{"orpha":251656,"name":"Oligoastrocytoma, dual genotype","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["MOA","Mixed oligoastrocytoma","Oligoastrocytoma, dual genotype NEC","Oligoastrocytoma, dual genotype, not elsewhere classified"],"definition":"Oligoastrocytoma is a type of low-grade glioma with a mixed astrocytoma and oligodendroglioma histology, manifesting with headaches, speech and motor problems, seizures and, in some, subarachnoid haemorrhage.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-251656/","orphanet_url":"https://www.orpha.net/en/disease/detail/251656","names":{"fr":{"name":"Oligoastrocytome, génotype hybride","synonyms":["MOA","Oligoastrocytome mixte","Oligoastrocytome, génotype hybride NEC","Oligoastrocytome, génotype hybride not elsewhere classified"],"definition":"L'oligoastrocytome est un type de gliome de bas grade avec une histologie mixte d'astrocytome et d'ologodendrogliome. Il se manifeste par des céphalées, des troubles moteurs et du langage, des convulsions, et dans certains cas, des hémorragies sous-arachnoïdiennes."},"de":{"name":"Oligoastrozytom mit dualem Genotyp","synonyms":["MOA","Oligoastrozytom, gemischtes","Oligoastrozytom mit doppeltem Genotyp, andernorts nicht klassifiziert"]},"es":{"name":"Oligoastrocitoma de genotipo dual","synonyms":["MOA","Oligoastrocitoma mixto","Oligoastrocitoma, genotipo dual, no clasificado en otra parte"],"definition":"El oligoastrocitoma es un tipo de glioma de bajo grado con histología mixta de astrocitoma y oligodendroglioma. Se manifiesta con dolores de cabeza, problemas del habla y motores, convulsiones y, en algunos casos, hemorragia subaracnoidea."},"it":{"name":"Oligoastrocitoma, genotipo ibrido","synonyms":["MOA","Oligoastrocitoma misto","Oligoastrocitoma, genotipo ibrido NEC","Oligoastrocitoma, genotipo ibrido, non classificato diversamente"],"definition":"L'oligoastrocitoma è una forma di glioma a bassa malignità associata ad un'istologia mista di astrocitoma e oligodendroglioma; è caratterizzato da cefalee, disturbi del linguaggio e del movimento, crisi epilettiche e, in alcuni casi, emorragia subaracnoidea."},"nl":{"name":"Oligoastrocytoom, duaal genotype","synonyms":["Gemengd oligoastrocytoom","MOA","Oligoastrocytoom, duaal genotype NEC","Oligoastrocytoom, duaal genotype, niet elders geclassificeerd"],"definition":"Oligoastrocytoom is een type laaggradig glioom met een gemengde astrocytoom- en oligodendroglioom-histologie dat zich manifesteert met hoofdpijn, spraak- en bewegingsproblemen, insulten en, in sommige gevallen, subarachnoïdale bloeding."},"pt":{"name":"Oligoastrocitoma","synonyms":["MOA","Oligoastrocitoma misto"]},"pl":{"name":"Skąpodrzewiakogwiaździak","synonyms":["MOA","Skąpodrzewiakogwiaździak mieszany"]},"cs":{"name":"Oligoastrocytom","synonyms":["MOA","Smíšený oligoastrocytom"]},"uk":{"name":"Олігоастроцитома","synonyms":["Змішана олігоастроцитома","MOA"],"definition":"Oligoastrocytoma is a type of low-grade glioma with a mixed astrocytoma and oligodendroglioma histology, manifesting with headaches, speech and motor problems, seizures and, in some, subarachnoid haemorrhage."},"zh":{"name":"少突星形细胞瘤","synonyms":["少突星形细胞混合瘤"],"definition":"少突胶质-星形细胞瘤是一种低级别胶质瘤，具有星形细胞瘤和少突胶质细胞瘤的混合组织学特征，表现为头痛、言语和运动障碍、癫痫发作，在某些情况下还会出现蛛网膜下腔出血。"},"tr":{"name":"Oligoastrositom","synonyms":["MOA","Karma oligoastrositom"]}},"xrefs":[{"source":"ICD-10","code":"C71.9","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"2A00.0Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"603362724"},{"source":"MONDO","code":"0016702","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0547065","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9769","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10073131","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":251651,"name":"Oligoastrocytic tumor","classifications":[181,202]}],"children":[],"genes":[{"symbol":"IDH2","name":"isocitrate dehydrogenase (NADP(+)) 2","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"19228619[PMID]_19554337[PMID]_23109653[PMID]_24149775[PMID]_20714900[PMID]_21075857[PMID]","hgnc":"5383","ensembl":"ENSG00000182054","omim":"147650","loci":["15q26.1"]}],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}