{"orpha":254509,"name":"Iatrogenic botulism","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Inadvertent botulism"],"definition":"Iatrogenic botulism is the most recent man-made form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and it may occur as an adverse event after therapeutic or cosmetic use.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-254509/","orphanet_url":"https://www.orpha.net/en/disease/detail/254509","names":{"fr":{"name":"Botulisme iatrogène","definition":"Le botulisme iatrogène est la forme provoquée par l'homme la plus récente de botulisme , une rare maladie acquise de la jonction neuromusculaire avec paralysie flasque descendante due à la neurotoxine botulique (BoNT) et il s'agit d'un effet indésirable après l'utilisation de la toxine à visée thérapeutique ou cosmétique."},"de":{"name":"Botulismus, iatrogener","definition":"Der iatrogene Botulismus ist in der letzten Zeit die häufigste Art von menschgemachtem Botulismus, einer seltenen erworbenen Störung der Muskelendplatte mit durch Botulinum-Neurotoxine (BoNTs) verursachter absteigender schlaffer Parese. Er tritt akzidentell auf oder nach therapeutischer oder kosmetischer Anwendung."},"es":{"name":"Botulismo iatrogénico","definition":"El botulismo iatrogénico es la forma de botulismo más reciente, una enfermedad adquirida poco frecuente de la unión neuromuscular con parálisis flácida descendente causada por las neurotoxinas botulínicas (&#8211;BoNT-), y puede ocurrir como un evento adverso después del uso terapéutico o cosmético."},"it":{"name":"Botulismo iatrogeno","synonyms":["Botulismo involontario"],"definition":"Il botulismo iatrogeno è una forma di botulismo (si veda questo termine) provocata dall'uomo, descritta di recente. È una malattia rara acquisita delle giunzioni neuromuscolari associata a paralisi flaccida discendente da neurotossina del botulino (BoNT) e può essere secondaria all'uso della tossina per fini terapeutici o cosmetici."},"nl":{"name":"Iatrogeen botulisme","synonyms":["Onbedoeld botulisme"],"definition":"De meest recente kunstmatige vorm van botulisme, een zeldzame verworven aandoening van neuromusculaire overgang met afdalende slappe paralyse veroorzaakt door botuline-neurotoxinen (BoNT's), die kan optreden als bijwerking na therapeutisch of cosmetisch gebruik."},"pt":{"name":"Botulismo iatrogénico","synonyms":["Botulismo acidental"],"definition":"O botulismo iatrogénico é a forma mais recente de botulismo de origem humana (ver este termo), uma doença rara adquirida da junção neuromuscular com paralisia flácida descendente causada por neurotoxinas botulínicas (BoNTs), e pode ocorrer como um evento adverso após o uso terapêutico ou cosmético."},"pl":{"name":"Botulizm jatrogenny","synonyms":["Inadvertent botulism"]},"cs":{"name":"Iatrogenní botulismus","synonyms":["Bezděčný botulismus"]},"uk":{"name":"Ятрогенний ботулізм","synonyms":["Ненавмисний ботулізм"],"definition":"Iatrogenic botulism is the most recent man-made form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and it may occur as an adverse event after therapeutic or cosmetic use."},"zh":{"name":"医源性肉毒中毒","synonyms":["意外性肉毒中度"],"definition":"医源性肉毒中毒是肉毒杆菌中毒的一种新发的人为形式，是一种罕见的获得性神经肌肉接头疾病，表现出由肉毒杆菌神经毒素(BoNTs)引起的下行迟缓性瘫痪，可能是治疗或美容后发生的不良事件。"},"tr":{"name":"İyatrojenik botulizm","synonyms":["Kasti olmayan botulizm"]}},"xrefs":[{"source":"ICD-10","code":"A05.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1A11.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"230654666"},{"source":"MONDO","code":"0016778","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4288922","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":1267,"name":"Botulism","classifications":[181,189,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":180.0,"area":"Worldwide","status":"Validated","source":"[EXPERT]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006597","label":"Diaphragmatic paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001278","label":"Orthostatic hypotension","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000508","label":"Ptosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000217","label":"Xerostomia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000016","label":"Urinary retention","frequency":"Frequent (79-30%)","criteria":null}]}}