":"191190","loci":["12p13.31"]}],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-05-05","source":"15454124[PMID]_16802374[PMID]_17889261[PMID]","terms":[{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002815","label":"Abnormality of the knee","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0045086","label":"Knee joint hypermobility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000934","label":"Chondrocalcinosis","frequency":"Very rare (<4-1%)","criteria":null}]}}