{"orpha":300903,"name":"ALK-negative anaplastic large cell lymphoma","type":"Histopathological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["ALK- ALCL","ALK- anaplastic large cell lymphoma"],"definition":"A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-300903/","orphanet_url":"https://www.orpha.net/en/disease/detail/300903","names":{"fr":{"name":"Lymphome anaplasique à grandes cellules ALK négatif","synonyms":["ALCL ALK-","LAGC ALK-","Lymphome anaplasique à grandes cellules ALK-"],"definition":"Le lymphome anaplasique à grandes cellules ALK négatif (LAGC ALK-) est un type de LAGC, un lymphome non hodgkigien des cellules T périphériques, agressif et rare , qui affecte les ganglions lymphatiques et les sites extra-nodaux, sans expression de la protéine kinase lymphome anaplasique (ALK)."},"de":{"name":"Lymphom, anaplastisches großzelliges, ALK-negatives","synonyms":["ALK-ALCL","ALK-anaplastisches großzelliges Lymphom"]},"es":{"name":"Linfoma anaplásico de células grandes ALK-negativo","synonyms":["ALK- ALCL","Linfoma anaplásico de células grandes ALK-"],"definition":"Es un linfoma anaplásico de células grandes (LACG), un linfoma periférico no-Hodgkin de células T poco frecuente y agresivo, que afecta a los ganglios linfáticos y regiones extraganglionares, que se caracteriza por la falta de expresión de una proteína llamada quinasa del linfoma anaplásico (ALK, por sus siglas en inglés)."},"it":{"name":"Linfoma anaplastico a grandi cellule ALK-negativo","synonyms":["ALK- ALCL","Linfoma anaplastico a grandi cellule ALK-"],"definition":"Il linfoma anaplastico a grandi cellule ALK-negativo (ALK- ALCL) è un tipo di ALCL (si veda questo termine), un linfoma periferico non-Hodgkin a cellule T, raro ed aggressivo, che interessa i linfonodi e le sedi extranodali; è caratterizzato dalla mancata espressione della proteina ALK, chinasi del linfoma anaplastico."},"nl":{"name":"ALK-negatief anaplastisch grootcellig lymfoom","synonyms":["ALK anaplastisch grootcellig lymfoom","ALK- ALCL"],"definition":"Een type van ALCL, een zeldzaam en agressief perifeer T-cel non-Hodgkinlymfoom dat lymfeklieren en gebieden buiten de lymfeklieren treft, gekarakteriseerd door het gebrek aan expressie van een proteïne genaamd anaplastisch lymfoomkinase (ALK)."},"pt":{"name":"Linfoma anaplásico de grandes células ALK - negativo"},"pl":{"name":"ALK-negatywny chłoniak anaplastyczny z dużych komórek","synonyms":["ALK- ALCL","ALK- chłoniak anaplastyczny z dużych komórek"]},"cs":{"name":"ALK-negativní anaplastický velkobuněčný lymfom","synonyms":["ALK- ALCL","ALK - anaplastický velkobuněčný lymfom"]},"uk":{"name":"ALK-негативна анапластична великоклітинна лімфома","synonyms":["ALK- ALCL","ALK - анапластична великоклітинна лімфома"],"definition":"A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK)."},"zh":{"name":"ALK阴性间变性大细胞淋巴瘤","synonyms":["ALK间变性大细胞淋巴瘤"],"definition":"一种ALCL，罕见的侵袭性外周T细胞非霍奇金淋巴瘤，累及淋巴结和结外部位，其特征为间变性淋巴瘤激酶（ALK）表达缺乏。"},"tr":{"name":"ALK negatif anaplastik büyük hücreli lenfoma","synonyms":["ALK- ALCL","ALK- anaplastik büyük hücreli lenfoma"]}},"xrefs":[{"source":"ICD-10","code":"C84.7","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2A90.B","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1179967777"},{"source":"ICD-11","code":"XH9T74","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1359106894"},{"source":"MONDO","code":"0017603","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1332078","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":98841,"name":"Anaplastic large cell lymphoma","classifications":[194,202,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}