{"orpha":31828,"name":"Digitalis poisoning","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, potentially life-threatening poisoning that provokes conduction disturbances, characterized by increased automaticity and decreased conduction. Acute poisoning presents with the common initial manifestations of nausea and vomiting, cardiovascular manifestations (bradycardia, heart block and a variety of dysrhythmias), central nervous system manifestations (lethargy, confusion and weakness) and hyperkalemia. Chronic poisoning is more insidious, manifesting with gastrointestinal symptoms, altered mental status, and visual disturbances.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-31828/","orphanet_url":"https://www.orpha.net/en/disease/detail/31828","names":{"fr":{"name":"Intoxication par les digitaliques","synonyms":["Intoxication digitalique"],"definition":"Intoxication rare, potentiellement létale, à l'origine de troubles de la conduction cardiaque, caractérisée par une augmentation de l'automatisme cardiaque et par une diminution de la conduction cardiaque. Les manifestations initiales les plus fréquentes d'une intoxication aiguë sont nausées et vomissements, manifestations cardiovasculaires (bradycardie, bloc cardiaque, diverses dysrythmies), signes d'atteinte du système nerveux central (léthargie, confusion, faiblesse) et hyperkaliémie. Les manifestations d'une intoxication chronique sont plus insidieuses, à type de symptômes gastro-intestinaux, d'altération de l'état mental et de troubles de la vision."},"de":{"name":"Digitalis-Vergiftung","definition":"Eine potentiell lebensbedrohliche Vergiftung, die Leitungsstörungen hervorruft, die durch erhöhte Automatismen und verminderte Leitfähigkeit gekennzeichnet sind. Eine akute Vergiftung manifestiert sich initial mit Übelkeit und Erbrechen, kardiovaskulären Manifestationen (Bradykardie, Herzblock und Dysrhythmien), Manifestationen des Zentralnervensystems (Lethargie, Verwirrtheit und Schwäche) und Hyperkaliämie. Eine chronische Vergiftung ist heimtückischer und manifestiert sich mit gastrointestinalen Symptomen, verändertem Geisteszustand und Sehstörungen."},"es":{"name":"Intoxicación digitálica","definition":"Es una intoxicación potencialmente mortal que provoca defectos en la conducción caracterizados por un incremento de la automaticidad y una disminución de la conducción. La intoxicación aguda se presenta con los síntomas iniciales comunes de nauseas y vómitos, manifestaciones cardiovasculares (bradicardia, bloqueo cardiaco y una variedad de disritmias), del sistema nervioso central (letargia, confusión y debilidad) e hiperpotasemia. La intoxicación crónica es más insidiosa, manifestándose con síntomas gastrointestinales, alteración del estado mental, y trastornos visuales."},"it":{"name":"Intossicazione da digitale","definition":"L'intossicazione da digitale (digossina) è un avvelenamento potenzialmente letale che provoca disturbi della conduzione, caratterizzati da un aumento dell'automaticità e una diminuzione della conduzione. L'avvelenamento acuto esordisce con sintomi comuni come la nausea, il vomito, segni sintomi (bradicardia, blocco cardiaco, disritmie), a carico del sistema nervoso centrale (letargia, stato confusionale e debolezza) e iperkaliemia. L'avvelenamento cronico è più insidioso ed esordisce con sintomi gastrointestinali, alterazioni dello stato mentale e disturbi della vista."},"nl":{"name":"Digitalisvergiftiging","definition":"Een zeldzame, potentieel levensbedreigende vergiftiging die geleidingsstoornissen uitlokt, gekenmerkt door toename van automaticiteit en afname van geleiding. Acute vergiftiging presenteert zich met de gangbare initiële manifestaties misselijkheid en braken, cardiovasculaire manifestaties (bradycardie, hartblok en verschillende hartritmestoornissen), manifestaties van centraal zenuwstelsel (lethargie, verwardheid en zwakheid), en hyperkaliëmie. Chronische vergiftiging is meer sluipend en manifesteert zich met gastro-intestinale symptomen, gewijzigde mentale toestand, en visuele stoornissen."},"pt":{"name":"Intoxicação por digitálicos"},"pl":{"name":"Zatrucie naparstnicą","definition":"Rzadkie, potencjalnie zagrażające życiu zatrucie wywołujące zaburzenia przewodnictwa w sercu, charakteryzujące się zwiększonym automatyzmem i zmniejszonym przewodnictwem. Ostre zatrucie objawia się początkowo nudnościami i wymiotami, objawami sercowo-naczyniowymi (bradykardia, blok serca i różne zaburzenia rytmu), objawami ze strony ośrodkowego układu nerwowego (senność, dezorientacja i osłabienie) oraz hiperkaliemią. Zatrucie przewlekłe jest bardziej podstępne, mogą wystąpić objawy żołądkowo-jelitowe, zaburzenia psychiczne oraz zaburzenia widzenia."},"cs":{"name":"Otrava digitalisem"},"uk":{"name":"Отруєння наперстянкою","definition":"A rare, potentially life-threatening poisoning that provokes conduction disturbances, characterized by increased automaticity and decreased conduction. Acute poisoning presents with the common initial manifestations of nausea and vomiting, cardiovascular manifestations (bradycardia, heart block and a variety of dysrhythmias), central nervous system manifestations (lethargy, confusion and weakness) and hyperkalemia. Chronic poisoning is more insidious, manifesting with gastrointestinal symptoms, altered mental status, and visual disturbances."},"zh":{"name":"洋地黄中毒"},"tr":{"name":"Digitalis zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T46.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"NE60","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017863","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0274726","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":306640,"name":"Rare intoxication due to medical products","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}