{"orpha":31204,"name":"Nocardiosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare bacterial infection characterized by various clinical manifestations depending on the site of infection, caused by the Gram-positive bacillus <i>Nocardia</i>. The most common presentation is lung infection, which typically follows pathogen inhalation. Dissemination to other organs may occur, especially among immunocompromised patients. Primary skin and soft-tissue infection follows skin inoculation.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-31204/","orphanet_url":"https://www.orpha.net/en/disease/detail/31204","names":{"fr":{"name":"Nocardiose","definition":"Infection bactérienne rare causée par le bacille Gram-positif <i>Nocardia</i>, caractérisée par des signes cliniques qui varient selon le site d'infection. Le tableau clinique le plus courant est une infection pulmonaire, survenant généralement à la suite de l'inhalation d'un agent pathogène. La dissémination à d'autres organes est possible, en particulier chez les patients immunodéprimés. La primo-infection de la peau et des tissus mous fait suite à une inoculation cutanée."},"de":{"name":"Nokardiose","definition":"Eine seltene bakterielle Infektion, die sich je nach Infektionsort durch unterschiedliche klinische Symptome auszeichnet und durch den Gram-positiven Bazillus <i>Nocardia</i> verursacht wird. Am häufigsten tritt eine Lungeninfektion auf, die in der Regel auf eine Inhalation des Erregers folgt. Insbesondere bei immungeschwächten Patienten kann es zu einer Dissemination in andere Organe kommen. Primäre Haut- und Weichteilinfektionen folgen auf die Inokulation der Haut."},"es":{"name":"Nocardiosis","definition":"Es una infección bacteriana poco frecuente caracterizada por diversas manifestaciones clínicas según la localización de la infección, y está causada por el bacilo grampositivo <i>Nocardia</i> spp. La presentación más común es la infección pulmonar, que suele presentarse tras la inhalación del patógeno, pudiendo diseminarse a otros órganos, especialmente en pacientes inmunodeprimidos. La infección primaria de la piel y de las partes blandas se produce tras la inoculación cutánea."},"it":{"name":"Nocardiosi"},"nl":{"name":"Nocardiose","definition":"Een zeldzame bacteriële infectie, gekenmerkt door verschillende klinische manifestaties afhankelijk van de plaats van infectie, veroorzaakt door de Gram-positieve bacillus <i>Nocardia</i>. De meest voorkomende presentatie is longinfectie, die doorgaans volgt na inhalatie van de pathogeen. Er kan verspreiding naar andere organen optreden, vooral bij immuungecompromitteerde patiënten. Primaire infectie van huid en weke delen volgt na binnendringen van de huid."},"pt":{"name":"Nocardiose","definition":"A nocardiose é uma infecção bacteriana local (pele, pulmão, cérebro) ou disseminada (todo o corpo) aguda, subaguda ou crónica."},"pl":{"name":"Nokardioza"},"cs":{"name":"Nokardióza"},"uk":{"name":"Нокардіоз","definition":"Nocardiosis is a local (skin, lung, brain) or disseminated (whole body) acute, subacute, or chronic bacterial infection."},"zh":{"name":"诺卡菌病"},"tr":{"name":"Nokardiyoz"}},"xrefs":[{"source":"ICD-10","code":"A43.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A43.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A43.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A43.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C1B","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"6555116"},{"source":"ICD-11","code":"1C1B.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"101604109"},{"source":"ICD-11","code":"1C1B.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1665504921"},{"source":"ICD-11","code":"1C1B.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017776","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009617","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0028242","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7210","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10029444","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.6,"area":"Canada","status":"Validated","source":"20636427[PMID]_ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-11-19","source":"31363440[PMID]_22469352[PMID]_28626172[PMID]_29146497[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032016","label":"Abnormal sputum","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031864","label":"Bacteremia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031245","label":"Productive cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030049","label":"Brain abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031292","label":"Cutaneous abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000620","label":"Dacryocystitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002097","label":"Emphysema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100523","label":"Liver abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002840","label":"Lymphadenitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030166","label":"Night sweats","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031246","label":"Nonproductive cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002102","label":"Pleuritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032169","label":"Severe infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001482","label":"Subcutaneous nodule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001654","label":"Abnormal heart valve morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0045026","label":"Abnormal mediastinum morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000834","label":"Abnormality of the adrenal glands","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100658","label":"Cellulitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012424","label":"Chorioretinitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000491","label":"Keratitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100532","label":"Scleritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000575","label":"Scotoma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100646","label":"Thyroiditis","frequency":"Very rare (<4-1%)","criteria":null}]}}