{"orpha":251325,"name":"Drug-induced vasculitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare secondary vasculitis characterized by inflammation of blood vessels caused by various drugs, including antibiotics, anti-tumor necrosis factor-alpha agents, immunotherapeutic drugs, and psychoactive agents, among others. The skin is most commonly affected, but other tissues and organs, such as the subcutis, kidneys, or lungs, may also be involved. Systemic disease develops only in a minority of patients, typically when treated with the causative drug over a prolonged period of time. Presenting signs and symptoms include skin rash, myalgia, arthralgia, fever, and malaise.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-251325/","orphanet_url":"https://www.orpha.net/en/disease/detail/251325","names":{"fr":{"name":"Vascularite induite par les médicaments","definition":"Vascularite secondaire rare caractérisée par une inflammation des vaisseaux sanguins provoquée par différents médicaments, dont certains antibiotiques, des agents anti-facteur de nécrose tumorale-alpha, des médicaments immunothérapeutiques et des agents psychoactifs, entre autres. La peau est l'organe le plus souvent touché, mais d'autres tissus, tels que le tissu sous-cutané, et organes, tels que les reins ou les poumons, peuvent également être concernés. Seule une minorité de patients traités par le médicament incriminé sur une période prolongée développent une forme systémique. Parmi les signes et symptômes initiaux figurent : éruption cutanée, myalgie, arthralgie, fièvre et malaise."},"de":{"name":"Vaskulitis, Medikamenten-induzierte","definition":"Eine seltene sekundäre Vaskulitis, die durch eine Entzündung der Blutgefäße gekennzeichnet ist und durch verschiedene Medikamente verursacht wird, darunter Antibiotika, Anti-Tumor-Nekrose-Faktor-Alpha-Mittel, Immuntherapeutika und psychoaktive Mittel. Am häufigsten ist die Haut betroffen, aber auch andere Gewebe und Organe wie die Unterhaut, die Nieren oder die Lunge können betroffen sein. Eine systemische Erkrankung entwickelt sich nur bei einer Minderheit der Patienten, typischerweise bei einer Behandlung mit dem verursachenden Medikament über einen längeren Zeitraum. Zu den Anzeichen und Symptomen gehören Hautausschlag, Myalgie, Arthralgie, Fieber und Unwohlsein."},"es":{"name":"Vasculitis inducida por fármacos","synonyms":["Vasculitis inducida por medicamentos"],"definition":"Es una vasculitis secundaria poco frecuente caracterizada por una inflamación de los vasos sanguíneos causada por varios fármacos, incluyendo antibióticos, agentes antagonistas del factor de necrosis tumoral alfa, fármacos inmunoterapéuticos y agentes psicoactivos, entre otros. La piel es el órgano más comúnmente afectado, pero también pueden estar involucrados otros tejidos y órganos, como el tejido subcutáneo, los riñones o los pulmones. La enfermedad sistémica se desarrolla sólo en una minoría de pacientes, generalmente cuando se administra el fármaco causante durante un período prolongado de tiempo. Los signos y síntomas que se presentan incluyen erupción cutánea, mialgia, artralgia, fiebre y malestar general."},"it":{"name":"Vasculite indotta da farmaci","definition":"Si tratta di una vasculite secondaria rara, caratterizzata dall'infiammazione dei vasi sanguigni causata da diversi agenti farmacologici, tra i quali alcuni antibiotici, alcuni agenti inibitori del fattore di necrosi tumorale-alfa e alcune sostanze psicoattive. Di solito la cute è maggiormente interessata, ma possono essere coinvolti anche altri tessuti e organi, come la regione sottocutanea, i reni e i polmoni. Un numero limitato di pazienti sviluppa una malattia sistemica, a seguito di un trattamento prolungato con il farmaco scatenante. I sintomi d'esordio caratteristici comprendono l'eruzione cutanea, la mialgia, l'artralgia, la febbre e il malessere."},"nl":{"name":"Medicatiegeïnduceerde vasculitis","definition":"Een zeldzame secundaire vasculitis, gekenmerkt door inflammatie van bloedvaten veroorzaakt door verschillende geneesmiddelen, waaronder antibiotica, anti-tumornecrosefactor-alfa agentia, immunotherapeutische geneesmiddelen, en psychoactieve substanties. Doorgaans is de huid aangetast, maar andere weefsels en organen, zoals subcutis, nier of long kunnen ook betrokken zijn. Systemische ziekte ontwikkelt slechts bij een minderheid van de patiënten, doorgaans wanneer die gedurende een lange periode werden behandeld met het causale geneesmiddel. Presenterende verschijnselen en symptomen zijn onder meer huiduitslag, myalgie, artralgie, koorts, en malaise."},"pt":{"name":"Vasculite induzida por fármacos","definition":"Vasculite secundária rara caracterizada por inflamação dos vasos sanguíneos causada por vários medicamentos, incluindo antibióticos, agentes anti-fator de necrose tumoral alfa, fármacos imunoterapêuticos e agentes psicoativos, entre outros. A pele é mais comummente afetada, mas outros tecidos e órgãos, como tecido subcutâneo, rins ou pulmões, também podem estar envolvidos. A doença sistémica desenvolve-se apenas numa minoria de doentes, normalmente quando tratada com o medicamento causador durante um período de tempo prolongado. Os sinais e sintomas de apresentação incluem erupção cutânea, mialgia, artralgia, febre e mal-estar."},"pl":{"name":"Zapalenie naczyń indukowane lekami"},"cs":{"name":"Léky indukovaná vaskulitida"},"uk":{"name":"Медикаментозний васкуліт","definition":"A rare secondary vasculitis characterized by inflammation of blood vessels caused by various drugs, including antibiotics, anti-tumor necrosis factor-alpha agents, immunotherapeutic drugs, and psychoactive agents, among others. The skin is most commonly affected, but other tissues and organs, such as the subcutis, kidneys, or lungs, may also be involved. Systemic disease develops only in a minority of patients, typically when treated with the causative drug over a prolonged period of time. Presenting signs and symptoms include skin rash, myalgia, arthralgia, fever, and malaise."},"zh":{"name":"药物性血管炎"},"tr":{"name":"İlaca bağlı vaskülit"}},"xrefs":[{"source":"ICD-10","code":"M31.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"4A85.03","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1376183765"},{"source":"MONDO","code":"0016664","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0340672","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":445197,"name":"Secondary vasculitis","classifications":[196,198,231]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}