{"orpha":293807,"name":"Ketamine-induced biliary dilatation","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Ketamine-induced biliary dilatation is an acquired biliary tract disease caused by the abusive consumption of ketamine, which results in the fusiform dilatation of the common bile ducts (CBD) without obstructive lesions or dilatation of the intrahepatic biliary ducts. Possible manifestations of the underlying cholangiopathy include epigastric pain and impaired liver function. Severity of CBD dilatation appears to correlate with the duration of ketamine consumption and the condition has been reported to be reversible in abstinent patients.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-293807/","orphanet_url":"https://www.orpha.net/en/disease/detail/293807","names":{"fr":{"name":"Dilatation des voies biliaires induite par la kétamine","definition":"Maladie acquise des voies biliaires causée par la consommation abusive de kétamine, entraînant une dilatation fusiforme des voies biliaires communes sans lésions obstructives ni dilatation des voies biliaires intrahépatiques. Les manifestations possibles de la cholangiopathie sous-jacente comprennent des douleurs épigastriques et une altération de la fonction hépatique. La gravité de la dilatation des voies biliaires communes semble être corrélée à la durée de la consommation de kétamine. La maladie serait réversible chez les patients en sevrage."},"de":{"name":"Gallengangdilatation, Ketamine-induzierte"},"es":{"name":"Dilatación biliar inducida por ketamina","definition":"Es una enfermedad adquirida del tracto biliar causada por un consumo excesivo de ketamina, en la que se produce una dilatación fusiforme de los conductos biliares comunes (CDB) sin lesiones obstructivas ni dilatación de los conductos biliares intrahepáticos. Las posibles manifestaciones de la colangiopatía incluyen dolor epigástrico y alteraciones de la función hepática. La magnitud de la dilatación de los CDB parece estar relacionada con la duración del consumo de ketamina y se ha descrito que la alteración es reversible tras suspender el consumo."},"it":{"name":"Dilatazione biliare indotta dalla ketamina","definition":"La dilatazione biliare indotta dalla ketamina è una malattia acquisita delle vie biliari, causata dall'eccesivo consumo di ketamina, che esita nella dilatazione fusiforme dei dotti biliari comuni (CBD) senza lesioni ostruttive o dilatazione dei dotti biliari intraepatici. Potenziali sintomi della colangiopatia sono il dolore epigastrico e la compromissione della funzionalità epatica. La gravità della dilatazione dei CBD sembra correlare con la durata dell'assunzione della ketamina. La malattia è reversibile nei pazienti che interrompono l'assunzione del farmaco."},"nl":{"name":"Ketaminegeïnduceerde galdilatatie","definition":"Ketaminegeïnduceerde galdilatatie is een verworven ziekte van de galwegen die veroorzaakt wordt door overmatig gebruik van ketamine, wat leidt tot de fusiforme dilatatie van de galgang, zonder obstructieve letsels of dilatatie van de intrahepatische galwegen. Mogelijke manifestaties van de onderliggende cholangiopathie zijn onder meer epigastrische pijn en verstoorde leverfunctie. De ernst van galgangdilatatie lijkt gecorreleerd te zijn met de duur van de ketamineconsumptie en er werd gerapporteerd dat de conditie omkeerbaar is bij abstinente patiënten."},"pt":{"name":"Dilatação biliar induzida por quetamina"},"pl":{"name":"Rozszerzenie przewodów żółciowych wzbudzane ketaminą"},"cs":{"name":"Ketaminem indukovaná dilatace žlučových cest"},"uk":{"name":"Дилатація жовчовивідних шляхів, спричинена кетаміном","definition":"Ketamine-induced biliary dilatation is an acquired biliary tract disease caused by the abusive consumption of ketamine, which results in the fusiform dilatation of the common bile ducts (CBD) without obstructive lesions or dilatation of the intrahepatic biliary ducts. Possible manifestations of the underlying cholangiopathy include epigastric pain and impaired liver function. Severity of CBD dilatation appears to correlate with the duration of ketamine consumption and the condition has been reported to be reversible in abstinent patients."},"zh":{"name":"氯胺酮诱导的胆管扩张","definition":"氯胺酮诱发胆管扩张是一种滥用氯胺酮引起的后天性胆道疾病，在无梗阻或肝内胆管扩张时导致正常胆管 (CBD)梭形扩张。胆管病变可表现为上腹痛和肝功能受损。CBD扩张程度与氯胺酮代谢时间相关，据报道，这种情况在戒断患者中是可逆的。"},"tr":{"name":"Ketamin-kaynaklı biliyer dilatasyon"}},"xrefs":[{"source":"ICD-10","code":"X44","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"NE60","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017394","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4512018","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":306640,"name":"Rare intoxication due to medical products","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":2.0,"area":"Worldwide","status":"Validated","source":"22124288[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_22124288[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-10-27","source":"22124288[PMID]","terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012440","label":"Abnormal biliary tract morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100518","label":"Dysuria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Very frequent (99-80%)","criteria":null}]}}