{"orpha":276161,"name":"Multiple endocrine neoplasia","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["MEN"],"definition":"Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-276161/","orphanet_url":"https://www.orpha.net/en/disease/detail/276161","names":{"fr":{"name":"Néoplasie endocrinienne multiple","synonyms":["MEN"],"definition":"Groupe de syndromes cancéreux héréditaires rares caractérisés par le développement d'au moins deux tumeurs endocrines, parfois accompagnées de tumeurs touchant d'autres tissus ou organes."},"de":{"name":"Neoplasie, endokrine multiple","synonyms":["MEN"]},"es":{"name":"Neoplasia endocrina múltiple","synonyms":["MEN"],"definition":"Es un grupo de síndromes de cáncer hereditario poco frecuente caracterizados por el desarrollo de dos o más tumores en las glándulas endocrinas, acompañado en ocasiones de tumores en otros tejidos u órganos."},"it":{"name":"Neoplasia endocrina multipla","synonyms":["MEN"],"definition":"La neoplasia endocrina multipla (MEN) comprende un gruppo di sindromi tumorali ereditarie rare, caratterizzate dallo sviluppo di due o più tumori delle ghiandole endocrine, talvolta associati a tumori di altri tessuti o organi."},"nl":{"name":"Multipele endocriene neoplasie","synonyms":["MEN","Meervoudige endocriene neoplasie"],"definition":"Multipele endocriene neoplasie (MEN) is een groep van zeldzame erfelijke kankersyndromen die gekarakteriseerd worden door de ontwikkeling van twee of meer tumoren van endocriene klieren, soms met ontwikkeling van tumoren in andere weefsels of organen."},"pt":{"name":"Neoplasia endócrina múltipla"},"pl":{"name":"Zespół mnogiej gruczolakowatości wewnątrzwydzielniczej","synonyms":["MEN"]},"cs":{"name":"Mnohočetná endokrinní neoplázie","synonyms":["MEN"]},"uk":{"name":"Множинні ендокринні неоплазії","synonyms":["MEN"],"definition":"Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs."},"zh":{"name":"多发性内分泌肿瘤","synonyms":["MEN"],"definition":"多发性内分泌肿瘤(MEN)是一组罕见的遗传性癌症综合征，以两个或两个以上内分泌腺肿瘤的发展为特征，有时还伴有其他组织或器官的肿瘤发生。"},"tr":{"name":"Çoklu endokrin neoplazi","synonyms":["MEN"]}},"xrefs":[{"source":"ICD-10","code":"D44.8","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2F7A.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1141789488"},{"source":"MONDO","code":"0017169","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"17169","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009377","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0027662","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10028196","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":100094,"name":"Multiple polyglandular tumor","classifications":[156,193,202]}],"children":[{"orpha":652,"name":"Multiple endocrine neoplasia type 1","type":"Disease"},{"orpha":653,"name":"Multiple endocrine neoplasia type 2","type":"Disease"},{"orpha":276152,"name":"Multiple endocrine neoplasia type 4","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Autosomal dominant","Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Ireland","status":"Validated","source":"2575263[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET_[EXPERT]"}],"phenotypes":null}