{"orpha":31205,"name":"Rat-bite fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare bacterial zoonosis characterized by fever, arthralgia and a rash predominantly affecting the extremities, typically occurring after a bite or scratch from infected rats. The disease may be caused by <i>Streptobacillus moniliformis</i>, also known as streptobacillosis, or by <i>Spirillum minus</i>, also known as sodoku.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-31205/","orphanet_url":"https://www.orpha.net/en/disease/detail/31205","names":{"fr":{"name":"Fièvre due aux morsures de rat","definition":"Zoonose bactérienne rare caractérisée par une fièvre, des arthralgies et une éruption cutanée touchant principalement les extrémités, survenant généralement à la suite d'une morsure ou d'une griffure d'un rat infecté. La maladie peut être causée par <i>Streptobacillus moniliformis</i>, également connu sous le nom de streptobacillose, ou par <i>Spirillum minus</i>, également connu sous le nom de sodoku."},"de":{"name":"Rattenbiss-Fieber","definition":"Eine seltene bakterielle Zoonose, die durch Fieber, Gelenkschmerzen und einen Hautausschlag gekennzeichnet ist, der vorwiegend die Extremitäten befällt und typischerweise nach einem Biss oder Kratzer durch infizierte Ratten auftritt. Die Krankheit kann durch <i>Streptobacillus moniliformis</i>, auch bekannt als Streptobacillose, oder durch <i>Spirillum minus</i>, auch bekannt als Sodoku, verursacht werden."},"es":{"name":"Fiebre causada por mordeduras de rata","definition":"Es una zoonosis bacteriana poco común caracterizada por fiebre, artralgia y erupción cutánea que afecta principalmente a las extremidades, y que suele aparecer tras una mordedura o arañazo de ratas infectadas. La enfermedad puede estar causada por <i>Streptobacillus moniliformis</i>, conocida en este caso como estreptobacilosis, o por <i>Spirillum minus</i>, conocida como sodoku."},"it":{"name":"Febbre da morso di ratto"},"nl":{"name":"Rattenbeetkoorts","synonyms":["Rattenbeetziekte"],"definition":"Een zeldzame bacteriële zoönose, gekenmerkt door koorts, artralgie en huiduitslag die vooral extremiteiten aantast, en typisch optredend na een beet of krab van een geïnfecteerde rat. De ziekte kan veroorzaakt worden door <i>Streptobacillus moniliformis</i>, en is dan ook gekend als streptobacillose, of door <i>Spirillum minus</i>, in welk geval de ziekte ook gekend is als sodoku."},"pt":{"name":"Febre por mordedura de rato","definition":"A febre da mordedura da ratazana (RBF) é uma zoonose bacteriana sistémica que ocorre em indivíduos que foram mordidos ou arranhados por ratazanas infectadas por <i>Streptobacillus moniliformis</i> ou <i>Spirillum minus</i> e caracterizada por febre alta, um exantema nas extremidades e artralgia."},"pl":{"name":"Gorączka od ugryzienia szczura"},"cs":{"name":"Horečka z krysího kousnutí"},"uk":{"name":"Лихоманка від укусу щура","definition":"Rat-bite fever (RBF) is a systemic bacterial zoonosis occurring in individuals that have been bitten or scratched by <i>Streptobacillus moniliformis</i> or <i>Spirillum minus</i>-infected rats and characterized by high fever, a rash on the extremities, and arthralgia."},"zh":{"name":"鼠咬热"},"tr":{"name":"Sıçan humması ateşi"}},"xrefs":[{"source":"ICD-10","code":"A25.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A25.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A25.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B90","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1026551291"},{"source":"MONDO","code":"0006941","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D011906","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0034686","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9557","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10037904","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[{"orpha":99903,"name":"Spirillary rat-bite fever","type":"Etiological subtype"},{"orpha":99905,"name":"Streptobacillary rat-bite fever","type":"Etiological subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-11-19","source":"31015812[PMID]_19008054[PMID]_23529964[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012282","label":"Morbilliform rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002374","label":"Diminished movement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002840","label":"Lymphadenitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040313","label":"Oligoarthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200039","label":"Pustule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025145","label":"Rigors","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040189","label":"Scaling skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003095","label":"Septic arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025181","label":"Abdominal aseptic abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001733","label":"Pancreatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011850","label":"Parotitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025230","label":"Tendonitis","frequency":"Very rare (<4-1%)","criteria":null}]}}