{"orpha":284400,"name":"Small cell carcinoma of the bladder","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Poorly differentiated neuroendocrine carcinoma of the bladder","SCCB","Small cell bladder cancer","Small cell bladder carcinoma","Small cell carcinoma of the urinary bladder"],"definition":"Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-284400/","orphanet_url":"https://www.orpha.net/en/disease/detail/284400","names":{"fr":{"name":"Carcinome à petites cellules de la vessie","synonyms":["Cancer à petites cellules de la vessie","Carcinome neuroendocrine primitif de la vessie","SCCB","Tumeur neuroendocrine à petites cellules de la vessie"],"definition":"Le carcinome à petites cellules de la vessie (CPCV) est une tumeur épithéliale neuroendocrine peu différenciée et très rare de la vessie, dont les symptômes cliniques sont une hématurie et/ou une dysurie ainsi qu'une évolution agressive."},"de":{"name":"Blasenkarzinom, kleinzelliges","synonyms":["Blasenkrebs, kleinzelliger","SCCB","Undifferenziertes neuroendokrines Blasenkarzinom"],"definition":"Das kleinzellige Blasenkarzinom (SCCB) ist ein sehr seltener, wenig differenzierter, neuroendokriner epithelialer Blasentumor und klinisch durch Hämaturie und/oder Dysurie und einen hoch-aggressiven Verlauf gekennzeichnet."},"es":{"name":"Carcinoma de células pequeñas de vejiga","synonyms":["Carcinoma de células pequeñas de la vejiga urinaria","Carcinoma de vejiga de células pequeñas","Carcinoma neuroendocrino pobremente diferenciado de la vejiga","Cáncer de vejiga de células pequeñas","SCCB"],"definition":"El carcinoma de células pequeñas de vejiga (SCCB) es un tumor neuroendocrino vesical epitelial poco diferenciado, caracterizado clínicamente por hematuria y/o disuria, y un curso muy agresivo."},"it":{"name":"Carcinoma a piccole cellule della vescica","synonyms":["Cancro a piccole cellule della vescica","Carcinoma a piccole cellule della vescica urinaria","Carcinoma neuroendocrino scarsamente differenziato della vescica","SCCB"],"definition":"Il carcinoma a piccole cellule della vescica (SCCB) è un tumore neuroendocrino dell'epitelio della vescica scarsamente differenziato, molto raro, clinicamente caratterizzato da ematuria e/o disuria e con un decorso molto aggressivo."},"nl":{"name":"Kleincellig carcinoom van blaas","synonyms":["Kleincellig blaascarcinoom","Kleincellig carcinoom van urineblaas","Kleincellige blaaskanker","SCCB","Slecht gedifferentieerd neuro-endocrien carcinoom van blaas"],"definition":"Kleincellig carcinoom van de blaas (SCCB) is een zeer zeldzame, slecht gedifferentieerde neuroendocriene epitheliale blaastumor, klinisch gekenmerkt door hematurie en/of dysurie en een uitermate agressief verloop."},"pt":{"name":"Carcinoma das células pequenas da bexiga","definition":"O carcinoma de células pequenas da bexiga (SCCB) é tumor pouco diferenciado muito raro do epitélio neuroendócrino da bexiga, caracterizado clinicamente por hematúria e/ou disúria e um curso altamente agressivo."},"pl":{"name":"Drobnokomórkowy rak pęcherza moczowego","synonyms":["Drobnokomórkowy nowotwór pęcherza moczowego","Nowotwór drobnokomórkowy pęcherzyka żółciowego","Rak drobnokomórkowy pęcherzyka żółciowego","SCCB","Słabo zróżnicowany neuroendokrynny rak pęcherza moczowego"]},"cs":{"name":"Malobuněčný karcinom močového měchýře","synonyms":["SCCB","Nediferencovaný neuroendokrinní karcinom močového měchýře","Malobuněčný zhoubný nádor močového měchýře"]},"uk":{"name":"Дрібноклітинний рак сечового міхура","synonyms":["Погано диференційована нейроендокринна карцинома сечового міхура","SCCB","Дрібноклітинний рак сечового міхура","Дрібноклітинна карцинома сечового міхура","Дрібноклітинний рак сечового міхура"],"definition":"Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course."},"zh":{"name":"膀胱小细胞癌","synonyms":["低分化膀胱神经内分泌癌"],"definition":"膀胱小细胞癌（SCCB）是一种非常罕见、分化不良的神经内分泌膀胱上皮肿瘤，临床表现为血尿和/或排尿困难，病程呈高度侵袭性。"},"tr":{"name":"Mesanenin küçük hücreli karsinomu","synonyms":["SCCB","Küçük hücreli mesane kanseri","Küçük hücreli mesane karsinomu","Mesanenin küçük hücreli karsinomu","Mesanenin kötü diferansiye nöroendokrin karsinomu"]}},"xrefs":[{"source":"ICD-10","code":"C67.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.1","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.2","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.3","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.4","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.5","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.6","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.7","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.8","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C67.9","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C13.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true,"icd11_uri":"null"},{"source":"MONDO","code":"0004114","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"4114","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1332564","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"11923","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":100101,"name":"Neuroendocrine tumor with other location","classifications":[193,202]},{"orpha":98058,"name":"Rare urinary tract tumor","classifications":[185,202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"United States","status":"Validated","source":"21567387[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0009725","label":"Bladder neoplasm","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100518","label":"Dysuria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003072","label":"Hypercalcemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000010","label":"Recurrent urinary tract infections","frequency":"Occasional (29-5%)","criteria":null}]}}