{"orpha":293,"name":"Congenital herpes simplex virus infection","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Antenatal herpes simplex virus infection","Mother-to-child transmission of herpes simplex virus infection"],"definition":"Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent foetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-293/","orphanet_url":"https://www.orpha.net/en/disease/detail/293","names":{"fr":{"name":"Infection congénitale à herpes simplex","synonyms":["Infection anténatale à herpes simplex"],"definition":"La foetopathie herpétique désigne l'ensemble des anomalies présentées par un enfant à la suite d'une infection maternelle par le virus de l'herpès suivie d'une infection foetale. Ce virus est responsable d'infections cutanées récurrentes chez l'adulte souvent au niveau des lèvres et des organes génitaux. Les infections herpétiques des autres organes, tels que le foie ou le système nerveux central, sont moins fréquentes."},"de":{"name":"Herpes simplex-Virusinfektion, kongenitale","synonyms":["Herpes simplex-Virusinfektion durch Mutter-Kind-Übertragung","Herpesvirus-Infektion, pränatale"],"definition":"Die Herpes-Foetopathie umfaßt eine Gruppe von Anomalien, die das Kind aufweist, wenn eine Herpes-Infektion in der Schwangerschaft von der Mutter auf den Foeten übertragen wurde. Das Virus verursacht bei Erwachsenen rezidivierende kutane Infektionen, oft im Bereich der Lippen oder Genitalien. Seltener sind Herpes-Infektionen anderer Organe, z.B. der Leber oder des Zentralnervensystems."},"es":{"name":"Infección congénita por el virus del herpes simple","synonyms":["Infección prenatal por el virus del herpes simple","Transmisión materna de la infección por el virus del herpes simple"],"definition":"La infección congénita por el virus del herpes es un grupo de anomalías que un niño puede presentar como resultado de la infección materna y posterior infección fetal con el virus del herpes. Este virus causa infecciones cutáneas recurrentes en los adultos, a menudo en los labios o los genitales. Las infecciones por herpes en otros órganos, como el hígado o el sistema nervioso central, son menos frecuentes."},"it":{"name":"Infezione congenita da virus dell'herpes","synonyms":["Infezione prenatale da virus dell'herpes"]},"nl":{"name":"Congenitale infectie met herpes-simplexvirus","synonyms":["Prenatale infectie met herpes-simplexvirus","Transmissie van moeder op kind van infectie met herpes-simplexvirus"],"definition":"Congenitale infectie met herpesvirus is een groep van anomalieën die een zuigeling kan vertonen als gevolg van maternale infectie en daaropvolgend foetale infectie met herpesvirus. Dit virus veroorzaakt terugkerende cutane infecties bij volwassenen, vaak met betrokkenheid van lippen of geslachtsorganen. Infectie met herpes in andere organen, zoals lever of centraal zenuwstelsel, komen minder vaak voor."},"pt":{"name":"Infeção por herpes vírus congénita","synonyms":["Infeção pré-natal por herpes vírus"]},"pl":{"name":"Wrodzone zakażenie herpeswirusowe","synonyms":["Prenatalne zakażenie herpeswirusowe"]},"cs":{"name":"Vrozená infekce herpes virem","synonyms":["Prenatální infekce herpes virem"]},"uk":{"name":"Вроджена інфекція простого герпесу","synonyms":["Антенатальна інфекція вірусом простого герпесу","Передача інфекції простого герпесу від матері до дитини"],"definition":"Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent foetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent."},"zh":{"name":"先天性单纯疱疹病毒感染","synonyms":["母婴传播性单纯疱疹病毒感染"]},"tr":{"name":"Doğumsal herpes simpleks virüsü enfeksiyonu","synonyms":["Antenatal herpes simplex virüs enfeksiyonu","Herpes simpleks virüs enfeksiyonunun anneden çocuğa bulaşması"]}},"xrefs":[{"source":"ICD-10","code":"P35.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1F00.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true,"icd11_uri":"null"},{"source":"MONDO","code":"0017381","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4275250","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":232035,"name":"Infectious embryofetopathy","classifications":[147,203,216]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Antenatal","Neonatal"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.6,"area":"Sweden","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.6,"area":"United Kingdom","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0001511","label":"Intrauterine growth retardation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002324","label":"Hydranencephaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000252","label":"Microcephaly","frequency":"Occasional (29-5%)","criteria":null}]}}