{"orpha":329883,"name":"Non-hypoproteinemic hypertrophic gastropathy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Hypertrophic gastropathy without hypoproteinemia"],"definition":"A rare gastroesophageal disease characterized by diffusely enlarged gastric folds, excessive mucus secretion, normal serum protein and gastric TGF-alpha levels. Patients typically present anemia, abdominal pain not related to eating or bowel habits and absence of peripheral edema.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-329883/","orphanet_url":"https://www.orpha.net/en/disease/detail/329883","names":{"fr":{"name":"Gastropathie hypertrophique sans hypoprotéinémie","synonyms":["Gastrite hypertrophique sans perte de protéines"],"definition":"Maladie gastro-oesophagienne rare caractérisée par une hypertrophie diffuse des plis gastriques, une sécrétion excessive de mucus, un taux normal de protéines sériques et de TGF-alpha gastrique. Les patients présentent généralement une anémie, des douleurs abdominales sans lien avec l'ingestion de nourriture ou le transit intestinal, en l'absence d'oedème périphérique."},"de":{"name":"Hypertrophe Gastropathie, nicht-hypoproteinämische","synonyms":["Hypertrophe Gastropathie ohne Hypoproteinämie"]},"es":{"name":"Gastropatía hipertrófica no hipoproteinémica","synonyms":["Gastropatía hipertrófica sin hipoproteinemia"],"definition":"La gastropatía hipertrófica no hipoproteinémica es una enfermedad gastroesofágica poco frecuente caracterizada por pliegues gástricos agrandados de forma difusa, exceso de secreción de moco , niveles normales de proteína sérica y de TGF-alfa gástrico. Los afectados suelen presentar anemia, dolor abdominal no relacionado con la alimentación o con los hábitos intestinales y ausencia de edema periférico."},"it":{"name":"Gastropatia ipertrofica non ipoproteinemica","synonyms":["Gastropatia ipertrofica senza ipoproteinemia"],"definition":"La gastropatia ipertrofica non ipoproteinemica è una malattia gastroesofagea rara, caratterizzata da ampia plicatura gastrica, ipersecrezione di muco e livelli normali di proteine e TGF-alfa gastrico nel siero. Di solito i pazienti presentano anemia e dolore addominale non correlato alle abitudini alimentari o intestinali, in assenza di edema periferico."},"nl":{"name":"Niet-hypoproteïnemische hypertrofische gastropathie","synonyms":["Hypertrofische gastropathie zonder hypoproteïnemie"],"definition":"Niet-hypoproteïnemische hypertrofische gastropathie is een zeldzame gastro-oesofageale ziekte die gekarakteriseerd wordt door diffuus vergrote maagplooien, overmatige secretie van mucus, normale gehaltes van eiwitten in het serum en van TGF-alfa in de maag. Patiënten presenteren zich doorgaans met anemie, buikpijn niet gerelateerd aan eetgewoonten of stoelgang, en afwezigheid van perifeer oedeem."},"pt":{"name":"Gastropatia hipertrófica não hipoproteinémica"},"pl":{"name":"Gastropatia przerostowa bez hipoproteinemii","synonyms":["Gastropatia przerostowa bez hipoproteinemii"],"definition":"*Gastropatia przerostowa bez hipoproteinemii jest rzadką chorobą żołądka i przełyku, która charakteryzuje się obecnością rozlanych, powiększonych fałdów żołądkowych, nadmiernym wydzielaniem śluzu, prawidłowym stężeniem białka w surowicy oraz stężeniem TGF-alfa w żołądku. Zwykle występuje niedokrwistość, ból brzucha niezwiązany z posiłkiem lub wypróżnieniem oraz brak obrzęków obwodowych."},"cs":{"name":"Non-hypoproteinemická hypertrofická gastropatie","synonyms":["Hypertrofická gastropatie bez hypoproteinemie"]},"uk":{"name":"Негіпопротеїнемічна гіпертрофічна гастропатія","synonyms":["Гіпертрофічна гастропатія без гіпопротеїнемії"],"definition":"A rare gastroesophageal disease characterized by diffusely enlarged gastric folds, excessive mucus secretion, normal serum protein and gastric TGF-alpha levels. Patients typically present anemia, abdominal pain not related to eating or bowel habits and absence of peripheral edema."},"zh":{"name":"非低蛋白性肥厚性胃病","synonyms":["肥厚性胃病不伴低蛋白血症"],"definition":"非低蛋白血症性肥厚性胃病是一种少见的胃食管疾病，其特征是胃皱襞扩张，粘液分泌过多，血清蛋白和胃TGF-α水平正常。患者通常表现为贫血，与饮食或肠道习惯无关的腹痛，无外周水肿。"},"tr":{"name":"Hipoproteinemik olmayan hipertrofik gastropati","synonyms":["Hipoproteinemi ile seyretmeyen hipertrofik gastropati"]}},"xrefs":[{"source":"ICD-10","code":"K29.6","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DA42.76","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018009","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4750834","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":101936,"name":"Rare gastroesophageal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Autosomal dominant"],"onset":["No data available"],"prevalence":[{"type":"Cases/families","qualification":"Family(ies)","class":null,"value":1.0,"area":"Worldwide","status":"Validated","source":"22711003[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}