{"orpha":289356,"name":"Primary non-gestational choriocarcinoma of ovary","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["NGCO","Primary non-gestational ovarian choriocarcinoma"],"definition":"Primary non-gestational choriocarcinoma of ovary is a rare ovarian germ cell malignant tumor, arising from primordial germ cells, usually presenting with nausea, vomiting, abdominal pain, menstrual irregularities, and characterized by fast growth pattern, metastasis to lung, liver and brain and production of human chorionic gonadotrophin (hCG). It is apparently chemoresistant and has a worse prognosis than gestational choriocarcinoma and hence should be distinguished from the latter by DNA polymorphism.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-289356/","orphanet_url":"https://www.orpha.net/en/disease/detail/289356","names":{"fr":{"name":"Choriocarcinome ovarien primitif non gestationnel","synonyms":["Choriocarcinome primitif non gestationnel de l'ovaire","NGCO"],"definition":"Tumeur maligne ovarienne germinale se développant à partir des cellules germinales primordiales, se manifestant généralement par des nausées, des vomissements, des douleurs abdominales, un cycle menstruel irrégulier, et caractérisée par une croissance rapide, des métastases aux poumons, au foie et au cerveau, et la production de gonadotrophine chorionique humaine (hCG). La tumeur s'avère résistante à la chimiothérapie et son pronostic est moins favorable que celui du choriocarcinome gestationnel. Il convient donc de la distinguer de ce dernier par le polymorphisme de l'ADN."},"de":{"name":"Primäres nicht-gestationales Chorionkarzinom des Ovars","synonyms":["NGCO","Ovarielles Chorionkarzinom, nicht-gestationales primäres","Primäres Chorionkarzinom des Ovars","Primäres nicht-gestationales ovarielles Chorionkarzinom"]},"es":{"name":"Coriocarcinoma primario no gestacional de ovario","synonyms":["Coriocarcinoma ovárico primario no gestacional","NGCO"],"definition":"Es un tumor maligno poco frecuente de células germinales de ovario que surge de las células germinales primordiales y que, por lo general, se manifiesta como náuseas, vómitos, dolor abdominal e irregularidades menstruales. Está caracterizado por un patrón de crecimiento rápido, metástasis en los pulmones, hígado y cerebro y por la producción de gonadotropina coriónica humana (GCh). Aparentemente es quimiorresistente y tiene un peor pronóstico que el coriocarcinoma gestacional y, por lo tanto, debe distinguirse de éste último por los polimorfismos en el ADN."},"it":{"name":"Coriocarcinoma dell'ovaio non gestazionale primitivo","synonyms":["Coriocarcinoma ovarico non gestazionale primitivo","NGCO"]},"nl":{"name":"Primair niet-gestationeel choriocarcinoom van ovarium","synonyms":["NGCO","Primair niet-gestationeel choriocarcinoom van eierstok","Primair niet-gestationeel ovarieel choriocarcinoom"],"definition":"Primair niet-gestationeel choriocarcinoom van het ovarium is een zeldzame maligne kiemceltumor van het ovarium (zie deze term) die ontstaat uit primordiale kiemcellen, zich manifesteert met misselijkheid, braken, pijn in de buik en onregelmatigheden bij de menstruatie, en gekarakteriseerd wordt door een snelle groei, uitzaaiing naar de long, lever en hersenen en aanmaak van humaan choriongonadotrofine (hCG). Deze tumor blijkt chemoresistent en heeft een ongunstigere prognose dan gestationeel choriocarcinoom (zie deze term), en dus dient het hiervan onderscheiden te worden door DNA-polymorfisme."},"pt":{"name":"Coriocarcinoma ovárico não gestacional","synonyms":["NGCO"]},"pl":{"name":"Pierwotny nieciążowy rak kosmówkowy jajnika","synonyms":["NGCO"]},"cs":{"name":"Primární non-gestační choriokarcinom ovária","synonyms":["NGCO","Primární non-gestační ovariální choriokarcinom"]},"uk":{"name":"Первинна негестаційна хоріокарцинома яєчника","synonyms":["NGCO","Первинна негестаційна хоріокарцинома яєчників"],"definition":"Primary non-gestational choriocarcinoma of ovary is a rare ovarian germ cell malignant tumor (see this term), arising from primordial germ cells, usually presenting with nausea, vomiting, abdominal pain, menstrual irregularities, and characterized by fast growth pattern, metastasis to lung, liver and brain and production of human chorionic gonadotrophin (hCG). It is apparently chemoresistant and has a worse prognosis than gestational choriocarcinoma (see this term) and hence should be distinguished from the latter by DNA polymorphism."},"zh":{"name":"原发性非妊娠卵巢绒毛膜癌","synonyms":["卵巢原发性非妊娠性绒毛膜癌"],"definition":"原发性非妊娠性卵巢绒毛膜癌是一种罕见的卵巢生殖细胞恶性肿瘤（见本术语），起源于原始生殖细胞，通常表现为恶心、呕吐、腹痛、月经不调，其特点是生长快、向肺，肝和脑转移，并产生人绒毛膜促性腺激素（hCG）。与妊娠性绒毛膜癌（见本术语）相比，它对化疗耐药，预后更差，因此需通过DNA多态性来区别。"},"tr":{"name":"Yumurtalıkların primer gestasyonel olmayan koryokarsinomu","synonyms":["NGCO","Primer gebelik dışı yumurtalık koriyokarsinomu"]}},"xrefs":[{"source":"ICD-10","code":"C56","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C73.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1138803134"},{"source":"MONDO","code":"0017327","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4274424","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":35807,"name":"Malignant germ cell tumor of ovary","classifications":[202,205,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["Adolescent"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}