{"orpha":254504,"name":"Inhalational botulism","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Inhalation botulism"],"definition":"Inhalational botulism is a man-made form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-254504/","orphanet_url":"https://www.orpha.net/en/disease/detail/254504","names":{"fr":{"name":"Botulisme par inhalation","definition":"Le botulisme par inhalation est une forme provoquée par l'homme de botulisme , une maladie acquise rare de la jonction neuromusculaire avec paralysie flasque descendante due à la neurotoxine botulique (BoNT)."},"de":{"name":"Botulismus, inhalativer","definition":"Der Inhalationsbotulismus ist eine akzidentell hervorgerufene Form des Botulismus, einer seltenen erworbenen Störung der Muskelendplatte mit, durch Botulinum-Neurotoxine (BoNTs) verursachter, absteigender schlaffer Parese."},"es":{"name":"Botulismo por inhalación","definition":"El botulismo por inhalación es una forma de botulismo (una enfermedad rara adquirida de la unión neuromuscular con parálisis flácida descendente causada por la neurotoxina botulínica &#8211;BoNT-) provocada por el hombre."},"it":{"name":"Botulismo da inalazione","definition":"Il botulismo da inalazione è una forma di botulismo (si veda questo termine) provocata dall'uomo. È una malattia rara acquisita delle giunzioni neuromuscolari associata a paralisi flaccida discendente da neurotossina del botulino (BoNT)."},"nl":{"name":"Inhalatiebotulisme","definition":"Een kunstmatige vorm van botulisme, een zeldzame verworven aandoening van neuromusculaire overgang met afdalende slappe paralyse veroorzaakt door botuline-neurotoxinen (BoNT's)."},"pt":{"name":"Botulismo inalatório","synonyms":["Botulismo por inalação"],"definition":"O botulismo por inalação é uma forma de botulismo (ver este termo) provocada pelo homem, uma doença rara adquirida da junção neuromuscular com paralisia flácida descendente causada por neurotoxinas botulínicas (BoNTs)."},"pl":{"name":"Botulizm inhalacyjny","synonyms":["Inhalation botulism"]},"cs":{"name":"Inhalační botulismus","synonyms":["Inhalation botulism"]},"uk":{"name":"Інгаляційний ботулізм","synonyms":["Інгаляційний ботулізм"],"definition":"Inhalational botulism is a man-made form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs)."},"zh":{"name":"吸入性肉毒中毒","synonyms":["吸入性肉毒中毒"],"definition":"吸入性肉毒中毒是肉毒中毒（见该词条）的一种人为形式，是一种罕见的获得性神经肌肉接头疾病，表现出由肉毒神经毒素(BoNTs)引起的下行弛缓性瘫痪。"},"tr":{"name":"İnhalasyon botulizmi","synonyms":["İnhalasyon botulizmi"]}},"xrefs":[{"source":"ICD-10","code":"A05.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1A11.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1881625139"},{"source":"MONDO","code":"0016777","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1443900","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":1267,"name":"Botulism","classifications":[181,189,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":10.0,"area":"Worldwide","status":"Validated","source":"[EXPERT]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002019","label":"Constipation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000508","label":"Ptosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000016","label":"Urinary retention","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000217","label":"Xerostomia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null}]}}