{"orpha":264978,"name":"Drug or radiation exposure-related interstitial lung disease","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare secondary interstitial lung disease (ILD) characterized by development of the condition after exposure to certain drugs or radiation therapy. Diagnostic criteria include clear temporal association, identification of a characteristic reaction pattern to the respective drug, and exclusion of other causes of the ILD. Clinically, drug-induced ILD (DI-ILD) may occur as acute ILD with respiratory failure, or as subacute/chronic DI-ILD. Radiation injury to the lung can develop during or following radiation therapy and depends on the nature and dose of the ionizing radiation, as well as the direction of the radiation beam.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-264978/","orphanet_url":"https://www.orpha.net/en/disease/detail/264978","names":{"fr":{"name":"Pneumopathie interstitielle médicamenteuse ou secondaire à une exposition aux radiations","definition":"Pneumopathie interstitielle secondaire rare caractérisée par une apparition consécutive à une exposition à certains médicaments ou à la radiothérapie. Les critères de diagnostic comprennent un cadre temporel précis, l'identification d'un modèle de réaction caractéristique au médicament concerné et l'exclusion d'autres causes de la pneumopathie interstitielle. Sur le plan clinique, la pneumopathie interstitielle médicamenteuse peut se manifester par une pneumopathie interstitielle aiguë accompagnée d'une insuffisance respiratoire ou par une pneumopathie interstitielle subaiguë/chronique. Les lésions pulmonaires dues aux radiations peuvent survenir pendant ou après une radiothérapie et dépendent de la nature et de la dose d'irradiation, ainsi que de la direction du faisceau."},"de":{"name":"Interstitielle Lungenkrankheit, Substanz- oder Strahleninduzierte","definition":"Eine seltene sekundäre interstitielle Lungenerkrankung (ILD), die durch die Entwicklung der Erkrankung nach Exposition gegenüber bestimmten Medikamenten oder Strahlentherapie gekennzeichnet ist. Zu den diagnostischen Kriterien gehören ein eindeutiger zeitlicher Zusammenhang, die Identifizierung eines charakteristischen Reaktionsmusters auf das betreffende Medikament und der Ausschluss anderer Ursachen für die ILD. Klinisch kann die medikamenteninduzierte ILD (DI-ILD) als akute ILD mit Atemversagen oder als subakute/chronische DI-ILD auftreten. Strahlenschäden an der Lunge können sich während oder nach einer Strahlentherapie entwickeln und hängen von der Art und der Dosis der ionisierenden Strahlung sowie von der Richtung des Strahlenbündels ab."},"es":{"name":"Enfermedad pulmonar intersticial asociada a la exposición a fármacos o radiación","definition":"Es una enfermedad pulmonar intersticial (EPI) secundaria poco frecuente caracterizada por el desarrollo de la afección después de la exposición a ciertos medicamentos o radioterapia. Los criterios de diagnóstico incluyen una asociación temporal clara, la identificación de un patrón característico de reacción al fármaco respectivo y la exclusión de otras causas de EPI. Clínicamente, la EPI inducida por fármacos puede ocurrir como EPI aguda con insuficiencia respiratoria o como EPI inducida por fármacos subaguda/crónica. La lesión pulmonar por radiación puede desarrollarse durante o después de la radioterapia y depende de la naturaleza y la dosis de la radiación ionizante, así como de la dirección del haz de radiación."},"it":{"name":"Pneumopatia interstiziale da farmaci o esposizione a radiazioni"},"nl":{"name":"Interstitiële longziekte gerelateerd aan medicatie of radiatie","definition":"Een zeldzame secundaire interstitiële longziekte (ILD), gekenmerkt door ontwikkeling van de ziekte na blootstelling aan bepaalde geneesmiddelen of stralingstherapie. Diagnostische criteria zijn onder meer duidelijk temporeel verband, identificatie van een kenmerkend reactiepatroon tegen het desbetreffende geneesmiddel, en exclusie van andere oorzaken van ILD. Klinisch kan door geneesmiddel geïnduceerde ILD (DI-ILD) optreden als acute ILD met respiratoir falen, of als subacute/chronische DI-ILD. Letsel door straling aan long kan ontwikkelen tijdens of na stralingstherapie en hangt af van de aard en de dosis van de ioniserende straling, alsook van de richting van de straal."},"pt":{"name":"Doença pulmonar intersticial relacionada com exposição a fármacos ou radiação","definition":"Doença pulmonar intersticial (DPI) secundária rara caracterizada pelo desenvolvimento da doença após exposição a certos medicamentos ou radioterapia. Os critérios diagnósticos incluem associação temporal clara, identificação de um padrão de reação característico do respectivo medicamento e exclusão de outras causas de DPI. Clinicamente, a DPI induzida por medicamentos (DPI-IM) pode ocorrer como DPI aguda com insuficiência respiratória ou como DPI-IM subaguda/crónica. A lesão pulmonar por radiação pode desenvolver-se durante ou após a radioterapia e depende da natureza e da dose da radiação ionizante, bem como da direção do feixe de radiação."},"pl":{"name":"Śródmiąższowa choroba płuc zwiaząna z ekspozycją na leki lub promieniowanie"},"cs":{"name":"Intersticiální plicní nemoc související s expozicí lékům a radiaci"},"uk":{"name":"Інтерстиціальна хвороба легень, повязана з медикаментозним або радіаційним впливом","definition":"A rare secondary interstitial lung disease (ILD) characterized by development of the condition after exposure to certain drugs or radiation therapy. Diagnostic criteria include clear temporal association, identification of a characteristic reaction pattern to the respective drug, and exclusion of other causes of the ILD. Clinically, drug-induced ILD (DI-ILD) may occur as acute ILD with respiratory failure, or as subacute/chronic DI-ILD. Radiation injury to the lung can develop during or following radiation therapy and depends on the nature and dose of the ionizing radiation, as well as the direction of the radiation beam."},"zh":{"name":"药物或辐射相关间质性肺病"},"tr":{"name":"İlaç veya radyasyona maruz kalma nedeniyle interstisyel akciğer hastalığı"}},"xrefs":[{"source":"ICD-10","code":"J70.2","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"J70.3","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"J70.4","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"CB0Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017039","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5680746","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":264984,"name":"Exposure-related interstitial lung disease","classifications":[184,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}