{"orpha":324648,"name":"Invasive non-typhoidal salmonellosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Invasive non-typhoidal salmonella disease","iNTS disease"],"definition":"Invasive non-typhoidal salmonellosis is a rare, bacterial, infectious disease caused by extraintestinal infection of non-typhoidal serotypes of <i> Salmonella enterica </i> in patients with underlying HIV infection, malaria or malignancy. It has a high mortality rate and patients typically present with fever, pallor and respiratory signs (cough, tachypnea, pneumonia). Gastrointestinal manifestations (diarrhea, vomit, abdominal pain) are not common. Occasionally, organ abscesses, septic shock and meningitis may be observed.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-324648/","orphanet_url":"https://www.orpha.net/en/disease/detail/324648","names":{"fr":{"name":"Salmonellose non typhique invasive","definition":"La salmonellose non typhique invasive est une maladie infectieuse bactérienne rare causée par l'infection extra-intestinale de sérotypes non typhiques de <i>Salmonella enterica</i> chez des patients atteints d'une infection par le VIH, du paludisme ou d'une malignité sous-jacents. Son taux de mortalité est élevé et les patients présentent habituellement une fièvre, une pâleur et des signes respiratoires (toux, tachypnée, pneumonie). Les manifestations gastro-intestinales (diarrhée, vomissements, douleur abdominale) sont rares. Occasionnellement, des abcès au niveau d'un organe, un choc septique et une méningite peuvent s'observer."},"de":{"name":"Salmonellose, invasive, nicht-typhoide","synonyms":["Salmonellen-Krankheit, invasive nicht-typhoidale","iNTS-Krankheit"],"definition":"Die invasive nicht-typhoide Salmonellose ist eine seltene, bakterielle Infektionskrankheit, die durch eine extraintestinale Infektion mit nicht-typhoiden Serotypen von <i> Salmonella enterica </i> bei Patienten mit zugrunde liegender HIV-Infektion, Malaria oder Malignität verursacht wird. Sie hat eine hohe Sterblichkeitsrate und die Patienten präsentieren sich typischerweise mit Fieber, Blässe und respiratorischen Zeichen (Husten, Tachypnoe, Pneumonie). Gastrointestinale Manifestationen (Durchfall, Erbrechen, abdominale Schmerzen) sind nicht häufig. Gelegentlich können Organabszesse, septischer Schock und Meningitis beobachtet werden."},"es":{"name":"Salmonelosis invasiva no tifoidea","synonyms":["Enfermedad de invasiva por salmonella no tifoidea","Enfermedad invasiva por SNT"],"definition":"La salmonelosis no-tifoidea invasiva es una enfermedad infecciosa bacteriana poco frecuente causada por la infección extraintestinal por serotipos no-tifoideos de <i> Salmonella enterica </ i> en pacientes con infección subyacente por VIH, malaria o patología maligna. Tiene una elevada tasa de mortalidad y, por lo general, los afectados presentan fiebre, palidez y signos respiratorios (tos, taquipnea, neumonía). Las manifestaciones gastrointestinales (diarrea, vómito, dolor abdominal) son poco comunes. Ocasionalmente, se pueden observar abscesos en órganos, choque séptico y meningitis."},"it":{"name":"Salmonellosi non tifoide invasiva","definition":"La salmonellosi non tifoide invasiva è una malattia infettiva rara di origine batterica, causata dall'infezione extraintestinale da sierotipi non tifoidei di Salmonella enterica in pazienti con precedente infezione da HIV, malaria o con tumori maligni. Il tasso di mortalità è alto e di solito i pazienti presentano febbre, pallore e sintomi respiratori (tosse, tachipnea e polmonite). I segni gastrointestinali (diarrea, vomito, dolore addominale) sono rari. Sono stati descritti raramente ascessi negli organi, shock settico e meningite."},"nl":{"name":"Invasieve niet-tyfoïde salmonellose","synonyms":["Invasieve niet-tyfoïde salmonella-infectie","iNTS-ziekte"],"definition":"Invasieve niet-tyfeuze salmonellose is een zeldzame, bacteriële, infectueuze ziekte die veroorzaakt wordt door extra-intestinale infectie met niet-tyfeuze serotypes van <i>Salmonella enterica</i> in patiënten met onderliggende HIV-infectie, malaria of maligniteit. Het vertoont een hoog sterftecijfer en patiënten vertonen doorgaans koorts, bleekheid en respiratoire tekenen (hoest, tachypnoe, pneumonie). Gastro-intestinale manifestaties (diarree, braken, buikpijn) komen niet veel voor. Soms kunnen orgaanabcessen, septische shock en meningitis geobserveerd worden."},"pt":{"name":"Salmonelose não-tifoide invasiva"},"pl":{"name":"Inwazyjna salmonelloza nietyfusowa","synonyms":["Invasive non-typhoidal salmonella disease","iNTS disease"]},"cs":{"name":"Invazivní netyfoidní salmonelóza","synonyms":["Invasive non-typhoidal salmonella disease","iNTS disease"]},"uk":{"name":"Інвазивний нетифозний сальмонельоз","synonyms":["Хвороба iNTS","Інвазивні нетифозні сальмонельозні захворювання"],"definition":"Invasive non-typhoidal salmonellosis is a rare, bacterial, infectious disease caused by extraintestinal infection of non-typhoidal serotypes of <i> Salmonella enterica </i> in patients with underlying HIV infection, malaria or malignancy. It has a high mortality rate and patients typically present with fever, pallor and respiratory signs (cough, tachypnea, pneumonia). Gastrointestinal manifestations (diarrhea, vomit, abdominal pain) are not common. Occasionally, organ abscesses, septic shock and meningitis may be observed."},"zh":{"name":"侵袭性非伤寒沙门氏菌病","synonyms":["iNTS病"],"definition":"侵袭性非伤寒沙门氏菌病是一种罕见的细菌性传染病，见于感染HIV、疟疾或恶性肿瘤患者的肠道外感染。死亡率高，病人通常表现为发热、苍白和呼吸症状（咳嗽、呼吸急促、肺炎）。胃肠道症状（腹泻、呕吐、腹痛）并不常见。偶尔可观察到器官脓肿、败血症性休克和脑膜炎。"},"tr":{"name":"İnvazif non-tifoid salmonelloz","synonyms":["iNTS hastalığı","İnvazif tifoidal olmayan salmonella hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A02.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1A09.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017944","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4706572","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":795,"name":"Rare form of salmonellosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}