{"orpha":2912,"name":"Poliomyelitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare viral infection caused by any of three serotypes of wild human poliovirus (types 1, 2 and 3), which are part of the family of enteroviruses; and three serotypes of Sabin vaccine-derived polioviruses (types 1, 2 and 3) that have accumulated genetic changes and regained the ability to cause polio paralysis. wild type 2 and type 3 polioviruses have been certified eradicated, wild type&nbsp;1 poliovirus continues to circulate in Pakistan and Afghanistan, and vaccine-derived polio viruses mainly circulate in sub-Saharan Africa.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2912/","orphanet_url":"https://www.orpha.net/en/disease/detail/2912","names":{"fr":{"name":"Poliomyélite","definition":"Infection virale rare causée par l'un des trois sérotypes du poliovirus sauvage humain (types 1, 2 et 3), qui font partie de la famille des entérovirus, et par les trois sérotypes des poliovirus dérivés du vaccin de Sabin (types 1, 2 et 3) qui ont accumulé des mutations génétiques et ont retrouvé la capacité de provoquer une paralysie poliomyélitique. Alors que l'éradication des poliovirus sauvages de type&nbsp;2 et de type&nbsp;3 a été certifiée, le poliovirus sauvage de type&nbsp;1 continue de circuler au Pakistan et en Afghanistan, et les poliovirus dérivés du vaccin circulent principalement en Afrique subsaharienne."},"de":{"name":"Poliomyelitis","definition":"Poliomyelitis ist eine Virusinfektion, die durch einen der drei Serotypen des humanen Poliovirus verursacht wird, das zur Familie der Enteroviren gehört."},"es":{"name":"Poliomielitis","definition":"La poliomielitis es una infección viral causada por cualquiera de los tres serotipos del poliovirus humano, que es parte de la familia de los enterovirus."},"it":{"name":"Poliomielite","definition":"La poliomielite è un'infezione virale causata da qualsiasi dei 3 sierotipi del poliovirus umano, che appartiene alla famiglia degli enterovirus."},"nl":{"name":"Poliomyelitis","definition":"Een zeldzame virale infectie veroorzaakt door een van de drie serotypes van wildtype humaan poliovirus (types 1, 2 en 3), die behoren tot de familie van enterovirussen, en drie serotypes van poliovirus afgeleid van Sabin-vaccin (poliovaccinvirussen types 1, 2 en 3) die genetische veranderingen hebben ondergaan en het vermogen om kinderverlamming te veroorzaken hebben herwonnen. Wildtype 2 en 3 poliovirussen werden officieel uitgeroeid, terwijl wildtype 1 poliovirus nog circuleert in Pakistan en Afghanistan, en poliovaccinvirussen vooral circuleren in Sub-Sahara-Afrika."},"pt":{"name":"Poliomielite"},"pl":{"name":"Ostre nagminne porażenie dziecięce","definition":"Poliomyelitis to infekcja wirusowa wywołana przez jeden z trzech serotypów ludzkiego wirusa polio, który należy do rodziny enterowirusów."},"cs":{"name":"Poliomyelitida","synonyms":["Dětská obrna"]},"uk":{"name":"Поліомієліт","definition":"Poliomyelitis is a viral infection caused by any of three serotypes of human poliovirus, which is part of the family of enteroviruses."},"zh":{"name":"脊髓灰质炎"},"tr":{"name":"Çocuk felci"}},"xrefs":[{"source":"ICD-10","code":"A80.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A80.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A80.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A80.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A80.4","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A80.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C81","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"588527933"},{"source":"MONDO","code":"0017373","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D011051","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0032371","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7413","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10036012","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":330009,"name":"OBSOLETE: Poliomyelitis in patients with immunodeficiencies deemed at risk","status":"inactive"}],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98506,"name":"Acquired motor neuron disease","classifications":[181]},{"orpha":98010,"name":"Infectious disease of the nervous system","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-02-28","source":"31690950[PMID]_8944203[PMID]","terms":[{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012531","label":"Pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0040131","label":"Abnormal motor nerve conduction velocity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011805","label":"Abnormal skeletal muscle morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001284","label":"Areflexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001348","label":"Brisk reflexes","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003546","label":"Exercise intolerance","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0009004","label":"Hypoplasia of the musculature","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031469","label":"Low self esteem","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007340","label":"Lower limb muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010547","label":"Muscle flaccidity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012486","label":"Myelitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003202","label":"Skeletal muscle atrophy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030813","label":"Absent tonsils","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001283","label":"Bulbar palsy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002483","label":"Bulbar signs","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002374","label":"Diminished movement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001618","label":"Dysphonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002380","label":"Fasciculations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030196","label":"Fatigable weakness of respiratory muscles","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002487","label":"Hyperkinetic movements","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031058","label":"Impairment of activities of daily living","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002540","label":"Inability to walk","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002590","label":"Paralytic ileus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002385","label":"Paraparesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004887","label":"Respiratory failure requiring assisted ventilation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003484","label":"Upper limb muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000713","label":"Agitation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031274","label":"Hypovolemic shock","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Very rare (<4-1%)","criteria":null}]}}