{"orpha":319247,"name":"Hantavirus pulmonary syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare viral hemorrhagic fever characterized by virus-induced microvascular leakage rapidly leading to a severe illness with diffuse pulmonary edema and respiratory failure. These symptoms set in after a short first disease stage with fever, myalgia, and headache, followed by severe gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. The high lethality of the disease is due to the possible development of hypotension and cardiogenic shock.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-319247/","orphanet_url":"https://www.orpha.net/en/disease/detail/319247","names":{"fr":{"name":"Syndrome pulmonaire à Hantavirus","synonyms":["SPH"],"definition":"Fièvre hémorragique virale rare caractérisée par une perméabilité microvasculaire induite par le virus, progressant rapidement vers une maladie grave avec oedème pulmonaire diffus et insuffisance respiratoire. Ces symptômes apparaissant à la suite d'une courte première phase de la maladie accompagnée d'une fièvre, de myalgies et de céphalées, sont suivis de symptômes gastro-intestinaux sévères, à savoir douleurs abdominales, vomissements et diarrhées. Le risque de développer une hypotension et le choc cardiogénique qui s'ensuit sont la principale raison du taux élevé de décès dus à la maladie."},"de":{"name":"Hantavirus-induziertes pulmonales Syndrom","synonyms":["HPS","Hantavirus-Lungensyndrom","Hantavirus-induziertes kardiopulmonales Syndrom"],"definition":"Ein seltene Infektionskrankheit aus der Gruppe der viralen hämorrhagischen Fieber, die durch eine virusinduzierte mikrovaskuläre Leckage gekennzeichnet ist und rasch zu einer schweren Erkrankung mit diffusem Lungenödem und Atemstillstand führt. Diese Symptome treten nach einem kurzen ersten Krankheitsstadium mit Fieber, Myalgie und Kopfschmerzen auf, gefolgt von schweren gastrointestinalen Symptomen wie Bauchschmerzen, Erbrechen und Durchfall. Die hohe Letalität der Erkrankung ist auf die mögliche Entwicklung einer Hypotonie und eines kardiogenen Schocks zurückzuführen."},"es":{"name":"Síndrome pulmonar por hantavirus","definition":"Es una fiebre hemorrágica viral poco frecuente caracterizada por un aumento de la permeabilidad capilar inducida por virus que progresa rápidamente a una enfermedad grave con edema pulmonar difuso e insuficiencia respiratoria. Estos síntomas aparecen después de una breve etapa de la enfermedad caracterizada por fiebre, mialgia y cefalea seguidos de síntomas gastrointestinales graves tales como dolor abdominal, vómitos y diarrea. La alta letalidad de la enfermedad se debe al posible desarrollo de hipotensión y shock cardiogénico."},"it":{"name":"Sindrome polmonare da hantavirus","definition":"Si tratta di una febbre emorragica virale rara, caratterizzata da un aumento della permeabilità microvascolare indotto dal virus, che esita rapidamente in una malattia grave caratterizzata da edema polmonare diffuso e insufficienza respiratoria. Questi sintomi insorgono dopo un breve stadio inziale caratterizzato da febbre, mialgia e cefalea, seguiti da sintomi gastrointestinali gravi (dolore addominale, vomito e diarrea). L'elevata mortalità della malattia dipende dalla possibile insorgenza di ipotensione e shock cardiogeno."},"nl":{"name":"Pulmonaal syndroom door hantavirus","definition":"Een zeldzame, virale hemorragische koorts, gekarakteriseerd door virus-geïnduceerde microvasculaire lekkage die snel leidt tot een ernstige ziekte met diffuus longoedeem en respiratoir falen. Deze symptomen beginnen na een kort eerste stadium van de ziekte met koorts, myalgie en hoofdpijn, gevolgd door ernstige gastro-intestinale symptomen zoals abdominale pijn, braken, en diarree. De hoge letaliteit van de ziekte is te wijten aan mogelijke ontwikkeling van hypotensie en cardiogene shock."},"pt":{"name":"Síndrome pulmonar por hantavirus"},"pl":{"name":"Hantawirusowy zespół płucny"},"cs":{"name":"Hantavirový plicní syndrom"},"uk":{"name":"Хантавірусний легеневий синдром","definition":"A rare viral hemorrhagic fever characterized by virus-induced microvascular leakage rapidly leading to a severe illness with diffuse pulmonary edema and respiratory failure. These symptoms set in after a short first disease stage with fever, myalgia, and headache, followed by severe gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. The high lethality of the disease is due to the possible development of hypotension and cardiogenic shock."},"zh":{"name":"汉坦病毒肺综合征","definition":"一种罕见的病毒性出血热，特征是病毒引起的微血管渗漏，迅速导致严重疾病，伴有弥漫性肺水肿和呼吸衰竭。短暂的疾病初始阶段后，出现发热、肌痛和头痛，随后出现严重的胃肠道症状，如腹痛、呕吐和腹泻。可能发生低血压和心源性休克，是导致高致死率的原因。"},"tr":{"name":"Hantavirüs pulmoner sendromu"}},"xrefs":[{"source":"ICD-10","code":"B33.4+","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"J17.1*","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"1D62.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"582624609"},{"source":"MONDO","code":"0017879","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D018804","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0243025","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"69","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10019143","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}