{"orpha":292,"name":"Congenital enterovirus infection","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Antenatal enterovirus infection","Mother-to-child transmission of enterovirus infection"],"definition":"An infectious embryofetopathy including coxsackie viruses and ECHO viruses that have been reported to cause spontaneous abortion, stillbirth, acute systemic illness in the newborn, and possibly fetal malformations.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-292/","orphanet_url":"https://www.orpha.net/en/disease/detail/292","names":{"fr":{"name":"Infection congénitale à entérovirus","synonyms":["Infection anténatale aux entérovirus"],"definition":"Embryofoetopathie infectieuse regroupant les virus Coxsackie et les virus ECHO qui seraient responsables d'avortement spontané, de mort foetale, de maladie systémique aiguë chez le nouveau-né et éventuellement de malformations foetales."},"de":{"name":"Enterovirus-Infektion, kongenitale","synonyms":["Enteroviren-Infektion, vorgeburtliche","Enterovirus-Infektion durch Mutter-Kind-Übertragung","Enterovirus-Infektion, pränatale"],"definition":"Eine infektiöse Embryofetopathie, die durch Coxsackie- und ECHO-Viren hervorgerufen wird und Spontanaborte, Totgeburten, akute systemische Erkrankungen des Neugeborenen und möglicherweise fetale Missbildungen verursacht."},"es":{"name":"Infección congénita por enterovirus","synonyms":["Infección prenatal por enterovirus","Transmisión materna de infección por enterovirus","Transmisión materna de la infección por enterovirus"],"definition":"Es una embriopatía infecciosa que incluye los virus coxsackie y ECHO, en la que se ha descrito aborto espontáneo, mortinatalidad, enfermedad sistémica aguda en el neonato y posibles malformaciones fetales."},"it":{"name":"Infezione congenita da enterovirus","synonyms":["Infezione prenatale da enterovirus"],"definition":"Si tratta di un'embrio/fetopatia infettiva da enterovirus, compresi i virus coxsackie e gli echovirus, che possono causare aborto spontaneo, morte perinatale, malattia sistemica acuta nel neonato e malformazioni fetali."},"nl":{"name":"Congenitale infectie door enterovirus","synonyms":["Prenatale infectie door enterovirus","Transmissie van moeder op kind van enterovirusinfectie"],"definition":"Een infectieuze embryofoetopathie, inclusief infectie door coxsackievirussen en ECHO-virussen, waarvan gemeld werd dat het spontane abortus, doodgeboorte, acute systemische ziekte bij neonaten, en mogelijk foetale malformaties veroorzaakt."},"pt":{"name":"Infeção congénita por Enterovírus","synonyms":["Infeção pré-natal por Enterovírus"]},"pl":{"name":"Wrodzone zakażenie enterowirusem","synonyms":["Prenatalne zakażenie enterowirusem"]},"cs":{"name":"Vrozená enterovirová infekce","synonyms":["Antenatální enterovirová infekce"]},"uk":{"name":"Вроджена ентеровірусна інфекція","synonyms":["Антенатальна ентеровірусна інфекція","Передача ентеровірусної інфекції від матері до дитини"],"definition":"An infectious embryofetopathy including coxsackie viruses and ECHO viruses that have been reported to cause spontaneous abortion, stillbirth, acute systemic illness in the newborn, and possibly fetal malformations."},"zh":{"name":"先天性肠病毒感染","synonyms":["母婴传播的肠道病毒感染"]},"tr":{"name":"Doğumsal enterovirüs enfeksiyonu","synonyms":["Antenatal enterovirüs enfeksiyonu","Enterovirüs enfeksiyonunun anneden çocuğa bulaşması"]}},"xrefs":[{"source":"ICD-10","code":"P35.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"KA62.5","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1981771784"},{"source":"MONDO","code":"0017375","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4274223","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"2130","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":232035,"name":"Infectious embryofetopathy","classifications":[147,203,216]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Antenatal","Neonatal"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-10-31","source":"25126719[PMID]_28373042[PMID]","terms":[{"hpo":"HP:0000988","label":"Skin rash","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025031","label":"Abnormality of the digestive system","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002086","label":"Abnormality of the respiratory system","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011121","label":"Abnormal skin morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200149","label":"CSF lymphocytic pleiocytosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001638","label":"Cardiomyopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001396","label":"Cholestasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001558","label":"Decreased fetal movement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001875","label":"Decreased total neutrophil count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001791","label":"Fetal ascites","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025116","label":"Fetal distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001789","label":"Hydrops fetalis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003073","label":"Hypoalbuminemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012758","label":"Neurodevelopmental delay","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001698","label":"Pericardial effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001561","label":"Polyhydramnios","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002119","label":"Ventriculomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004311","label":"Abnormal macrophage morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001987","label":"Hyperammonemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002045","label":"Hypothermia","frequency":"Very rare (<4-1%)","criteria":null}]}}