{"orpha":251598,"name":"Protoplasmic astrocytoma","type":"Histopathological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-251598/","orphanet_url":"https://www.orpha.net/en/disease/detail/251598","names":{"fr":{"name":"Astrocytome protoplasmique"},"de":{"name":"Astrozytom, protoplasmisches"},"es":{"name":"Astrocitoma protoplásmico"},"it":{"name":"Astrocitoma protoplasmatico"},"nl":{"name":"Protoplasmisch astrocytoom"},"pt":{"name":"Astrocitoma protoplásmico"},"pl":{"name":"Gwiaździak protoplazmatyczny"},"cs":{"name":"Protoplazmatický astrocytom"},"uk":{"name":"Протоплазматична астроцитома"},"zh":{"name":"原浆型星形细胞瘤"},"tr":{"name":"Protoplazmik astrositom"}},"xrefs":[{"source":"ICD-10","code":"C71.9","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"2A00.0Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"412260377"},{"source":"ICD-11","code":"XH6UV4","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1052848374"},{"source":"MONDO","code":"0016687","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0334580","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":251595,"name":"Astrocytoma grade 2","classifications":[181,202]}],"children":[],"genes":[{"symbol":"IDH2","name":"isocitrate dehydrogenase (NADP(+)) 2","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"19228619[PMID]_19554337[PMID]_23109653[PMID]_24149775[PMID]_20714900[PMID]_21075857[PMID]","hgnc":"5383","ensembl":"ENSG00000182054","omim":"147650","loci":["15q26.1"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Childhood"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}