{"orpha":306686,"name":"Delayed encephalopathy due to carbon monoxide poisoning","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Delayed encephalopathy due to CO poisoning"],"definition":"A rare neurologic disease characterized by delayed onset of encephalopathy typically within a few weeks after acute carbon monoxide poisoning. The most common symptoms are cognitive impairment, personality changes, and movement disorder including parkinsonism, among others. Prognosis is good with a high rate of spontaneous recovery within a year.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-306686/","orphanet_url":"https://www.orpha.net/en/disease/detail/306686","names":{"fr":{"name":"Syndrome post-intervallaire par intoxication au monoxyde de carbone","definition":"Maladie neurologique rare caractérisée par l'apparition tardive d'une encéphalopathie, généralement quelques semaines après une intoxication aiguë au monoxyde de carbone. Les signes cliniques les plus courants incluent les troubles cognitifs, les changements de personnalité et les troubles du mouvement, dont le parkinsonisme. Le pronostic est bon et le taux de rémissions spontanées au cours de l'année est élevé."},"de":{"name":"Verzögerte Kohlenmonoxidenzephalopathie","synonyms":["Verzögerte Enzephalopathie durch CO-Intoxikation"],"definition":"Eine seltene neurologische Erkrankung, die typischerweise innerhalb weniger Wochen nach einer akuten Kohlenmonoxidvergiftung auftritt und zu einer verzögerten Enzephalopathie führt. Zu den häufigsten Symptomen gehören kognitive Beeinträchtigungen, Persönlichkeitsveränderungen und Bewegungsstörungen, einschließlich Parkinsonismus, unter anderem. Die Prognose ist gut, mit einer hohen Rate an Spontanheilungen innerhalb eines Jahres."},"es":{"name":"Encefalopatía retardada por intoxicación por monóxido de carbono","synonyms":["Encefalopatía retardada por intoxicación por CO"],"definition":"Es una enfermedad neurológica poco frecuente caracterizada por una encefalopatía de inicio tardío, que por lo general debuta unas pocas semanas después de una intoxicación aguda por monóxido de carbono. Los síntomas más frecuentes son afectación cognitiva, cambios de personalidad y trastornos del movimiento, incluyendo parkinsonismo, entre otros. El pronóstico es bueno, con una elevada tasa de remisión espontánea en un año."},"it":{"name":"Encefalopatia tardiva da avvelenamento da monossido di carbonio","synonyms":["Parkinsonismo indotto da CO"],"definition":"Si tratta di una malattia neurologica rara, caratterizzata da un'encefalopatia che esordisce tardivamente, in genere alcune settimane dopo l'avvelenamento acuto da monossido di carbonio. I sintomi più comuni sono il deficit cognitivo, le alterazioni della personalità e i disturbi del movimento, come il parkinsonismo. La prognosi è buona, con un tasso elevato di risoluzione spontanea entro un anno."},"nl":{"name":"Vertraagde encefalopathie door intoxicatie door koolmonoxide","synonyms":["Vertraagde encefalopathie door CO-intoxicatie"],"definition":"Een zeldzame neurologische ziekte, gekarakteriseerd door traag optredende encefalopathie, doorgaans binnen enkele weken na acute vergiftiging door koolmonoxide. De meest gangbare symptomen zijn cognitieve functiestoornis, persoonlijkheidsveranderingen, en bewegingsstoornissen, waaronder parkinsonisme. De prognose is goed, met een hoog percentage van spontaan herstel binnen een jaar."},"pt":{"name":"Encefalopatia tardia induzida pelo monóxido de carbono","synonyms":["Parkinson induzido pelo monóxido de carbono"]},"pl":{"name":"Parkinsonizm indukowany tlenkiem węgla","synonyms":["Parkinsonizm indukowany CO"]},"cs":{"name":"Parkinsonismus indukovaný oxidem uhelnatým","synonyms":["Parkinsonismus indukovaný CO"]},"uk":{"name":"Відстрочена енцефалопатія внаслідок отруєння чадним газом","synonyms":["Відстрочена енцефалопатія внаслідок отруєння СО"],"definition":"A rare neurologic disease characterized by delayed onset of encephalopathy typically within a few weeks after acute carbon monoxide poisoning. The most common symptoms are cognitive impairment, personality changes, and movement disorder including parkinsonism, among others. Prognosis is good with a high rate of spontaneous recovery within a year."},"zh":{"name":"一氧化碳中毒致迟发性脑病","synonyms":["一氧化碳中毒所致迟发性脑病"],"definition":"一种罕见的神经系统疾病，特征是急性一氧化碳中毒后几周内出现迟发性脑病。最常见的症状是认知障碍、人格改变和运动障碍，如帕金森综合征。预后良好，一年内自愈率高。"},"tr":{"name":"Karbon monoksit zehirlenmesine bağlı gecikmiş ensefalopati","synonyms":["CO zehirlenmesine bağlı gecikmiş ensefalopati"]}},"xrefs":[{"source":"ICD-10","code":"G21.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8D43.0Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"468038102"},{"source":"UMLS","code":"C0393565","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]},{"orpha":306679,"name":"Rare parkinsonian syndrome due to intoxication","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2018-03-30","source":"10927805[PMID]","terms":[{"hpo":"HP:0002518","label":"Abnormal periventricular white matter morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012706","label":"Elevated brain choline level by MRS","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002354","label":"Memory impairment","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012708","label":"Reduced brain N-acetyl aspartate level by MRS","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002817","label":"Abnormality of the upper limb","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002067","label":"Bradykinesia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004673","label":"Decreased facial expression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002063","label":"Rigidity","frequency":"Frequent (79-30%)","criteria":null}]}}