{"orpha":279925,"name":"Infectious panuveitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare ophthalmic disorder characterized by generalized inflammation of all parts of the uveal tract (iris, ciliary body, and choroid), simultaneously involving adjacent vitreous and retina, without any predominant site of inflammation, due to viral, bacterial, fungal, or parasitic infections. Clinical symptoms include pain, photophobia, redness, blurring of vision, and floaters. Signs on examination are lid edema, ciliary injection, chemosis, keratic precipitates, cells in the anterior chamber, hypopyon, iris nodules and neovascularization, posterior synechiae, macular edema, vitreous and retinal hemorrhage, and retinal detachment, among others. Complications may result in visual loss.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-279925/","orphanet_url":"https://www.orpha.net/en/disease/detail/279925","names":{"fr":{"name":"Panuvéite infectieuse","definition":"Maladie ophtalmique rare caractérisée par une inflammation généralisée de toutes les parties du tractus uvéal (iris, corps ciliaire et choroïde), affectant à la fois le vitré et la rétine adjacente, sans site prédominant d'inflammation, due à des infections virales, bactériennes, fongiques ou parasitaires. Les signes cliniques sont la douleur, la photophobie, la rougeur, la vision floue et des corps flottants. Les signes à l'examen incluent entre autres : oedème des paupières, injection ciliaire, chémosis, précipités kératiques, présence de cellules dans la chambre antérieure, hypopion, nodules et néovascularisation de l'iris, synéchies postérieures, oedème maculaire, hémorragie du vitré et de la rétine et décollement de la rétine. La perte de la vision fait partie des complications."},"de":{"name":"Panuveitis, infektiöse","definition":"Eine seltene Augenerkrankung, die durch eine generalisierte Entzündung aller Teile der Aderhaut (Iris, Ziliarkörper und Choroidea) gekennzeichnet ist, die gleichzeitig den angrenzenden Glaskörper und die Netzhaut mit einbezieht, ohne dass ein bestimmter Entzündungsherd vorherrscht, und die durch virale, bakterielle, pilzartige oder parasitäre Infektionen verursacht wird. Zu den klinischen Symptomen gehören Schmerzen, Photophobie, Rötung, verschwommenes Sehen und Floater. Anzeichen bei der Untersuchung sind u. a. Lidödem, Ziliareinspritzung, Chemose, keratische Präzipitate, Zellen in der Vorderkammer, Hypopyon, Irisknötchen und Neovaskularisationen, hintere Synechien, Makulaödem, Glaskörper- und Netzhautblutungen sowie Netzhautablösungen. Komplikationen können zu einem Sehverlust führen."},"es":{"name":"Panuveítis infecciosa","definition":"Es un trastorno oftalmológico poco frecuente caracterizado por una inflamación generalizada del tracto uveal (iris, cuerpo ciliar y coroides), afectando simultáneamente al vítreo y a la retina adyacentes, sin un sitio de inflamación predominante, debido a infecciones virales, bacterianas, fúngicas o parasitarias. Los síntomas clínicos incluyen dolor, fotofobia, enrojecimiento de los ojos, visión borrosa y miodesopsias. En la exploración los signos son: edema palpebral, inyección ciliar, quemosis, precipitados queráticos, células en la cámara anterior, hipopión, nódulos y neovascularización del iris, sinequias posteriores, edema macular, hemorragia vítrea y retiniana, desprendimiento de retina, entre otros. Las complicaciones pueden resultar en la pérdida visual."},"it":{"name":"Panuveite infettiva","definition":"Si tratta di una malattia oculare rara, caratterizzata dall'infiammazione generalizzata di tutte le parti del tratto uveale (iride, corpo ciliare e coroide), che interessa contemporaneamente il vitreo e la retina adiacenti, senza una localizzazione prevalente. La malattia è causata dalle infezioni virali, batteriche, micotiche o parassitarie. I segni clinici comprendono il dolore, la fotofobia, l'arrossamento, la vista offuscata e le miodesopsie. Alla valutazione clinica si riscontrano edema palpebrale, iniezione ciliare, chemosi, precipitati cheratici, presenza di cellule nella camera anteriore, ipopion, noduli e neovascolarizzazione dell'iride, sinechie posteriori, edema della macula, emorragia del vitreo e della retina, e distacco della retina. Le complicanze possono causare la cecità."},"nl":{"name":"Infectieuze panuveïtis","definition":"Een zeldzame aandoening van oog, gekarakteriseerd door gegeneraliseerde inflammatie van alle delen van uvea (iris, straallichaam, en vaatvlies), met simultane betrokkenheid van aangrenzend glasvocht en netvlies, zonder enige specifieke plaats waar de inflammatie overheerst, als gevolg van virale, bacteriële, fungale, of parasitaire infectie. Klinische symptomen zijn onder meer pijn, fotofobie, roodheid, troebel zicht, en glasvochttroebeling. Verschijnselen bij onderzoek zijn onder meer oedeem van ooglid, ciliaire injectie, chemose, keratitische precipitaten, cellen in voorste oogkamer, hypopyon, noduli en neovascularisatie van iris, posterieure synechieën, macula-oedeem, hemorragie van glasachtig lichaam en retina, en netvliesloslating. Complicaties kunnen leiden tot verlies van gezichtsvermogen."},"pt":{"name":"Panuveíte infeciosa"},"pl":{"name":"Zakaźne zapalenie wszystkich struktur błony naczyniowej oka"},"cs":{"name":"Infekční panuveitida"},"uk":{"name":"Інфекційний панувеїт","definition":"A rare ophthalmic disorder characterized by generalized inflammation of all parts of the uveal tract (iris, ciliary body, and choroid), simultaneously involving adjacent vitreous and retina, without any predominant site of inflammation, due to viral, bacterial, fungal, or parasitic infections. Clinical symptoms include pain, photophobia, redness, blurring of vision, and floaters. Signs on examination are lid edema, ciliary injection, chemosis, keratic precipitates, cells in the anterior chamber, hypopyon, iris nodules and neovascularization, posterior synechiae, macular edema, vitreous and retinal hemorrhage, and retinal detachment, among others. Complications may result in visual loss."},"zh":{"name":"感染性全葡萄膜炎"},"tr":{"name":"Bulaşıcı panüveit"}},"xrefs":[{"source":"ICD-10","code":"H44.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"9C20.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1709165622"},{"source":"MONDO","code":"0017211","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5230354","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97966,"name":"Rare ophthalmic disorder"},"parents":[{"orpha":280898,"name":"Panuveitis","classifications":[189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":4.4,"area":"United States","status":"Validated","source":"32841267[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}