{"orpha":251576,"name":"Gliosarcoma","type":"Histopathological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":"This disease is described under Glioblastoma","url":"https://raremap.alftech.space/d/ORPHA-251576/","orphanet_url":"https://www.orpha.net/en/disease/detail/251576","names":{"fr":{"name":"Gliosarcome"},"de":{"name":"Gliosarkom"},"es":{"name":"Gliosarcoma"},"it":{"name":"Gliosarcoma"},"nl":{"name":"Gliosarcoom"},"pt":{"name":"Gliossarcoma"},"pl":{"name":"Glejakomięsak"},"cs":{"name":"Gliosarkom"},"uk":{"name":"Гліосаркома"},"zh":{"name":"神经胶质肉瘤"},"tr":{"name":"Gliosarkom"}},"xrefs":[{"source":"ICD-10","code":"C71.9","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"2A00.00","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"358853104"},{"source":"ICD-11","code":"XH9RC8","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"38838668"},{"source":"MONDO","code":"0016681","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D018316","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0206726","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5653","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10018340","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":360,"name":"Glioblastoma","classifications":[181,202]}],"children":[],"genes":[{"symbol":"IDH1","name":"isocitrate dehydrogenase (NADP(+)) 1","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"18772396[PMID]","hgnc":"5382","ensembl":"ENSG00000138413","omim":"147700","loci":["2q34"]},{"symbol":"MGMT","name":"O-6-methylguanine-DNA methyltransferase","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"22380407[PMID]_20556478[PMID]","hgnc":"7059","ensembl":"ENSG00000170430","omim":"156569","loci":["10q26.3"]},{"symbol":"NFKBIA","name":"NFKB inhibitor alpha","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"25215581[PMID]","hgnc":"7797","ensembl":"ENSG00000100906","omim":"164008","loci":["14q13.2"]},{"symbol":"PPARG","name":"peroxisome proliferator activated receptor gamma","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"10851250[PMID]","hgnc":"9236","ensembl":"ENSG00000132170","omim":"601487","loci":["3p25.2"]},{"symbol":"TP53","name":"tumor protein p53","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Assessed","source":"17785346[PMID]","hgnc":"11998","ensembl":"ENSG00000141510","omim":"191170","loci":["17p13.1"]},{"symbol":"LZTR1","name":"leucine zipper like post translational regulator 1","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"24071842[PMID]_23917401[PMID]","hgnc":"6742","ensembl":"ENSG00000099949","omim":"600574","loci":["22q11.21"]},{"symbol":"EGFR","name":"epidermal growth factor receptor","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"24075187[PMID]_24071942[PMID]","hgnc":"3236","ensembl":"ENSG00000146648","omim":"131550","loci":["7p11.2"]},{"symbol":"FGFR1","name":"fibroblast growth factor receptor 1","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"22837387[PMID]","hgnc":"3688","ensembl":"ENSG00000077782","omim":"136350","loci":["8p11.23"]},{"symbol":"FGFR3","name":"fibroblast growth factor receptor 3","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"22837387[PMID]","hgnc":"3690","ensembl":"ENSG00000068078","omim":"134934","loci":["4p16.3"]},{"symbol":"SEPTIN14","name":"septin 14","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"24075187[PMID]_24071942[PMID]","hgnc":"33280","ensembl":"ENSG00000154997","omim":"612140","loci":["7p11.2"]},{"symbol":"TACC1","name":"transforming acidic coiled-coil containing protein 1","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"22837387[PMID]","hgnc":"11522","ensembl":"ENSG00000147526","omim":"605301","loci":["8p11.22"]},{"symbol":"TACC3","name":"transforming acidic coiled-coil containing protein 3","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"22837387[PMID]","hgnc":"11524","ensembl":"ENSG00000013810","omim":"605303","loci":["4p16.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.03,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}