{"orpha":2737,"name":"Onchocerciasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A form of filariasis, caused by the parasitic worm <i> Onchocerca volvulus</i>, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2737/","orphanet_url":"https://www.orpha.net/en/disease/detail/2737","names":{"fr":{"name":"Onchocercose","definition":"L'onchocercose est une forme de filariose causée par le ver parasitaire <i>Onchocerca volvulus</i> transmis par une mouche noire. L'infection peut soit être asymptomatique, ou se manifester par une atteinte oculaire (cécité des rivières) avec un prurit, un érythème, une photophobie, une onchodermatite ou une maladie onchocercale cutanée (classée en papulaire aiguë, papulaire chronique, lichenifiée, atrophique et dépigmentée) et un onchocercome (sur les proéminences osseuses). Les autres manifestations cliniques classiques sont des lésions de type ichtyose (« peau de lézard ») et une « aine pendante » qui peut être associée à une lymphadénopathie."},"de":{"name":"Onchozerkose"},"es":{"name":"Oncocercosis","definition":"Es una forma de filariasis causada por el gusano parásito <i>Onchocerca volvulus</i>, transmitido por la mosca negra. La infección puede ser asintomática o manifestarse como enfermedad ocular (ceguera de los ríos) con picazón en los ojos, eritema, fotofobia, oncodermatitis o dermatosis causada por onchocerca (clasificada en papular aguda, papular crónica, liquenizada, atrófica y despigmentada) y oncocercomas (sobre protuberancias óseas). Otras manifestaciones clínicas que pueden estar asociadas a linfoadenopatía, son las lesiones de tipo ictiósico (\"piel de lagarto\", ''lizard skin'') y linfoadenopatía inguinal (''hanging groin'')."},"it":{"name":"Oncocercosi","definition":"L'oncocercosi è una forma di filariosi (si veda questo termine), causata dal verme parassita <i> Onchocerca volvulus</i>, trasmessa dalla mosca nera. L'infezione può essere asintomatica o manifestarsi con una malattia oculare (cecità fluviale) associata al prurito agli occhi, eritema, fotofobia, oncodermatite o a una malattia cutanea da oncocercosi (classificata nei tipi: papulare acuta, papulare cronica, lichenizzata, atrofica, e depigmentata) e oncocercomi (sulle protuberanze ossee). Altri segni clinici tipici sono le lesioni simil-ittiosiche (\"pelle da lucertola\") e l'\"inguine appeso\", che possono associarsi a linfoadenopatia."},"nl":{"name":"Onchocerciase","definition":"Een vorm van filariasis veroorzaakt door de parasitaire worm <i>Onchocerca volvulus</i>, die wordt overgedragen door de zwarte vlieg. De infectie kan asymptomatisch zijn, of zich manifesteren als een oogaandoening (rivierblindheid) met jeukende ogen, erytheem, fotofobie, onchodermatitis of huidziekte door Onchocerca (onderverdeeld in acuut papulair, chronisch papulair, gelichenificeerd, atrofisch, en gedepigmenteerd) en onchocercomen (boven benige uitsteeksels). Andere gangbare klinische manifestaties zijn ichthyosis-achtige letsels (''hagedishuid'') en ''hangende lies'', mogelijk geassocieerd met lymfadenopathie."},"pt":{"name":"Oncocerciose"},"pl":{"name":"Onchocerkoza"},"cs":{"name":"Onchocerciáza"},"uk":{"name":"Онхоцеркоз","definition":"A form of filariasis, caused by the parasitic worm <i> Onchocerca volvulus</i>, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy."},"zh":{"name":"盘尾丝虫病"},"tr":{"name":"Onkoserkoz"}},"xrefs":[{"source":"ICD-10","code":"B73","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F6A","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"106136071"},{"source":"MONDO","code":"0017137","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009855","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0029001","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7252","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10030314","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":2034,"name":"Filariasis","classifications":[203]},{"orpha":716432,"name":"Rare isolated progressive predominantly macular disorder","classifications":[189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":">1 / 1000","value":0.0,"area":"Specific population","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}