{"orpha":31827,"name":"Paraquat poisoning","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare intoxication with paraquat (a non-selective bipyridilium herbicide that has been banned in Europe), usually occurring through ingestion of the poison, and that presents with caustic injury of the oral cavity and pharynx, as well as nausea, vomiting, epigastric pain, lethargy, loss of consciousness and fever. Patients may develop potentially life-threatening complications such as hepatic dysfunction, acute tubular necrosis and renal insufficiency, and respiratory failure (due to pulmonary fibrosis) due to its inherent toxicity and lack of effective treatment. Intoxication via inhalation, injection and dermal or mucus contact have also been reported.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-31827/","orphanet_url":"https://www.orpha.net/en/disease/detail/31827","names":{"fr":{"name":"Intoxication par le paraquat","definition":"Intoxication rare par le paraquat (un herbicide bipyridinium non sélectif qui a été interdit en Europe), généralement par ingestion du poison, qui se manifeste par des lésions caustiques de la cavité buccale et du pharynx, ainsi que par des nausées, des vomissements, des douleurs épigastriques, une léthargie, une perte de conscience et une fièvre. En raison de sa toxicité inhérente et de l'absence de traitement efficace, les patients peuvent développer des complications potentiellement létales, telles qu'une insuffisance hépatique, une nécrose tubulaire aiguë, une insuffisance rénale, ainsi qu'une insuffisance respiratoire (due à une fibrose pulmonaire). Des cas d'intoxication par inhalation, injection et contact avec la peau ou le mucus ont également été rapportés."},"de":{"name":"Paraquat-Vergiftung","definition":"Paraquat-Vergiftung ist eine seltene Vergiftung mit Paraquat (einem nicht-selektiven Bipyridilium-Herbizid, das in Europa verboten ist), das normalerweise durch orale Aufnahme des Giftes auftritt. Es kommt zu ätzenden Verletzungen der Mundhöhle und des Rachens sowie zu Übelkeit und Erbrechen, Oberbauchschmerzen, Lethargie, Bewusstlosigkeit und Fieber. Patienten können möglicherweise lebensbedrohliche Komplikationen wie Leberfunktionsstörung, akute tubuläre Nekrose und Niereninsuffizienz und respiratorische Insuffizienz (aufgrund von Lungenfibrose) aufgrund ihrer inhärenten Toxizität und des Fehlens einer wirksamen Behandlung entwickeln. Intoxikationen über Inhalation, Injektion und Haut- oder Schleimkontakt wurden ebenfalls berichtet."},"es":{"name":"Intoxicación por paraquat","definition":"Es una intoxicación poco común con paraquat (un herbicida bipiridilo no selectivo prohibido en Europa) que, por lo habitual, se produce por ingesta del veneno y que se presenta con lesión caústica de la cavidad oral y la faringe, así como con nauseas, vómitos, dolor epigástrico, letargia, pérdida de la consciencia y fiebre. Los afectados pueden desarrollar complicaciones potencialmente letales, tales como disfunción hepática, necrosis tubular aguda e insuficiencia renal e insuficiencia respiratoria (por fibrosis pulmonar) debido a su toxicidad inherente y a la falta de un tratamiento efectivo. También se ha descrito intoxicación vía inhalación, inyección y contacto dérmico o a través de las mucosas."},"it":{"name":"Intossicazione da Paraquat","definition":"L'intossicazione da Paraquat (un diserbante non selettivo a base di bipiridile, vietato in Europa) è rara e di solito si verifica a seguito dell'ingestione della sostanza; si manifesta con una lesione caustica del cavo orale e della faringe, accompagnata da nausea, vomito, dolore epigastrico, letargia, perdita di coscienza e febbre. I pazienti possono sviluppare complicanze potenzialmente letali, come la disfunzione epatica, la necrosi tubulare acuta, l'insufficienza renale e l'insufficienza respiratoria (causata dalla fibrosi polmonare) secondarie alla tossicità del Paraquat e all'assenza di un trattamento efficace. Sono stati descritti anche casi di intossicazione da inalazione, iniezione e contatto attraverso la cute o il muco."},"nl":{"name":"Paraquatvergiftiging","definition":"Paraquatvergiftiging is een zeldzame intoxicatie met paraquat (een niet-selectief bipyridine-herbicide dat verboden is in Europa) die meestal ontstaat door inname van het gif, en die zich manifesteert met caustische letsels in de mondholte en farynx, alsook misselijkheid, braken, epigastrische pijn, lethargie, bewusteloosheid en koorts. Patiënten kunnen potentieel levensbedreigende complicaties ontwikkelen, zoals leverdisfunctie, acute tubulaire necrose en nierinsufficiëntie, en respiratoir falen (vanwege pulmonale fibrose), als gevolg van de inherente toxiciteit van deze stof en het gebrek aan een effectieve behandeling. Intoxicatie door inhalatie, injectie en contact met de huid of het slijmvlies werden ook reeds gerapporteerd."},"pt":{"name":"Intoxicação por paraquato"},"pl":{"name":"Zatrucie parakwatem"},"cs":{"name":"Otrava paraquatem"},"uk":{"name":"Отруєння паракватом","definition":"A rare intoxication with paraquat (a non-selective bipyridilium herbicide that has been banned in Europe), usually occurring through ingestion of the poison, and that presents with caustic injury of the oral cavity and pharynx, as well as nausea, vomiting, epigastric pain, lethargy, loss of consciousness and fever. Patients may develop potentially life-threatening complications such as hepatic dysfunction, acute tubular necrosis and renal insufficiency, and respiratory failure (due to pulmonary fibrosis) due to its inherent toxicity and lack of effective treatment. Intoxication via inhalation, injection and dermal or mucus contact have also been reported."},"zh":{"name":"百草枯中毒"},"tr":{"name":"Parakuat zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T60.3","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1593116762"},{"source":"MONDO","code":"0017862","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0413070","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}