{"orpha":300888,"name":"Diffuse large B-cell lymphoma with chronic inflammation","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["DLBCL with chronic inflammation"],"definition":"Diffuse large B-cell lymphoma with chronic inflammation is an Epstein-Barr virus-associated malignant lymphoproliferative disorder, developing in a context of long-standing or slow-growing, chronically inflamed lesions, such as chronic pyothorax, metallic implants in bones and joints, chronic osteomyelitis, chronic venous ulcer, or, rarely granulomatous inflammation. The tumor is usually primarily localized, with no involvement of other organs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-300888/","orphanet_url":"https://www.orpha.net/en/disease/detail/300888","names":{"fr":{"name":"Lymphome diffus à grandes cellules B avec inflammation chronique","synonyms":["DLBCL avec inflammation chronique"],"definition":"Une maladie lymphoproliférative maligne associée au virus d'Epstein-Barr, se manifestant dans un contexte de lésions lentement progressives, ou de lésions présentes depuis une longue période, associées à une inflammation chronique, comme un pyothorax chronique, la présence d'implants métalliques dans les os et les articulations, une ostéomyélite chronique, un ulcère veineux chronique, ou rarement, une inflammation granulomateuse. Habituellement, la tumeur se trouve sur le site primaire, sans atteinte d'autres organes."},"de":{"name":"B-Zell-Lymphom, diffuses großzelliges, mit chronischer Entzündung","synonyms":["DLBCL bei chronischer Entzündung"],"definition":"Das diffuse großzellige B-Zell-Lymphom mit chronischer Entzündung ist eine Epstein-Barr-Virus-assoziierte maligne lymphoproliferative Erkrankung, die sich im Zusammenhang mit langjährigen oder langsam wachsenden, chronisch entzündlichen Läsionen entwickelt, wie z. B. chronisches Pleuraempyem, metallische Implantate in Knochen und Gelenken, chronische Osteomyelitis, chronische venöse Ulzera oder, selten, granulomatöse Entzündungen. Der Tumor ist meist primär lokalisiert, ohne Beteiligung anderer Organe."},"es":{"name":"Linfoma difuso de células B grandes con inflamación crónica","synonyms":["DLBCL con inflamación crónica","LDCBG con inflamación crónica"],"definition":"Es un trastorno linfoproliferativo maligno asociado al virus de Epstein-Barr, que se desarrolla en un contexto de lesiones inflamatorias crónicas de larga duración o de crecimiento lento, tales como piotórax crónico, implantes metálicos en huesos y articulaciones, osteomielitis crónica, úlcera venosa crónica o, rara vez, inflamación granulomatosa. Por lo general, el tumor está localizado, sin afectación de otros órganos."},"it":{"name":"Linfoma diffuso a grandi cellule B con infiammazione cronica","synonyms":["DLBCL con infiammazione cronica"],"definition":"Il linfoma diffuso a grandi cellule B con infiammazione cronica è una malattia linfoproliferativa maligna associata al virus di Epstein-Barr, che si sviluppa nel contesto di lesioni infiammatorie croniche, presenti da lunga data, oppure a progressione lenta, come un piotorace cronico, impianti metallici nelle ossa e nelle articolazioni, osteomielite cronica, ulcere venose croniche o, raramente, un'infiammazione granulomatosa. Di solito il tumore si localizza nel sito primitivo e non interessa gli altri organi."},"nl":{"name":"Diffuus grootcellig B-cellymfoom met chronische ontsteking","synonyms":["DLBCL met chronische ontsteking"],"definition":"Diffuus grootcellig B-cellymfoom met chronische ontsteking is een kwaadaardige lymfoproliferatieve stoornis die is geassocieerd met Epstein-Barr virus, en die zich ontwikkelt in een context van langdurige of traag groeiende, chronisch ontstoken laesies, zoals chronische pyothorax, metalen implantaten in botten en gewrichten, chronische osteomyelitis, chronisch veneus ulcus, of, zelden, granulomateuze inflammatie. De tumor is meestal primair gelokaliseerd, zonder betrokkenheid van andere organen."},"pt":{"name":"Linfoma difuso de células B grandes com inflamação crónica"},"pl":{"name":"Chłoniak rozlany z dużych komórek B z przewlekłym zapaleniem","synonyms":["DLBCL z przewlekłym zapaleniem"]},"cs":{"name":"Difuzní velkobuněčný B-lymfom s chronickým zánětem","synonyms":["DLBCL s chronickým zánětem"]},"uk":{"name":"Дифузна велика В-клітинна лімфома з хронічним запаленням","synonyms":["DLBCL з хронічним запаленням"],"definition":"Diffuse large B-cell lymphoma with chronic inflammation is an Epstein-Barr virus-associated malignant lymphoproliferative disorder, developing in a context of long-standing or slow-growing, chronically inflamed lesions, such as chronic pyothorax, metallic implants in bones and joints, chronic osteomyelitis, chronic venous ulcer, or, rarely granulomatous inflammation. The tumor is usually primarily localized, with no involvement of other organs."},"zh":{"name":"慢性炎症相关弥漫大B细胞淋巴瘤","synonyms":["慢性炎症相关弥漫大B细胞淋巴瘤"],"definition":"弥漫性大B细胞淋巴瘤伴慢性炎症是一种与EB病毒相关的恶性淋巴增生性疾病，为长期缓慢生长的慢性炎性病，如慢性脓胸、骨关节内金属植入物、慢性骨髓炎、慢性静脉溃疡或偶见肉芽肿性炎症。肿瘤常为局灶性，不累及其他器官。"},"tr":{"name":"Kronik iltihap ile seyreden diffüz büyük B-hücreli lenfoma","synonyms":["Kronik iltihaplı DLBCL"]}},"xrefs":[{"source":"ICD-10","code":"C83.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017601","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4511460","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":544,"name":"Diffuse large B-cell lymphoma","classifications":[194,202,233]},{"orpha":289644,"name":"Epstein-Barr virus-associated malignant lymphoproliferative disorder","classifications":[202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}