{"orpha":319251,"name":"Rift valley fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-319251/","orphanet_url":"https://www.orpha.net/en/disease/detail/319251","names":{"fr":{"name":"Fièvre de la vallée du Rift","definition":"Maladie causée par le virus de la fièvre de la vallée du Rift (VFVR), un arbovirus, caractérisée par une maladie fébrile généralement spontanément résolutive, mais qui, dans certains cas, peut également se manifester par une thrombose, une baisse de la vision, des hémorragies et/ou des symptômes neurologiques."},"de":{"name":"Rift-Valley-Fieber"},"es":{"name":"Fiebre del valle del Rift","definition":"La fiebre del Valle del Rift (FVR), causada por el virus de la fiebre del Valle del Rift (un arbovirus) está caracterizada por una enfermedad febril generalmente autolimitada pero que en algunos casos también puede manifestarse con trombosis, pérdida de visión, hemorragias y/o síntomas neurológicos."},"it":{"name":"Febbre della Rift Valley"},"nl":{"name":"Rift Valley-koorts","definition":"Rift Valley-koorts (RVS), veroorzaakt door Rift Valley-koortsvirus (RVFV), een arbovirus, wordt gekenmerkt door een gewoonlijk zelfbeperkende febriele ziekte maar kan zich in sommige gevallen manifesteren met trombose, verlies van gezichtsvermogen, bloedingen en/of neurologische symptomen."},"pt":{"name":"Febre do vale Rift"},"pl":{"name":"Gorączka doliny Rift"},"cs":{"name":"Horečka údolí Rift"},"uk":{"name":"Лихоманка Рифтової долини","definition":"Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms."},"zh":{"name":"裂谷热","definition":"裂谷热（RVF）由裂谷热病毒（RVFV）引起，是一种虫媒病毒，其特征是通常具有自限性的发热性疾病，但在某些情况下也可表现为血栓形成、视力丧失、出血和/或神经系统症状。"},"tr":{"name":"Rift vadisi ateşi"}},"xrefs":[{"source":"ICD-10","code":"A92.4","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D44","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"854137188"},{"source":"MONDO","code":"0017880","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012295","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0035613","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039143","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-09-10","source":"32816810[PMID]_31310198[PMID]_28457351[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003237","label":"Increased circulating IgG level","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000478","label":"Abnormality of the eye","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032323","label":"Periodic fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007663","label":"Reduced visual acuity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000573","label":"Retinal hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025188","label":"Retinal vasculitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032118","label":"Retinitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000575","label":"Scotoma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001977","label":"Abnormal thrombosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012229","label":"CSF pleocytosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025013","label":"Decerebrate rigidity","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003781","label":"Excessive salivation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000225","label":"Gingival bleeding","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002248","label":"Hematemesis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001269","label":"Hemiparesis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0040049","label":"Macular edema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002249","label":"Melena","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002385","label":"Paraparesis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005542","label":"Prolonged whole-blood clotting time","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031691","label":"Severe viral infection","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002321","label":"Vertigo","frequency":"Very rare (<4-1%)","criteria":null}]}}