{"orpha":251332,"name":"Unexplained long-lasting fever/inflammatory syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Persistent fever/inflammation of unknown origin"],"definition":"A rare systemic disease characterized by febrile illness (body temperature >38.3°C on several occasions) or inflammation (elevated serum C-reactive protein and erythrocyte sedimentation rate) lasting at least three weeks and for which no specific diagnosis is achieved despite extended diagnostics.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-251332/","orphanet_url":"https://www.orpha.net/en/disease/detail/251332","names":{"fr":{"name":"Syndrome inflammatoire/fièvre de longue durée inexpliquée","synonyms":["Fièvre/inflammation prolongée d'origine indéterminée"],"definition":"Maladie systémique rare caractérisée par un état fébrile (température corporelle >38,3°C mesurée à plusieurs reprises) ou une inflammation (un taux élevé de protéine C-réactive sérique et une vitesse de sédimentation des érythrocytes élevée) qui dure au moins trois semaines et pour laquelle aucun diagnostic spécifique n'est obtenu malgré des examens approfondis."},"de":{"name":"Fieber-Syndrom, langanhaltendes unerklärbares","synonyms":["Persistierendes Fieber/Anhaltende Inflammation unbekannter Ursache"],"definition":"Eine seltene Systemerkrankung, die durch eine mindestens drei Wochen anhaltende fieberhafte Erkrankung (Körpertemperatur > 38,3 °C bei mehreren Episoden) oder Entzündung (Erhöhung des C-reaktiven Proteins und der Erythrozytensedimentationsrate im Serum) gekennzeichnet ist und bei der trotz erweiterter Diagnostik keine spezifische Diagnose gestellt werden kann."},"es":{"name":"Fiebre inexplicada de larga duración/síndrome inflamatorio","synonyms":["Fiebre persistente/inflamación de origen desconocido"],"definition":"Es una enfermedad sistémica poco frecuente caracterizada por una enfermedad febril (temperatura corporal> 38,3 ° C en varias ocasiones) o una inflamación (proteína C reactiva sérica y velocidad de sedimentación globular elevadas) que dura al menos tres semanas y para la cual no se consigue un diagnóstico específico a pesar de los diagnósticos extendidos."},"it":{"name":"Sindrome infiammatoria/febbre di lunga durata ad eziologia non nota","definition":"Si tratta di una malattia sistemica rara caratterizzata da malattia febbrile (temperatura corporea >38,3°C in più occasioni) o stato infiammatorio (proteina C-reattiva elevata nel siero e velocità di eritrosedimentazione elevata) di durata pari o superiore alle tre settimane, per le quali non è stata raggiunta una diagnosi malgrado le indagini approfondite."},"nl":{"name":"Onverklaarbare langdurige koorts/inflammatoir syndroom","synonyms":["Persisterende koorts/inflammatie van ongekende oorsprong"],"definition":"Een zeldzame systemische aandoening, gekarakteriseerd door febriele ziekte (lichaamstemperatuur hoger dan 38,3 graden Celsius op meerdere momenten) of inflammatie (verhoogd gehalte van C-reactief proteïne in serum en verhoogde erytrocytbezinkingssnelheid) gedurende minstens drie weken, waarvoor geen specifieke diagnose kan gesteld worden ondanks uitgebreide diagnostiek."},"pt":{"name":"Síndrome inflamatório/febre de longa duração, não explicado"},"pl":{"name":"Niewyjaśniona długotrwała gorączka/zespół zapalny","synonyms":["Persistent fever/inflammation of unknown origin"]},"cs":{"name":"Syndrom nevysvětlitelné dlouhotrvající horečky či zánětu","synonyms":["Persistent fever/inflammation of unknown origin"]},"uk":{"name":"Незрозуміла тривала лихоманка/запальний синдром","synonyms":["Стійка лихоманка/запалення невідомого походження"],"definition":"A rare systemic disease characterized by febrile illness (body temperature >38.3°C on several occasions) or inflammation (elevated serum C-reactive protein and erythrocyte sedimentation rate) lasting at least three weeks and for which no specific diagnosis is achieved despite extended diagnostics."},"zh":{"name":"原因不明的长期发热/炎症综合征","synonyms":["原因不明的持续发热/炎症综合征"]},"tr":{"name":"Açıklanamayan uzun süreli ateş / inflamatuar sendrom","synonyms":["Kalıcı ateş / kaynağı bilinmeyen inflamasyon"]}},"xrefs":[{"source":"ICD-10","code":"R50.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"MG26","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0016666","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5679630","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":280373,"name":"Rare pediatric systemic disease","classifications":[231]},{"orpha":182222,"name":"Rare systemic disease","classifications":[196]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[],"phenotypes":null}